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Wang Xiao, Fei Beibei, Shen Guangsi, Jiang Yu, Zhang Wen, Huang Xi and Xu Youjia

been reported ( Jia et al . 2012 , He et al . 2013 ) and reactive oxygen species (ROS) were involved in iron-induced osteopenia ( Li et al . 2012 ). ROS attenuate osteoblastogenesis, decrease osteoblast/osteocyte lifespan, and are required for

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Ebrahim Asadi, Atefeh Najafi, Ashraf Moeini, Reihaneh Pirjani, Gholamreza Hassanzadeh, Saideh Mikaeili, Ensieh Salehi, Emmanuel Adutwum, Mansoureh Soleimani, Fariba Khosravi, Mahmood Barati and Farid Abolhassani

species (ROS) play important roles in in vitro follicular growth and maturation ( Agarwal & Allamaneni 2004 , Wiener-Megnazi et al . 2004 ). Reactive oxygen species such as hydrogen peroxide, superoxide anion and hydroxyl radicals are generated during

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Mattias Gäreskog and Parri Wentzel

-Walker et al. 2005 ). It has been suggested that PKC-δ is involved in stabilizing p53 proteins ( Lee et al. 2006 ) and related to reactive oxygen species production ( Domenicotti et al. 2003 ), both of which would ultimately lead to apoptotic cell death

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Sylvie Poncin, Ides M Colin and Anne-Catherine Gérard

Introduction Reactive species include both reactive oxygen species (ROS) and reactive nitrogen species (RNS). In all cell types, ATP generation by mitochondrial aerobic respiration generates ROS as by-products of oxidative phosphorylations. In

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Ke Ke, Ok-Joo Sul, Soo-Wol Chung, Jae-Hee Suh and Hye-Seon Choi

western blotting was performed using monoclonal HRP-conjugated anti-FLAG M2 (Sigma). Measurement of intracellular reactive oxygen species Intracellular ROS were detected using the fluorescent probe 2′,7′-dichlorofluorescein diacetate (H 2 DCFDA

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Sergio Di Meo, Susanna Iossa and Paola Venditti

production of radicals and other reactive oxygen species (ROS) is an early event in the development of IR ( Houstis et al. 2006 ) suggests that mitochondrial dysfunction is a complication of the hyperlipidemia-induced ROS production, which might promote

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S M J Scullion, E Gurgul-Convey, M Elsner, S Lenzen, P R Flatt and N H McClenaghan

cardiovascular disease: a critical review of the epidemiologic evidence . Annals of Internal Medicine 131 363 – 375 . Elsner M Gurgul-Convey E Lenzen S 2006 Relative importance of cellular uptake and reactive oxygen species for the toxicity of

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Andrea Anedda, Eduardo Rial and M Mar González-Barroso

couple . Free Radical Biology and Medicine 38 12 – 23 . Cannon B Shabalina IG Kramarova TV Petrovic N Nedergaard J 2006 Uncoupling proteins: a role in protection against reactive oxygen species – or not? Biochimica et Biophysica Acta

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Clara Lefranc, Malou Friederich-Persson, Roberto Palacios-Ramirez and Aurelie Nguyen Dinh Cat

obesity, stimulates the synthesis of pro-inflammatory cytokines, as well as bioactive substances called ‘adipokines’, which increase generation of reactive oxygen species (ROS) ( Fernández-Sánchez et al. 2011 ). Indeed, inflammation, oxidative stress and

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Sergio Di Meo, Susanna Iossa and Paola Venditti

cellular sites, including cytosol, endoplasmic reticulum, peroxisomes and lysosomes ( Venditti et al . 2015 , Di Meo et al . 2016 ), lead to partial oxygen reduction and formation of free radicals and other reactive oxygen species (ROS). ROS include