abundance ( Johnson et al. 2002 , 2003 ) in term amnion and chorion laeve. PGHS-2 gene activity, however, did not change in the two tissues during labour, suggesting that post-transcriptional mechanism(s) were involved in the labour-associated increase of
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Renée F Johnson, Carolyn M Mitchell, Warwick B Giles, Andrew Bisits and Tamas Zakar
Mei-Fway Iu, Hiroshi Kaji, Hideaki Sowa, Junko Naito, Toshitsugu Sugimoto and Kazuo Chihara
on the transcriptional activity induced by Smad3 In order to examine the mechanism by which Dex suppresses TGF-β–Smad3 pathways, we investigated whether Dex affects the transcriptional activity induced by TGF-β as well as Smad3 in MC3T3-E1
Jun-Ping Wen, Chune Liu, Wen-Kai Bi, Ya-Ting Hu, Qingshi Chen, Huibing Huang, Ji-Xing Liang, Lian-Tao Li, Li-Xiang Lin and Gang Chen
compartmentalization of SP1 in GT1-7 cells. To test this hypothesis, we evaluated KISS1 gene transcription levels in response to adiponectin, as well as AMPKα1-SiRNA, 5-aminoimidazole-4-carboxamide riboside (AICAR), and Compound C, which regulate the activity of AMPK
Botao Du, Masahide Ohmichi, Kazuhiro Takahashi, Jun Kawagoe, Chika Ohshima, Hideki Igarashi, Akiko Mori-Abe, Maki Saitoh, Tsuyoshi Ohta, Akira Ohishi, Masakazu Doshida, Naohiro Tezuka, Toshifumi Takahashi and Hirohisa Kurachi
). The effects of E 2 and raloxifene on the expression of TERT Since the telomerase activity is known to be modulated by regulation of the level of telomerase catalytic subunit (TERT) at both the transcriptional and post-transcriptional levels
Hong-Wei Wang, Michelle Muguira, Wei-Dong Liu, Tao Zhang, Chiachen Chen, Rebecca Aucoin, Mary B Breslin and Michael S Lan
confer enhancer activity ( Shieh & Tsai 1991 ). The C1/RIPE3b1 (−118/−107 bp) binding factor regulates both pancreatic β-cell-specific and glucose-regulated transcription of the insulin gene, which includes members of the large Maf transcription factor
B Maiztegui, M I Borelli, M L Massa, H Del Zotto and J J Gagliardino
glucokinase (GK) activity, together with a marked increase of glucose metabolism in response to glucose ( Massa et al. 2001 ). It was not clear, however, whether the changes recorded in HK activity were accompanied by parallel changes in the transcription
Katsumori Segawa, Morihiro Matsuda, Atsunori Fukuhara, Kentaro Morita, Yosuke Okuno, Ryutaro Komuro and Iichiro Shimomura
was observed in mature adipocytes but not other types of cell lines. CEBPA bound to this distal enhancer, and regulated the transcriptional activity of adiponectin gene. The results also showed that a proximal region in the human adiponectin promoter
Eliane Correa-de-Santana, Bianca Fröhlich, Marta Labeur, Marcelo Páez-Pereda, Marily Theodoropoulou, Jose Luis Monteserin, Ulrich Renner and Günter K Stalla
each other ( Battle & Frank 2002 ). NFKB p65 homodimers bind to phosphothyrosine STAT3 monomers. This interaction appears to increase transcriptional activity of genes driven by specific κB elements ( Yoshida et al . 2004 ). Moreover, inhibition of
Beata Bak, Laura Carpio, Jinjing L Kipp, Pankaj Lamba, Ying Wang, Ren-Shan Ge, Matthew P Hardy, Kelly E Mayo and Daniel J Bernard
. At the earlier time points, however, activin A shifted the curve to the left relative to control, indicative of enhanced 17β-HSD1 enzymatic activity ( Fig. 1 B). Activin A directly stimulates Hsd17b1 transcription through a proximal promoter region
Carmen Sanz, Isabel Roncero, Patricia Vázquez, M Angeles Navas and Enrique Blázquez
transcriptional regulation of the GK gene in cells transiently transfected by vectors containing the promoter fused to the luciferase gene. In addition, we determined the catalytic activities of this enzyme. There is experimental evidence that GT1-7 cells are
