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A D Adamson
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D Jackson
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J R E Davis Faculty of Life Sciences, Developmental Biomedicine Research Group, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK

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–reporter constructs (such as in promoter deletion and mutagenesis assays). While stable cell lines are more likely to reflect the true nature of molecular interactions in gene regulation, especially with regard to chromatin and transcription dynamics, the generation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0417
Volume/Issue:
Volume 208: Issue 3
Free access
Abraham B Roos Respiratory Medicine Unit, Lung Research Laboratory L4:01, Department of Medicine, Karolinska Institutet, Karolinska University Hospital – Solna, 171 76 Stockholm, Sweden

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Magnus Nord Respiratory Medicine Unit, Lung Research Laboratory L4:01, Department of Medicine, Karolinska Institutet, Karolinska University Hospital – Solna, 171 76 Stockholm, Sweden

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(GREs), i.e. cis-regulatory regions of target genes ( Dahlman-Wright et al . 1990 , Luisi et al . 1991 ). Gene regulation by the GR GCs regulate various inflammatory and host defense genes in the lung through different mechanisms. Additionally, GCs

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0369
Volume/Issue:
Volume 212: Issue 3
Free access
Joachim M Weitzel Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Albrecht Institute of Microbiology, Ernst-Moritz-Arndt-University, Greifswald, Germany

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Rupert Bruckmaier Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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Marion Schmicke Clinic for Cattle, Endocrinology Laboratory, University of Veterinary Medicine Hannover, Hannover, Germany

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Armin Tuchscherer Institute of Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Franziska Koch Institute of Nutritional Physiology ‘Oskar Kellner’, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Björn Kuhla Institute of Nutritional Physiology ‘Oskar Kellner’, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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, Weitzel & Iwen 2011 ). The THRs belong to a group of transcription factors whose gene regulation function is depending on the presence or absence of their particular ligand (i.e. TH). Liganded and un-liganded THRs recruit cofactors which convert chromatin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0066
Volume/Issue:
Volume 234: Issue 2
Open access
Elizabeth K Fletcher Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
Tufts Medical Center, Boston, Massachusetts, USA

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Monica Kanki Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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James Morgan Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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David W Ray NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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Lea M Delbridge Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia

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Peter J Fuller Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Colin D Clyne Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Morag J Young Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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endogenous circadian clock signalling is associated with changes in MR-mediated gene expression. Cardiomyocyte MRs are not selective and bind glucocorticoids; aldosterone was therefore used here as a ‘pure’ MR agonist to identify MR-selective gene regulation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0584
Volume/Issue:
Volume 241: Issue 1
Free access
Brad G Hoffman
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Steven J M Jones Department of Cancer Endocrinology, Micheal Smith Genome Sciences Centre, BC Cancer Research Center, 675 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3

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revolutionize our understanding of gene regulation and transcriptional networks in endocrine tissues. In order to reconstruct transcriptional networks and to elucidate the epigenetic processes in endocrine cell development and function, it is desirable to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0526
Volume/Issue:
Volume 201: Issue 1
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P Nguyen Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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S Khurana Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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H Peltsch Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Grandbois Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Eibl Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Crispo Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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D Ansell Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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T C Tai Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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.2006.125773 ) Tai TC Wong DL 2003 Protein kinase A and protein kinase C signaling pathway interaction in phenylethanolamine N -methyltransferase gene regulation . Journal of Neurochemistry 85 816 – 829 . ( doi:10.1046/j.1471

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0244
Volume/Issue:
Volume 227: Issue 2
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Praveen Kumar Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Vishwa Mohan Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Rohit Anthony Sinha Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Megha Chagtoo Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Madan M Godbole Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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chromatin has been identified as a key epigenetic mechanism of gene regulation. VPA is in clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. However, VPA

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0168
Volume/Issue:
Volume 227: Issue 2
Free access
Claire E Hills Department of Biological Sciences, Department of Infection, Biomedical Research Institute, The University of Warwick, Coventry CV4 7AL, UK

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Paul E Squires
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Rosemary Bland
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stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells . American Journal of Physiology. Renal Physiology 294 F177 – F186 . Tsugawa T Shinohara R Nagasaka A Nakano I Takeda F Nagata M Oda N Sawai Y Hayakawa N Suzuki

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0295
Volume/Issue:
Volume 199: Issue 3
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Menghong Yan CAS Key Laboratory of Nutrition and Metabolism, CAS Center for Excellence in Molecular Cell Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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Qiwei Zhai CAS Key Laboratory of Nutrition and Metabolism, CAS Center for Excellence in Molecular Cell Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
School of Life Science and Technology, ShanghaiTech University, Shanghai, China

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fractions (<40nt) were purified from low-protein sperm and injected into control zygotes, it was found that RNAs from low-protein sperm could inhibit tRF–Gly–GCC targets in two-cell embryos, which indicates that paternal diet can affect preimplantation gene

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0185
Volume/Issue:
Volume 230: Issue 3
Free access
Charlotta Dabrosin Division of Gynaecologic Oncology, Faculty of Health Sciences, University Hospital, SE-581 85 Linköping, Sweden

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tissue in postmenopausal women. European Journal of Cancer and Clinical Oncology 22 515 –525. Zhou D , Zhou C & Chen S 1997 Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06163
Volume/Issue:
Volume 187: Issue 1
Free access