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Introduction The year 2021 will celebrate the 100 th anniversary of the clinical use of insulin. This embodied a lifesaver for people living with type 1 diabetes (T1D), the most common chronic disease in children and young adolescents. But it
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diabetes. However, small alterations in Na + absorption by renal cells may be responsible for some of the changes seen in cellular function in diabetic nephropathy. One of the key regulators of Na + reabsorption in the nephron is the serum and
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Diabetes Research Center, Endocrine and Metabolic Division, Brussels Free University-VUB and JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, B-1090 Brussels, Belgium
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Introduction Sulfonylurea has been used in the treatment of diabetes for decades. Its hypoglycemic action is attributed to stimulation of insulin release that rapidly follows the drug's binding to the SUR receptor of β cells and the subsequent rise
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Introduction Type 2 diabetes (T2D) is an increasing problem currently affecting the health and lifestyle of more than 422 million people worldwide ( NCD-RisC 2016 ), NCD-RisC a number that is expected to rise to 592 million by 2035
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inhibition of glucagon secretion and gastric emptying ( Holst 2007 ). Long-term treatment with GLP1 receptor agonists reduces food intake and promotes weight loss in both preclinical experiments and clinical studies on patients with or without type 2 diabetes
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Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
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Department of Biomedical Sciences, University of Ottawa, Ottawa, Ontario, Canada
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Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada
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Introduction Type 1 diabetes (T1D) occurs in a small subset of genetically susceptible individuals whose immune systems destroy most of the pancreatic β-cells. Recent studies suggest that T1D begins in humans at a very early age, but the
Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil
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Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil
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Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil
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Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil
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Institute of Health Sciences, University of São Judas Tadeu, Taquari, 546-Mooca, 03166-000 São Paulo SP, Brazil
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Introduction Patients with diabetes mellitus have increased susceptibility to and severity of infections. Several studies have shown alterations in neutrophil function, an effect that contributes to the high incidence of infections
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Introduction Diabetes mellitus is a common metabolic disease. Type 2 diabetes is rapidly becoming pandemic, and although the origin of this disease is not entirely clear, it is accepted that insulin resistance is important in its
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The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
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The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
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suppressor protein that acts as an E3 ubiquitin ligase and targets HIF-1α for proteasome degradation ( Kaelin & Ratcliffe 2008 ). Increased liver IGFBP1 synthesis is observed in states of insulin resistance, such as diabetes type 2 ( Munoz et al . 1996
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
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Pharmaceutical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, Departments of
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Introduction Although rare forms of human type 2 diabetes are associated with defects in individual genes, more common forms appear to involve a complex interaction between predisposing genetic backgrounds and environmental factors. While epigenetic