Search Results

You are looking at 141 - 150 of 612 items for :

  • macrophages x
  • Refine by access: Content accessible to me x
Clear All
Harman S Mattu Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK

Search for other papers by Harman S Mattu in
Google Scholar
PubMed
Close
and
Harpal S Randeva Division of Metabolic and Vascular Health, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK

Search for other papers by Harpal S Randeva in
Google Scholar
PubMed
Close

as adipose-derived hormones. Adipose tissue comprises adipocytes (30–50%), preadipocytes and fibroblasts, collagen fibre matrix, blood vessels and immune cells (monocytes/macrophages and lymphocytes). Adipokines are peptides secreted by adipocytes

Free access
Silva Sütt Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Silva Sütt in
Google Scholar
PubMed
Close
,
Emmelie Cansby Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Emmelie Cansby in
Google Scholar
PubMed
Close
,
Alexandra Paul Department of Biology and Biological Engineering, Division of Chemical Biology, Chalmers University of Technology, Gothenburg, Sweden

Search for other papers by Alexandra Paul in
Google Scholar
PubMed
Close
,
Manoj Amrutkar Department of Hepato-Pancreato-Biliary Surgery, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Search for other papers by Manoj Amrutkar in
Google Scholar
PubMed
Close
,
Esther Nuñez-Durán Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Esther Nuñez-Durán in
Google Scholar
PubMed
Close
,
Nagaraj M Kulkarni Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Nagaraj M Kulkarni in
Google Scholar
PubMed
Close
,
Marcus Ståhlman Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Marcus Ståhlman in
Google Scholar
PubMed
Close
,
Jan Borén Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Jan Borén in
Google Scholar
PubMed
Close
,
Jurga Laurencikiene Lipid Laboratory, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

Search for other papers by Jurga Laurencikiene in
Google Scholar
PubMed
Close
,
Brian W Howell Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York, USA

Search for other papers by Brian W Howell in
Google Scholar
PubMed
Close
,
Sven Enerbäck Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by Sven Enerbäck in
Google Scholar
PubMed
Close
, and
Margit Mahlapuu Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Margit Mahlapuu in
Google Scholar
PubMed
Close

droplets in Stk25 transgenic BAT ( Fig. 2C ). Inflammation in adipose tissue, characterized primarily by macrophage infiltration, plays a key role in linking obesity with systemic insulin resistance and whole-body metabolic dysfunction ( Xu et al . 2003

Free access
M K Piya Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK
Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK

Search for other papers by M K Piya in
Google Scholar
PubMed
Close
,
P G McTernan Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK

Search for other papers by P G McTernan in
Google Scholar
PubMed
Close
, and
S Kumar Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK
Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK

Search for other papers by S Kumar in
Google Scholar
PubMed
Close

responding to inflammatory insults. In addition, adipose tissue also contains a large number of macrophages and thus may support the function as a first line of defence against superficial wounds or stimuli. As adipose tissue may lie directly underneath the

Free access
Gisela Helfer School of Chemistry and Biosciences, University of Bradford, Bradford, UK

Search for other papers by Gisela Helfer in
Google Scholar
PubMed
Close
and
Qing-Feng Wu State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

Search for other papers by Qing-Feng Wu in
Google Scholar
PubMed
Close

elastase and cathepsin G into the milieu ( Wittamer et al . 2003 , 2005 ). Subsequently, chemerin functions to enhance the chemotaxis of immature dendritic cells and macrophages, bridging innate and adaptive immunity for the initiation of immune response

Open access
Philip Newsholme School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

Search for other papers by Philip Newsholme in
Google Scholar
PubMed
Close
,
Vinicius Cruzat School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

Search for other papers by Vinicius Cruzat in
Google Scholar
PubMed
Close
,
Frank Arfuso School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

Search for other papers by Frank Arfuso in
Google Scholar
PubMed
Close
, and
Kevin Keane School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

Search for other papers by Kevin Keane in
Google Scholar
PubMed
Close

that IAPP oligomers can activate and induce IL1β production from dendritic cells and macrophages in vitro ( Masters et al . 2010 ). Other researchers have demonstrated that ceramide can promote IL1β production from macrophages in high-fat diets

Free access
Bohan Wang Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

Search for other papers by Bohan Wang in
Google Scholar
PubMed
Close
,
I Stuart Wood Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

Search for other papers by I Stuart Wood in
Google Scholar
PubMed
Close
, and
Paul Trayhurn Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

Search for other papers by Paul Trayhurn in
Google Scholar
PubMed
Close

-adipokine ( Trayhurn et al . 2008 ). Other major adipokines, murine or human, whose expression is stimulated by hypoxia include angiopoietin-like protein 4 (Angptl4), interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), and vascular endothelial growth

Free access
Peter J Simons Department of Cell Biology, Bioceros BV, Yalelaan 46, 3584 CM Utrecht, The Netherlands
Departments of Experimental and Internal Medicine and
Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

Search for other papers by Peter J Simons in
Google Scholar
PubMed
Close
,
Petra S van den Pangaart Department of Cell Biology, Bioceros BV, Yalelaan 46, 3584 CM Utrecht, The Netherlands
Departments of Experimental and Internal Medicine and
Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

Search for other papers by Petra S van den Pangaart in
Google Scholar
PubMed
Close
,
Johannes M F G Aerts Department of Cell Biology, Bioceros BV, Yalelaan 46, 3584 CM Utrecht, The Netherlands
Departments of Experimental and Internal Medicine and
Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

Search for other papers by Johannes M F G Aerts in
Google Scholar
PubMed
Close
, and
Louis Boon Department of Cell Biology, Bioceros BV, Yalelaan 46, 3584 CM Utrecht, The Netherlands
Departments of Experimental and Internal Medicine and
Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

Search for other papers by Louis Boon in
Google Scholar
PubMed
Close

-inflammatory cytokines, produced by either adipocytes or stromavascular cells and macrophages within adipose tissue, contribute to the chronic low-grade inflammatory state found in obesity and related diseases ( Lyon et al. 2003 , Schmidt & Duncan 2003 ), we

Free access
Juriaan R Metz Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

Search for other papers by Juriaan R Metz in
Google Scholar
PubMed
Close
,
Mark O Huising Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

Search for other papers by Mark O Huising in
Google Scholar
PubMed
Close
,
Karin Leon Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

Search for other papers by Karin Leon in
Google Scholar
PubMed
Close
,
B M Lidy Verburg-van Kemenade Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

Search for other papers by B M Lidy Verburg-van Kemenade in
Google Scholar
PubMed
Close
, and
Gert Flik Department Organismal Animal Physiology, Faculty of Science, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands

Search for other papers by Gert Flik in
Google Scholar
PubMed
Close

sequence (IL-1RI.fw1, 5′(-GCA GAA AAG GCA ATG ATA CIT GG-3′; IL-1RI.rv2, 5′-TAG GCC AGA ACC AGA TCA AC-3′). PCR with these primers on a λZAP cDNA library of PMA-activated carp head kidney macrophages yielded a 745 bp product. PCRs were performed using 0

Free access
Tomoaki Hayakawa Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Search for other papers by Tomoaki Hayakawa in
Google Scholar
PubMed
Close
,
Tomomi Minemura Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Search for other papers by Tomomi Minemura in
Google Scholar
PubMed
Close
,
Toshiharu Onodera Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Search for other papers by Toshiharu Onodera in
Google Scholar
PubMed
Close
,
Jihoon Shin Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
Department of Diabetes Care Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Search for other papers by Jihoon Shin in
Google Scholar
PubMed
Close
,
Yosuke Okuno Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Search for other papers by Yosuke Okuno in
Google Scholar
PubMed
Close
,
Atsunori Fukuhara Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
Department of Adipose Management, Osaka University Graduate School of Medicine, Osaka, Japan

Search for other papers by Atsunori Fukuhara in
Google Scholar
PubMed
Close
,
Michio Otsuki Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Search for other papers by Michio Otsuki in
Google Scholar
PubMed
Close
, and
Iichiro Shimomura Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Search for other papers by Iichiro Shimomura in
Google Scholar
PubMed
Close

macrophage infiltration in the fat pads ( Desarzens & Faresse 2016 ). In sharp contrast to adipocyte-specific MR-KO and GR-KO mice, obese myeloid-specific MR-KO mice exhibited improved glucose intolerance, insulin resistance and hepatic steatosis ( Zhang et

Free access
Prabhakara R Nagareddy Department of Nutrition Sciences, University of Alabama, Birmingham, UK

Search for other papers by Prabhakara R Nagareddy in
Google Scholar
PubMed
Close
,
Sunil K Noothi Department of Nutrition Sciences, University of Alabama, Birmingham, UK

Search for other papers by Sunil K Noothi in
Google Scholar
PubMed
Close
,
Michelle C Flynn Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia
Department of Immunology, Monash University, Melbourne, Australia

Search for other papers by Michelle C Flynn in
Google Scholar
PubMed
Close
, and
Andrew J Murphy Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia
Department of Immunology, Monash University, Melbourne, Australia

Search for other papers by Andrew J Murphy in
Google Scholar
PubMed
Close

) Obesity indirectly promotes myelopoiesis by stimulating IL-1β production from ATM in VAT. (C) Hyperglycemia induces an upregulation in S100A8/A9 that travels to BM to stimulate myelopoiesis. ATM, adipose tissue macrophages; BM, bone marrow; HSPC

Free access