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Jennifer A Evans Department of Biomedical Sciences, Marquette University, Milwaukee, WI, USA

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timing of these rhythms is programed by a biological clock and influenced by sleep ( Czeisler & Klerman 1999 ). Over the last few decades, we have gained a deep understanding of the mechanisms that produce circadian timekeeping at the molecular and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0054
Volume/Issue:
Volume 230: Issue 1
Free access
Shannon M Bailey Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology

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Uduak S Udoh Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology

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Martin E Young Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology

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becoming increasingly clear is that behavior-independent endogenous mechanisms also contribute toward daily rhythms in metabolism; one such mechanism is the cell autonomous circadian clock, which allows the cell to anticipate a predictable daily stimulus

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0200
Volume/Issue:
Volume 222: Issue 2
Free access
Jonathan D Johnston Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK

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Debra J Skene Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK

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both circadian time and day-length, enabling it to influence both daily and seasonal rhythms in many species. Melatonin is synthesised by multiple tissues in the body, but the pineal gland is the major contributor to circulating melatonin concentration

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0119
Volume/Issue:
Volume 226: Issue 2
Free access
Jodi L Downs Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006 and Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, USA

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Henryk F Urbanski Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006 and Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, USA

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rhythmicity or an attenuation of the amplitude of many circadian rhythms appears to be a characteristic of aging ( Schwartz 1993 , Touitou et al. 1997 , Touitou & Haus 2000 , Downs et al. 2001 , Pandi-Perumal et al. 2002 , Urbanski et al. 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06745
Volume/Issue:
Volume 190: Issue 1
Free access
Isis Gabrielli Barbieri de Oliveira Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Marcos Divino Ferreira Junior Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Paulo Ricardo Lopes Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Dhiogenes Balsanufo Taveira Campos Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Marcos Luiz Ferreira-Neto Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil

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Eduardo Henrique Rosa Santos Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil

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Paulo Cezar de Freitas Mathias Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil

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Flávio Andrade Francisco Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil

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Bruna Del Vechio Koike Medical Department, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil

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Carlos Henrique de Castro Department of Physiological Science, Integrative Laboratory of Cardiovascular and Neurological Pathophysiology, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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André Henrique Freiria-Oliveira Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Gustavo Rodrigues Pedrino Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Rodrigo Mello Gomes Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Daniel Alves Rosa Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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relate to increased adiposity and the development of other parameters of metabolic syndrome ( Báez-Ruiz et al. 2017 ). Although many evidence suggests that the desynchronization of circadian rhythm increases the risk of cardiometabolic disorders

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0026
Volume/Issue:
Volume 242: Issue 2
Free access
J Fahrenkrug Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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B Georg Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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J Hannibal Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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H L Jørgensen Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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Introduction There is growing evidence that endocrine body rhythms including the hypothalamic–pituitary–thyroid (HPT) axis are regulated by the circadian timing system, which consists of the master pacemaker located in the hypothalamic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0111
Volume/Issue:
Volume 233: Issue 3
Open access
Pei-Jian He Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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Masami Hirata Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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Nobuhiko Yamauchi Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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Masa-aki Hattori Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

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Introduction Circadian rhythm is generated by genetically determined biological clock, and is prominently entrained by cues from the 24-h light:darkness cycle ( Dunlap 1999 , Reppert & Weaver 2001 ). In mammals, the central clock is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0172
Volume/Issue:
Volume 194: Issue 3
Free access
Marianna Minnetti Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Valeria Hasenmajer Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Riccardo Pofi Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Mary Anna Venneri Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Krystallenia I Alexandraki Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Andrea M Isidori Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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adrenal hormones play a pivotal role in mitigating or enhancing the effects of clock genes on their own targets. The exact role of glucocorticoids in this context has yet to be fully elucidated. However, it is generally accepted that their circadian rhythm

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0066
Volume/Issue:
Volume 246: Issue 2
Free access
Shanqi Fu Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Miho Kuwahara Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yoko Uchida Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Sei Kondo Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Daichi Hayashi Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yuji Shimomura Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Asami Takagaki Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Takashi Nishida Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yusuke Maruyama Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan

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Mika Ikegame Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Atsuhiko Hattori Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan

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Satoshi Kubota Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Takako Hattori Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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receptors and developmental control genes ( Reddi 1994 , Goldring et al. 2006 , Shao et al. 2006 , Liu et al. 2017 ). There is considerable evidence to suggest that cartilage and bone growth in vertebrates oscillate in a circadian rhythm, but the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0022
Volume/Issue:
Volume 241: Issue 2
Free access
Sarika Paul Centre for Biological Timing, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK

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Timothy M Brown Centre for Biological Timing, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK

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function ( Takahashi 2015 ). In the case of the SCN, these clock controlled genes include membrane ion channels, thereby generating pronounced circadian rhythms in the excitability and spontaneous electrical activity of SCN neurons ( Belle & Allen 2018

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0302
Volume/Issue:
Volume 243: Issue 1
Free access