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Pieter-Jan Martens Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Conny Gysemans Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Chantal Mathieu Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Introduction The year 2021 will celebrate the 100 th anniversary of the clinical use of insulin. This embodied a lifesaver for people living with type 1 diabetes (T1D), the most common chronic disease in children and young adolescents. But it

Article Type:
Review Article
Collections:
100 years of insulin: A special collection
DOI:
https://doi.org/10.1530/JOE-20-0552
Volume/Issue:
Volume 249: Issue 2
Free access
Claire E Hills Department of Biological Sciences, Department of Infection, Biomedical Research Institute, The University of Warwick, Coventry CV4 7AL, UK

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Paul E Squires
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Rosemary Bland
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diabetes. However, small alterations in Na + absorption by renal cells may be responsible for some of the changes seen in cellular function in diabetic nephropathy. One of the key regulators of Na + reabsorption in the nephron is the serum and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0295
Volume/Issue:
Volume 199: Issue 3
Free access
Qidi Wang Diabetes Research Center, Endocrine and Metabolic Division, Brussels Free University-VUB and JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, Belgium

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Ying Cai Diabetes Research Center, Endocrine and Metabolic Division, Brussels Free University-VUB and JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, Belgium

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Mark Van de Casteele Diabetes Research Center, Endocrine and Metabolic Division, Brussels Free University-VUB and JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, Belgium

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Daniel Pipeleers Diabetes Research Center, Endocrine and Metabolic Division, Brussels Free University-VUB and JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, Belgium

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Zhidong Ling Diabetes Research Center, Endocrine and Metabolic Division, Brussels Free University-VUB and JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, Belgium
Diabetes Research Center, Endocrine and Metabolic Division, Brussels Free University-VUB and JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, Belgium

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Introduction Sulfonylurea has been used in the treatment of diabetes for decades. Its hypoglycemic action is attributed to stimulation of insulin release that rapidly follows the drug's binding to the SUR receptor of β cells and the subsequent rise

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0372
Volume/Issue:
Volume 208: Issue 2
Free access
Smithamol Sithara Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Australia

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Tamsyn M Crowley School of Medicine, MMR, Bioinformatics Core Research Facility, Deakin University, Geelong, Australia

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Ken Walder Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Australia

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Kathryn Aston-Mourney Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Australia

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Introduction Type 2 diabetes (T2D) is an increasing problem currently affecting the health and lifestyle of more than 422 million people worldwide ( NCD-RisC 2016 ), NCD-RisC a number that is expected to rise to 592 million by 2035

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0515
Volume/Issue:
Volume 232: Issue 2
Free access
Jacob Jelsing
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Niels Vrang
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Søren B van Witteloostuijn
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Michael Mark Gubra ApS, Boehringer Ingelheim Pharma GmbH & Co. KG, Agern Alle 1, 2970 Hørsholm, Denmark

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Thomas Klein Gubra ApS, Boehringer Ingelheim Pharma GmbH & Co. KG, Agern Alle 1, 2970 Hørsholm, Denmark

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inhibition of glucagon secretion and gastric emptying ( Holst 2007 ). Long-term treatment with GLP1 receptor agonists reduces food intake and promotes weight loss in both preclinical experiments and clinical studies on patients with or without type 2 diabetes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0479
Volume/Issue:
Volume 214: Issue 3
Free access
Jennifer A Crookshank Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Daniel Serrano Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Gen-Sheng Wang Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Christopher Patrick Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

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Baylie S Morgan Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biomedical Sciences, University of Ottawa, Ottawa, Ontario, Canada

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Marie-France Paré Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Fraser W Scott Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada

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Introduction Type 1 diabetes (T1D) occurs in a small subset of genetically susceptible individuals whose immune systems destroy most of the pancreatic β-cells. Recent studies suggest that T1D begins in humans at a very early age, but the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0328
Volume/Issue:
Volume 239: Issue 2
Free access
T C Alba-Loureiro Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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S M Hirabara Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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J R Mendonça Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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R Curi Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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T C Pithon-Curi Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo SP, Brazil
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil

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Introduction Patients with diabetes mellitus have increased susceptibility to and severity of infections. Several studies have shown alterations in neutrophil function, an effect that contributes to the high incidence of infections

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06438
Volume/Issue:
Volume 188: Issue 2
Free access
Paz Vital Biophysics Department, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City, 04510, DF, Mexico AP 70-253, Mexico

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Elena Larrieta Biophysics Department, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City, 04510, DF, Mexico AP 70-253, Mexico

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Marcia Hiriart Biophysics Department, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City, 04510, DF, Mexico AP 70-253, Mexico

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Introduction Diabetes mellitus is a common metabolic disease. Type 2 diabetes is rapidly becoming pandemic, and although the origin of this disease is not entirely clear, it is accepted that insulin resistance is important in its

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06596
Volume/Issue:
Volume 190: Issue 2
Free access
Elisabete A Forsberg The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Ileana R Botusan The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Jing Wang The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Verena Peters The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Ishrath Ansurudeen The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Kerstin Brismar The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Sergiu Bogdan Catrina The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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suppressor protein that acts as an E3 ubiquitin ligase and targets HIF-1α for proteasome degradation ( Kaelin & Ratcliffe 2008 ). Increased liver IGFBP1 synthesis is observed in states of insulin resistance, such as diabetes type 2 ( Munoz et al . 1996

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0571
Volume/Issue:
Volume 225: Issue 3
Free access
Richard R Almon Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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Debra C DuBois Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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William Lai Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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Bai Xue Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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Jing Nie Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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William J Jusko Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of

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Introduction Although rare forms of human type 2 diabetes are associated with defects in individual genes, more common forms appear to involve a complex interaction between predisposing genetic backgrounds and environmental factors. While epigenetic

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0404
Volume/Issue:
Volume 200: Issue 3
Free access