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Ryan A Lafferty Biomedical Sciences Research Institute, Centre for Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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Laura M McShane Biomedical Sciences Research Institute, Centre for Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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Zara J Franklin Biomedical Sciences Research Institute, Centre for Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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Peter R Flatt Biomedical Sciences Research Institute, Centre for Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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Finbarr P M O’Harte Biomedical Sciences Research Institute, Centre for Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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Nigel Irwin Biomedical Sciences Research Institute, Centre for Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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Introduction It has been well established that abnormal elevation in circulating glucagon leads to an increase in hepatic glucose production and glycogen metabolism that contribute to hyperglycaemia in diabetes ( Unger 1978 ). For this reason

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0106
Volume/Issue:
Volume 255: Issue 2
Open access
James C Needell Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA

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Madalyn N Brown Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA

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Danny Zipris Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA

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Introduction Type 1 diabetes (T1D) is a proinflammatory progressive disease thought to be triggered by both genetic and environmental factors ( Atkinson et al . 2014 ). There is evidence supporting the notion that viruses are key players in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0131
Volume/Issue:
Volume 238: Issue 1
Free access
Karen Oliva Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Gillian Barker Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Gregory E Rice Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Mark J Bailey Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Martha Lappas Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia

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Introduction The prevalence of type 2 diabetes is increasing rapidly. Alarmingly, it is predicted that ∼350 million people worldwide will be diagnosed with type 2 diabetes by the year 2030, double the current number ( Wild et al . 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0010
Volume/Issue:
Volume 218: Issue 2
Free access
Christy M Gliniak Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, United States

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Line Pedersen Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, United States

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Philipp E Scherer Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, United States

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diabetes, cardiovascular disease, stroke, hypertension, and cancer. Obesity is, by definition, an excess of fat mass. However, the pathogenesis of obesity involves processes that are more complex than the simple accumulation of fat. Adipose tissue biology

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0180
Volume/Issue:
Volume 259: Issue 3
Free access
Cid Pitombo Departments of Internal Medicine,
Surgery, State University of Campinas, UNICAMP, 13083-970, Campinas, Brazil
Department of Surgery, Rio de Janeiro Federal University, Rio de Janeiro, Brazil

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Eliana P Araújo Departments of Internal Medicine,
Surgery, State University of Campinas, UNICAMP, 13083-970, Campinas, Brazil
Department of Surgery, Rio de Janeiro Federal University, Rio de Janeiro, Brazil

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Cláudio T De Souza Departments of Internal Medicine,
Surgery, State University of Campinas, UNICAMP, 13083-970, Campinas, Brazil
Department of Surgery, Rio de Janeiro Federal University, Rio de Janeiro, Brazil

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José C Pareja Departments of Internal Medicine,
Surgery, State University of Campinas, UNICAMP, 13083-970, Campinas, Brazil
Department of Surgery, Rio de Janeiro Federal University, Rio de Janeiro, Brazil

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Bruno Geloneze Departments of Internal Medicine,
Surgery, State University of Campinas, UNICAMP, 13083-970, Campinas, Brazil
Department of Surgery, Rio de Janeiro Federal University, Rio de Janeiro, Brazil

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Lício A Velloso Departments of Internal Medicine,
Surgery, State University of Campinas, UNICAMP, 13083-970, Campinas, Brazil
Department of Surgery, Rio de Janeiro Federal University, Rio de Janeiro, Brazil

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Introduction Visceral adiposity is one of the main risk factors for the development of insulin resistance, diabetes mellitus, hypertension, and cardiovascular disease ( Ferrannini et al. 1997 , Fujimoto et al. 1999 ). The

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07069
Volume/Issue:
Volume 191: Issue 3
Free access
Yi Lin Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA

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Zhongjie Sun Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA

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patients with type I diabetes and 5–10% of patients with type II diabetes eventually develop ESRD ( Ruggenenti & Remuzzi 1998 , Lin & Sun 2010 a ). Conventional therapies such as strict glycemic control and antihypertensive treatment do not completely stop

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0340
Volume/Issue:
Volume 209: Issue 2
Free access
Hongying An Divisions of Metabolism and Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Ling He Divisions of Metabolism and Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

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Metformin, a time-proven effective agent for the treatment of patients with type 2 diabetes In the medieval Europe, the Gallega officinalis plant was used as a folk medicine to treat diabetes. In the late 1800s, the plant was found to be rich in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0447
Volume/Issue:
Volume 228: Issue 3
Free access
Julie Takada Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Miriam Helena Fonseca-Alaniz Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Tarcila Beatriz Ferraz de Campos Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Sandra Andreotti Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Amanda Baron Campana Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Maristela Okamoto Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Cristina das Neves Borges-Silva Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Ubiratan Fabres Machado Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Fabio Bessa Lima Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Avenue, 05508-900, Sao Paulo, Brazil

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Introduction Hyperglycemia in diabetes mellitus (DM) is a result of inadequate insulin secretion and reduced systemic responsiveness to insulin ( DeFronzo et al . 1992 ). Obesity, most notably central adiposity, is one of the main features of the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0072
Volume/Issue:
Volume 198: Issue 1
Free access
L van Bloemendaal
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J S ten Kulve
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S E la Fleur Diabetes Centre, Department of Endocrinology and Metabolism, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands

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R G Ijzerman
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M Diamant
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Introduction Obesity and type 2 diabetes mellitus (T2DM), also termed ‘diabesity’, are major public health problems due to their pandemic occurrence ( Whiting et al . 2011 , Flegal et al . 2012 ) and their association with adverse consequences

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0414
Volume/Issue:
Volume 221: Issue 1
Free access
Elisabet Estil.les Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain

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Noèlia Téllez Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain
Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain

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Joan Soler Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain
Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain
Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain

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Eduard Montanya Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain
Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain
Laboratory of Diabetes and Experimental Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Endocrine Unit (13-2), Department of Clinical Sciences, IDIBELL-University of Barcelona, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat, Barcelona, Spain

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Introduction β-Cell mass reduction has a central role in the development of type 1 and type 2 diabetes, and in both conditions the loss of β-cells has been largely attributed to increased β-cell death ( Butler et al . 2003 , Devendra et al . 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0047
Volume/Issue:
Volume 203: Issue 1
Free access