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Xiwen Xiong Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China

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Cuicui Zhang School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, China

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Yang Zhang Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA

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Rui Fan School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, China

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Xinlai Qian School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, China

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X Charlie Dong Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA

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Biochemical Sciences 39 72 – 81 . ( doi:10.1016/j.tibs.2013.12.002 ) Lee KY Russell SJ Ussar S Boucher J Vernochet C Mori MA Smyth G Rourk M Cederquist C Rosen ED 2013 Lessons on conditional gene targeting in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0033
Volume/Issue:
Volume 233: Issue 3
Free access
Amanda E Brandon Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

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Ella Stuart Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

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Simon J Leslie Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

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Kyle L Hoehn Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

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David E James Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

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Edward W Kraegen Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

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Nigel Turner Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

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Gregory J Cooney Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia

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related to differences in many factors, including variations in gene-targeting strategies ( Hoehn et al . 2012 ). That is, Acc2 −/− mice generated by Wakil and colleagues targeted a different exon to other groups and their mice are also engineered to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0444
Volume/Issue:
Volume 228: Issue 3
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C Suárez Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

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J Vela Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

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I García-Tornadú Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

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D Becu-Villalobos Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

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, Stapleton G, Lorraine D, Dott K, Martin C, Wang L, Hedlund E, Seckl JR, Gustafsson J-A & Lathe R 2001 Neurosteroid hydroxylase CYP7B. Vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and

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Research Article
DOI:
https://doi.org/10.1677/joe.1.05889
Volume/Issue:
Volume 185: Issue 1
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Siân E Piret Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford OX3 7LJ, UK

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Rajesh V Thakker Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford OX3 7LJ, UK

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that are similar to those in man. In addition, the coding regions of mouse and human genomes share ∼85% identity ( Waterston et al . 2002 ) and development of gene targeting methods in the mouse has facilitated the generation of mouse models for human

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0193
Volume/Issue:
Volume 211: Issue 3
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Zhenguang Zhang University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Agnes E Coutinho University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Tak Yung Man University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Tiina M J Kipari Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK

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Patrick W F Hadoke University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Donald M Salter Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK

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Jonathan R Seckl University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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.1161/ATVBAHA.111.241364 22207732 Clausen BE Burkhardt C Reith W Renkawitz R Forster I 1999 Conditional gene targeting in macrophages and granulocytes using LysMcre mice . Transgenic Research 8 265 – 277 . ( doi:10.1023/A

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0223
Volume/Issue:
Volume 234: Issue 3
Open access
Da-Long Ren Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Ai-Ai Sun Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Ya-Juan Li Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Min Chen Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Shu-Chao Ge Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Bing Hu Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Zebrafish arylalkylamine-N-acetyltransferase genes-targets for regulation of the circadian clock . Journal of Molecular Endocrinology 36 337 – 347 . ( doi:10.1677/jme.1.01893 ) Barrett P Bolborea M 2012 Molecular pathways involved in seasonal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0329
Volume/Issue:
Volume 227: Issue 1
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Véronique Serre-Beinier Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Christian Toso Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Philippe Morel Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Carmen Gonelle-Gispert Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Christelle Veyrat-Durebex Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Françoise Rohner-Jeanrenaud Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Calandra Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Roger Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Richard W James Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Xavier Montet Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Léo Bühler Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Domenico Bosco Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Berney Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Hospitalier Universitaire Vaudois, Lausanne, Switzerland). MIF−/− B6×129/Sv mice were generated by gene targeting as described previously ( Bozza et al . 1999 ). These mice were backcrossed for seven generations onto a B6 background. MIF−/− mice were

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DOI:
https://doi.org/10.1677/JOE-09-0342
Volume/Issue:
Volume 206: Issue 3
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V Rider
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T Potapova
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G Dai
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M J Soares
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( Lundberg & Weinberg 1998 ). There are two E-type cyclins that share 75% amino acid sequence similarity within the cyclin box and are normally co-expressed in proliferating cells ( Geng et al. 2001 ). Mice lacking both cyclin E1 and cyclin E2 by gene

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05957
Volume/Issue:
Volume 184: Issue 1
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Diana Choi Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

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Stephanie A Schroer Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

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Shun Yan Lu Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

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Erica P Cai Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

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Zhenyue Hao Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

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Minna Woo Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

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the course of diabetes development are therefore important for the prevention and treatment of diabetes. Gene targeting strategies can provide valuable tools to study the physiological function and pathophysiological role of individual apoptotic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0073
Volume/Issue:
Volume 210: Issue 3
Free access
A Santillo Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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L Burrone Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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S Falvo Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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R Senese Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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A Lanni Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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G Chieffi Baccari Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, via Vivaldi, 43, 81100 Caserta, Italy

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reaction contained 12.5 μl iQSYBR green Supermix (code 170-8882, Bio-Rad Laboratories), 2 μl cDNA template and 6 nmol/l primers. The expression of individual gene targets was analysed using the MyiQ2 Real-time PCR machine (Bio-Rad Laboratories). The

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0127
Volume/Issue:
Volume 219: Issue 1
Free access