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R C M Simmen Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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J M P Pabona Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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M C Velarde Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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C Simmons Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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O Rahal Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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F A Simmen Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA
Department of Physiology and Biophysics, Interdisciplinary Biomedical Sciences Program, Arkansas Children's Nutrition Center, Buck Institute for Age Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72202, USA

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, mostly because of physical competition between them in binding to cognate sequences in target gene promoters. In vivo , the physiologic functions of most KLF members have been validated by use of gene targeting technologies. This has been the subject of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0329
Volume/Issue:
Volume 204: Issue 3
Free access
Mary C Sugden Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew's and the Royal London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK

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Paul W Caton Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew's and the Royal London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK

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Mark J Holness Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew's and the Royal London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK

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corrected by the administration of PPARα activators by actions to promote removal of intracellular lipid through tissue FA oxidation ( Ye et al . 2001 ). Induction of PPARα gene targets requires the interaction of PPARα and PGC-1, often in complex with

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0359
Volume/Issue:
Volume 204: Issue 2
Free access
Jinwon Eo
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Kyuyong Han
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Kenneth M Murphy Department of Biomedical Science and Technology, Department of Pathology and Immunology, Howard Hughes Medical Institute, Laboratory of Reproductive Biology and Infertility, RCTC, IBST, Konkuk University, 1 Hwayang-Dong, Kwangjin-Gu, Seoul 143-701, South Korea
Department of Biomedical Science and Technology, Department of Pathology and Immunology, Howard Hughes Medical Institute, Laboratory of Reproductive Biology and Infertility, RCTC, IBST, Konkuk University, 1 Hwayang-Dong, Kwangjin-Gu, Seoul 143-701, South Korea

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Haengseok Song Department of Biomedical Science and Technology, Department of Pathology and Immunology, Howard Hughes Medical Institute, Laboratory of Reproductive Biology and Infertility, RCTC, IBST, Konkuk University, 1 Hwayang-Dong, Kwangjin-Gu, Seoul 143-701, South Korea

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Hyunjung Jade Lim
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). The role of Etv5 in male reproduction has recently been revealed in the gene-targeted mouse model. Etv5 −/− male mice exhibit a Sertoli cell-only syndrome ( Chen et al . 2005 ). The cause of male infertility in Etv5 −/− mice is a deficit in

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0142
Volume/Issue:
Volume 198: Issue 2
Free access
Claire E Hills Department of Biological Sciences, Department of Infection, Biomedical Research Institute, The University of Warwick, Coventry CV4 7AL, UK

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Paul E Squires
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Rosemary Bland
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renal tubulointerstitial damage in gene-targeted mice lacking SGK1 . Journal of Molecular Medicine 84 737 – 746 . Bell LM Leong ML Kim B Wang E Park J Hemmings BA Firestone GL 2000 Hyperosmotic stress stimulates promoter activity

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0295
Volume/Issue:
Volume 199: Issue 3
Free access
E E Connor Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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D L Wood Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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T S Sonstegard Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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A F da Mota Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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G L Bennett Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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J L Williams Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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A V Capuco Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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557823 (PR)) or tentative consensus sequences in the Bos taurus Gene Index ( http://www.tigr.org/ ; TC180604 (ERRα)). Primer sequences and annealing temperature used for each gene target are presented in Table 1 . Real-time PCR was performed in the Bio

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06139
Volume/Issue:
Volume 185: Issue 3
Free access
Margaret B Allison Departments of Internal Medicine, and Molecular and Integrative Physiology, University of Michigan, 1000 Wall Street, 6317 Brehm Tower, Ann Arbor, Michigan 48105, USA

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Martin G Myers Jr Departments of Internal Medicine, and Molecular and Integrative Physiology, University of Michigan, 1000 Wall Street, 6317 Brehm Tower, Ann Arbor, Michigan 48105, USA

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-cell connection in the gene-targeting era . Diabetes 59 2991 – 2993 . ( doi:10.2337/db10-1149 ) Scott MM Lachey JL Sternson SM Lee CE Elias CF Friedman JM Elmquist JK 2009 Leptin targets in the mouse brain . Journal of Comparative Neurology

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0404
Volume/Issue:
Volume 223: Issue 1
Free access
Jackson Nteeba Department of Pathology and Laboratory Medicine, Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas, USA

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Kaiyu Kubota Department of Pathology and Laboratory Medicine, Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas, USA

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Wenfang Wang Department of Clinical Laboratory Sciences, University of Kansas Medical Center, Kansas City, Kansas, USA

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Hao Zhu Department of Clinical Laboratory Sciences, University of Kansas Medical Center, Kansas City, Kansas, USA

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Jay L Vivian Department of Pathology and Laboratory Medicine, Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas, USA

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Guoli Dai Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA

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Michael J Soares Department of Pathology and Laboratory Medicine, Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas, USA
Center for Perinatal Research, Children’s Research Institute, Children’s Mercy, Kansas City, Missouri, USA

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were used to generate chimeric mice via injection into C57BL/6 blastocysts by the Transgenic and Gene Targeting Facility of the University of Kansas Medical Center. Chimeras with an extensive agouti contribution were backcrossed with C57BL/6 mice, and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0518
Volume/Issue:
Volume 241: Issue 1
Free access
A D Adamson
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D Jackson
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J R E Davis Faculty of Life Sciences, Developmental Biomedicine Research Group, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK

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DNA . Journal of Biological Chemistry 283 4595 – 4601 doi:10.1074/jbc.M709121200 . Hendrickson EA 2008 Gene targeting in human somatic cells . In Source Book of Models for Biomedical Research , pp 509 – 525 . Ed. Conn PM . Totowa, NJ

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0417
Volume/Issue:
Volume 208: Issue 3
Free access
Yuxin Xie School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Lianhe Chu School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Yun Liu School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Kathy W Y Sham School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Jianzhen Li School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
College of Life Sciences, Northwest Normal University, Lanzhou, China

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Christopher H K Cheng School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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gonadotropins . Endocrinology 151 2349 – 2360 . ( doi:10.1210/en.2009-1227 ) 10.1210/en.2009-1227 20308533 Huang P Xiao A Zhou MG Zhu ZY Lin S Zhang B 2011 Heritable gene targeting in zebrafish using customized TALENs . Nature

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0079
Volume/Issue:
Volume 234: Issue 3
Free access
H J Novaira Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949-900 Rio de Janeiro, Brazil
Department of Medicine-Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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D S Ornellas Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949-900 Rio de Janeiro, Brazil
Department of Medicine-Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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T M Ortiga-Carvalho Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949-900 Rio de Janeiro, Brazil
Department of Medicine-Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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X M Zhang Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949-900 Rio de Janeiro, Brazil
Department of Medicine-Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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J Souza-Menezes Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949-900 Rio de Janeiro, Brazil
Department of Medicine-Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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S E Guggino Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949-900 Rio de Janeiro, Brazil
Department of Medicine-Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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W B Guggino Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949-900 Rio de Janeiro, Brazil
Department of Medicine-Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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M M Morales Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949-900 Rio de Janeiro, Brazil
Department of Medicine-Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

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Journal of Physiology Gastrointestinal and Liver Physiology 276 G491 –G498. Grubb BR & Boucher RC 1999 Pathophysiology of gene-targeted mouse models for cystic fibrosis. Physiology Reviews 79 S193 –S214

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06460
Volume/Issue:
Volume 189: Issue 1
Free access