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–reporter constructs (such as in promoter deletion and mutagenesis assays). While stable cell lines are more likely to reflect the true nature of molecular interactions in gene regulation, especially with regard to chromatin and transcription dynamics, the generation
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(GREs), i.e. cis-regulatory regions of target genes ( Dahlman-Wright et al . 1990 , Luisi et al . 1991 ). Gene regulation by the GR GCs regulate various inflammatory and host defense genes in the lung through different mechanisms. Additionally, GCs
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, Weitzel & Iwen 2011 ). The THRs belong to a group of transcription factors whose gene regulation function is depending on the presence or absence of their particular ligand (i.e. TH). Liganded and un-liganded THRs recruit cofactors which convert chromatin
Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
Tufts Medical Center, Boston, Massachusetts, USA
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Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
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endogenous circadian clock signalling is associated with changes in MR-mediated gene expression. Cardiomyocyte MRs are not selective and bind glucocorticoids; aldosterone was therefore used here as a ‘pure’ MR agonist to identify MR-selective gene regulation
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revolutionize our understanding of gene regulation and transcriptional networks in endocrine tissues. In order to reconstruct transcriptional networks and to elucidate the epigenetic processes in endocrine cell development and function, it is desirable to
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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.2006.125773 ) Tai TC Wong DL 2003 Protein kinase A and protein kinase C signaling pathway interaction in phenylethanolamine N -methyltransferase gene regulation . Journal of Neurochemistry 85 816 – 829 . ( doi:10.1046/j.1471
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chromatin has been identified as a key epigenetic mechanism of gene regulation. VPA is in clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. However, VPA
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stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells . American Journal of Physiology. Renal Physiology 294 F177 – F186 . Tsugawa T Shinohara R Nagasaka A Nakano I Takeda F Nagata M Oda N Sawai Y Hayakawa N Suzuki
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School of Life Science and Technology, ShanghaiTech University, Shanghai, China
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fractions (<40nt) were purified from low-protein sperm and injected into control zygotes, it was found that RNAs from low-protein sperm could inhibit tRF–Gly–GCC targets in two-cell embryos, which indicates that paternal diet can affect preimplantation gene
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tissue in postmenopausal women. European Journal of Cancer and Clinical Oncology 22 515 –525. Zhou D , Zhou C & Chen S 1997 Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells