Search Results

You are looking at 21 - 30 of 515 items for :

  • User-accessible content x
Clear All
Free access

Linda Ahlkvist, Bilal Omar, Anders Valeur, Keld Fosgerau, and Bo Ahrén

Introduction Islet dysfunction in type 2 diabetes is bi-hormonal involving both defective insulin secretion and augmented glucagon secretion ( Unger & Orci 1975 ), the latter resulting in chronic elevation of circulating glucagon levels ( Larsson

Free access

L van Bloemendaal, J S ten Kulve, S E la Fleur, R G Ijzerman, and M Diamant

), oxyntomodulin (OXM) and glucagon-like peptide 1 (GLP-1), have been identified as players in the regulation of feeding by relaying meal-related information on nutritional status to the brain. Based on more than three decades of experimental evidence from rodent

Free access

Shou-Si Lu, Yun-Li Yu, Hao-Jie Zhu, Xiao-Dong Liu, Li Liu, Yao-Wu Liu, Ping Wang, Lin Xie, and Guang-Ji Wang

play is an important role in the regulation of endocrine pancreatic secretion. The intestinal products of the proglucagon gene, glucagon-like peptide-1 (GLP-1), has been shown to contribute significantly to the overall insulin response to oral glucose

Free access

Antonella Amato, Sara Baldassano, Rosa Liotta, Rosa Serio, and Flavia Mulè

Introduction Glucagon-like peptide 1 (GLP1), produced by intestinal enteroendocrine L-cells in response to the ingestion of nutrients ( Schirra et al . 1996 ), is highly insulinotropic and an inhibitor of gastrointestinal motility, effects that

Free access

Sara Baldassano, Anna Lisa Bellanca, Rosa Serio, and Flavia Mulè

Introduction Glucagon-like peptide 2 (GLP2) is a 33-amino acid peptide, produced by the processing of the proglucagon gene within the mucosal L-cells of the intestine and specific neurons located in the brainstem. The actions of GLP2 are transduced

Free access

Li Wang, Yufeng Zhao, Baosong Gui, Rongguo Fu, Feng Ma, Jun Yu, Ping Qu, Lei Dong, and Chen Chen

insulin resistance, causing an increase in blood glucose level ( Weir & Bonner-Weir 2004 , Prentki & Nolan 2006 , Wajchenberg 2007 ). The islet α-cell also regulates blood glucose level by secreting glucagon, which activates gluconeogenesis to increase

Free access

Sara Baldassano, Antonella Amato, Francesco Cappello, Francesca Rappa, and Flavia Mulè

, including the proglucagon-derived peptides, glucagon-like peptide-1 (GLP1), and GLP2, and there is evidence for a link among GLP2, intestinal growth, and increased energy intake ( Xiao et al . 1999 , Shin et al . 2005 , Nelson et al . 2008 ). GLP2 is a

Free access

Guillaume Mabilleau, Marie Pereira, and Chantal Chenu

needed, to reach an HbA 1C level of 7% or less. Among the most prescribed drugs, the glucagon-like peptide-1 receptor agonists (GLP-1RAs) have recently attracted attention as Glp-1r -knockout animals, and GLP-1-supplemented animals exhibited

Free access

Jennifer A Crookshank, Daniel Serrano, Gen-Sheng Wang, Christopher Patrick, Baylie S Morgan, Marie-France Paré, and Fraser W Scott

proteins were used: insulin (Agilent Technologies Canada Inc., Mississauga, Canada), proinsulin (Bio-Techne, Minneapolis, USA), glucagon (MilliporeSigma), BIP (Abcam Inc.). ImageJ (National Institute of Health) was used to quantify the insulin + and

Free access

Guillaume Mabilleau, Aleksandra Mieczkowska, Nigel Irwin, Peter R Flatt, and Daniel Chappard

al . 2010 ). Glucagon-like peptide-1 (GLP1) is a gut hormone synthesized and secreted into the blood stream by intestinal endocrine L cells in response to a variety of stimuli ( Wu et al . 2010 ). Biologically active GLP1 is secreted as a 7–37 or 7