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M J F Newson Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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G R Pope Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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E M Roberts Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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S J Lolait Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A-M O'Carroll Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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. Journal of Biological Chemistry 279 26274 – 26279 . ( doi:10.1074/jbc.M404149200 ) Jaszberenyi M Bujdoso E Telegdy G 2004 Behavioural, neuroendocrine and thermoregulatory actions of apelin-13 . Neuroscience 129 811 – 816 . ( doi:10

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Michael J F Newson Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Emma M Roberts Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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George R Pope Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Stephen J Lolait Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Anne-Marie O'Carroll Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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-immunoreactivity in the rat hypothalamus and pituitary . Neuroscience Letters 327 193 – 197 . Droste SK Chandramohan Y Hill LE Linthorst ACE Reul JMHM 2007 Voluntary exercise impacts on the rat hypothalamic–pituitary–adrenocortical axis mainly at

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Anne-Marie O'Carroll Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Stephen J Lolait Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Louise E Harris Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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George R Pope Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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-1427 ) Brailoiu GC Dun SL Yang J Ohsawa M Chang JK Dun NJ 2002 Apelin-immunoreactivity in the rat hypothalamus and pituitary . Neuroscience Letters 327 193 – 197 . ( doi:10.1016/S0304-3940(02)00411-1 ) Burbach JP Luckman SM Murphy D

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R H Straub
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L B Tankó Laboratory of Neuroendocrino-Immunology, Center for Clinical and Basic Research, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany

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C Christiansen Laboratory of Neuroendocrino-Immunology, Center for Clinical and Basic Research, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany

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P J Larsen Laboratory of Neuroendocrino-Immunology, Center for Clinical and Basic Research, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany

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D S Jessop Laboratory of Neuroendocrino-Immunology, Center for Clinical and Basic Research, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany

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selectively inhibits production of tumor necrosis factor alpha and interleukin-6 correction of interlukin-6 in astrocytes . International Journal of Developmental Neuroscience 17 765 – 775 . Kizildere S Glück T Zietz B Schölmerich J Straub RH

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Z Zhang Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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P H Bisschop Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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E Foppen Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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H C van Beeren Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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A Kalsbeek Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience (NIN), Amsterdam, Amsterdam, the Netherlands

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A Boelen Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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E Fliers Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands

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.emboj.7601882 ) Swanson LW Sawchenko PE 1983 Hypothalamic integration: organization of the paraventricular and supraoptic nuclei . Annual Review of Neuroscience 6 269 – 324 . ( doi:10.1146/annurev.ne.06.030183.001413 ) Tu HM Legradi G

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A J Forhead Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK

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A L Fowden Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK

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of the staff of the Department of Physiology, Development and Neuroscience who have helped with our studies over the years. Some of the research by the authors described here was funded by the BBSRC. References Akturk M Oruc AS Danisman N Erkek

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L A Nolan Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A Levy Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Neuroscience 2 894 – 897 . Candolfi M Zaldivar V Jaita G Seilicovich A 2006 Anterior pituitary cell renewal during the estrous cycle . Frontiers of Hormone Research 35 9 – 21 . Carbajo-Perez E Watanabe YG 1990 Cellular proliferation

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Alison J Forhead
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Juanita K Jellyman
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Katherine Gillham
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Janelle W Ward
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Dominique Blache Department of Physiology, Faculty of Natural and Agricultural Sciences, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK

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Abigail L Fowden
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, Development and Neuroscience, University of Cambridge who provided technical assistance in this study. References Alwan S Polifka JE Friedman JM 2005 Angiotensin II receptor antagonist treatment during pregnancy . Birth Defects Research 73 123

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Francesca Spiga
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Louise R Harrison
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Susan Wood
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David M Knight
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Cliona P MacSweeney Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Pharmacology, Department of Molecular Pharmacology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, BS1 3NY Bristol, UK

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Fiona Thomson Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Pharmacology, Department of Molecular Pharmacology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, BS1 3NY Bristol, UK

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Mark Craighead Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Pharmacology, Department of Molecular Pharmacology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, BS1 3NY Bristol, UK

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Stafford L Lightman
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C, Campbell-Wan L, Watson M & Craighead M 2007 In vitro and in vivo characterisation of a novel antagonist for the type 1B vasopressin receptor (V1B (V3)). Abstract of the 37th Annual Meeting of the Society for Neuroscience, 4–7 November 2007

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Jodi L Downs Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006 and Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, USA

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Henryk F Urbanski Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006 and Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, USA

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Effect of aging and caloric restriction on circadian hormone release in female rhesus macaques. Society for Neuroscience 35th Annual Meeting , Washington, DC, USA, prog. 521.15 (Abstract). Balligand JL , Brichard SM, Brichard

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