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Biochemical Sciences 39 72 – 81 . ( doi:10.1016/j.tibs.2013.12.002 ) Lee KY Russell SJ Ussar S Boucher J Vernochet C Mori MA Smyth G Rourk M Cederquist C Rosen ED 2013 Lessons on conditional gene targeting in
Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
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Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
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Diabetes and Metabolism Division, St Vincent's Clinical School, School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, School of Molecular Bioscience and Sydney Medical School, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
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related to differences in many factors, including variations in gene-targeting strategies ( Hoehn et al . 2012 ). That is, Acc2 −/− mice generated by Wakil and colleagues targeted a different exon to other groups and their mice are also engineered to
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, Stapleton G, Lorraine D, Dott K, Martin C, Wang L, Hedlund E, Seckl JR, Gustafsson J-A & Lathe R 2001 Neurosteroid hydroxylase CYP7B. Vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and
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that are similar to those in man. In addition, the coding regions of mouse and human genomes share ∼85% identity ( Waterston et al . 2002 ) and development of gene targeting methods in the mouse has facilitated the generation of mouse models for human
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.1161/ATVBAHA.111.241364 22207732 Clausen BE Burkhardt C Reith W Renkawitz R Forster I 1999 Conditional gene targeting in macrophages and granulocytes using LysMcre mice . Transgenic Research 8 265 – 277 . ( doi:10.1023/A
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Zebrafish arylalkylamine-N-acetyltransferase genes-targets for regulation of the circadian clock . Journal of Molecular Endocrinology 36 337 – 347 . ( doi:10.1677/jme.1.01893 ) Barrett P Bolborea M 2012 Molecular pathways involved in seasonal
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Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Hospitalier Universitaire Vaudois, Lausanne, Switzerland). MIF−/− B6×129/Sv mice were generated by gene targeting as described previously ( Bozza et al . 1999 ). These mice were backcrossed for seven generations onto a B6 background. MIF−/− mice were
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( Lundberg & Weinberg 1998 ). There are two E-type cyclins that share 75% amino acid sequence similarity within the cyclin box and are normally co-expressed in proliferating cells ( Geng et al. 2001 ). Mice lacking both cyclin E1 and cyclin E2 by gene
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Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Ontario Cancer Institute, Institute of Medical Science, Department of Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
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the course of diabetes development are therefore important for the prevention and treatment of diabetes. Gene targeting strategies can provide valuable tools to study the physiological function and pathophysiological role of individual apoptotic
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reaction contained 12.5 μl iQSYBR green Supermix (code 170-8882, Bio-Rad Laboratories), 2 μl cDNA template and 6 nmol/l primers. The expression of individual gene targets was analysed using the MyiQ2 Real-time PCR machine (Bio-Rad Laboratories). The