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Juan Pedro Martinez-Barbera
Juan Pedro Martinez-Barbera
Developmental Biology and Cancer Programme, Institute of Child Health, Birth Defects Research Centre, University College London, 30 Guilford Street, WC1N 1EH London, UK
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-catenin-accumulating clusters are unique to ACP and are not present in any other pituitary tumours, including the papillary form of CP ( Hofmann et al . 2006 ). In addition, the Wnt/β-catenin pathway was shown to be active in the cell clusters, as was revealed by the
Pouneh K Fazeli
Pouneh K Fazeli
Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 457, Boston, Massachusetts 02114, USA
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Anne Klibanski
Anne Klibanski
Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 457, Boston, Massachusetts 02114, USA
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Introduction Insulin-like growth factor 1 (IGF1) is a hormone produced primarily by the liver and regulated by growth hormone (GH) secretion by the somatotroph cells of the anterior pituitary gland. Many, but not all, of the actions of GH are
Sunita M C De Sousa
Sunita M C De Sousa
Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Nèle F Lenders
Nèle F Lenders
Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Lydia S Lamb
Lydia S Lamb
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Warrick J Inder
Warrick J Inder
Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Australia
Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
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Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
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Ann McCormack
Ann McCormack
Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Introduction The pituitary gland, residing in the bony sella turcica, is composed of the anterior lobe (adenohypophysis) derived from oral ectoderm and the posterior lobe (neurohypophysis) derived from neuroectoderm. The anterior lobe contains
Eun Jig Lee
Eun Jig Lee
Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
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J Larry Jameson
J Larry Jameson
Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
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. Gene therapy for endocrine disorders, including pituitary diseases, is still at an early stage. Although a variety of pre-clinical models have been examined, there have been no attempts to use gene therapy for the treatment of pituitary diseases in
Abby J Sarkar
Abby J Sarkar
Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA
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Kirti Chaturvedi
Kirti Chaturvedi
Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA
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Cui Ping Chen
Cui Ping Chen
Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA
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Dipak K Sarkar
Dipak K Sarkar
Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901, USA
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occurring neoplasms in the human pituitary ( Hardy et al. 1980 ), are vascularized tumors in some animal models ( Gorczyca & Hardy 1988 , Schecter et al. 1988 ). In the human pituitary, a relationship between increased vascularity and several aspects of
Hyun Joon Kim
Hyun Joon Kim
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Mary C Gieske
Mary C Gieske
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Kourtney L Trudgen
Kourtney L Trudgen
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Susan Hudgins-Spivey
Susan Hudgins-Spivey
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Beob Gyun Kim
Beob Gyun Kim
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Andree Krust
Andree Krust
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Pierre Chambon
Pierre Chambon
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Jae-Wook Jeong
Jae-Wook Jeong
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Eric Blalock
Eric Blalock
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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CheMyong Ko
CheMyong Ko
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Division of Reproductive Sciences, Department of Anatomy and Neurobiology, Department of Biology, Department of Animal Science and Environment, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, Institut Clinique de la Souris, Department of Obstetrics, Department of Molecular and Biomedical Pharmacology, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
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Introduction The ovarian steroid estradiol (E 2 ) plays a critical physiological role in inducing the LH surge by acting on both the hypothalamus and the pituitary ( Clarke 2002 , Christian et al . 2005 ). While much focus has been placed on the
Mone Zaidi
Mone Zaidi
The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Maria I New
Maria I New
The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Harry C Blair
Harry C Blair
The Pittsburgh VA Medical Center and Departments of Pathology and of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
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Alberta Zallone
Alberta Zallone
Department of Histology, University of Bari, Bari, Italy
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Ramkumarie Baliram
Ramkumarie Baliram
The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Terry F Davies
Terry F Davies
The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Christopher Cardozo
Christopher Cardozo
The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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James Iqbal
James Iqbal
The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Li Sun
Li Sun
The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Clifford J Rosen
Clifford J Rosen
Maine Medical Center Research Institute, Scarborough, Maine, USA
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Tony Yuen
Tony Yuen
The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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Introduction It has become increasingly clear that pituitary hormones that have traditionally been seen as regulators of single bodily processes, including endocrine functions, have additional roles in physiology. The global deletion of these
Liliana del V Sosa
Liliana del V Sosa
Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina
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Juan P Petiti
Juan P Petiti
Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina
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Florencia Picech
Florencia Picech
Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina
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Sabrina Chumpen
Sabrina Chumpen
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, CIQUIBIC-CONICET, Cordoba, Argentina
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Juan P Nicola
Juan P Nicola
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, CIBICI-CONICET, Cordoba, Argentina
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Pablo Perez
Pablo Perez
Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina
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Ana De Paul
Ana De Paul
Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina
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Javier Valdez-Taubas
Javier Valdez-Taubas
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, CIQUIBIC-CONICET, Cordoba, Argentina
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Silvina Gutierrez
Silvina Gutierrez
Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina
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Alicia I Torres
Alicia I Torres
Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica – Consejo Nacional de Investigaciones Científicas Técnicas (CONICET) Instituto de Investigaciones en Ciencias de la Salud, Córdoba, Argentina
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tumours, such as pituitary adenomas ( Spady et al . 1999 ). Most of the effects of oestrogen are mediated through its two receptors: oestrogen receptor alpha (ERα) and beta (ERβ) ( Mitchner et al . 1998 ). ERα expression has been detected in both normal
Kyriaki S Alatzoglou
Kyriaki S Alatzoglou
Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
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Daniel Kelberman
Daniel Kelberman
Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
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Mehul T Dattani
Mehul T Dattani
Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
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Introduction The pituitary gland is a central regulator of growth, metabolism, reproduction and homeostasis. It consists of three lobes: the anterior and the later-involuting intermediate lobe form the adenohypophysis, while the neurohypophysis
Takahiro Nemoto
Takahiro Nemoto
Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
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Azusa Iwasaki-Sekino
Azusa Iwasaki-Sekino
Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
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Naoko Yamauchi
Naoko Yamauchi
Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
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Tamotsu Shibasaki
Tamotsu Shibasaki
Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
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specific affinities for the CRF 2 receptor ( Hsu & Hsueh 2001 , Reyes et al. 2001 ). An immunohistochemical study has shown that Ucn 2-like immunoreactivity is present in the posterior pituitary and atria of mice ( Hsu & Hsueh 2001 ), while
