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David A Taylor-Fishwick, Wenjing Shi, Gary L Pittenger, and Aaron I Vinik

ubiquitous transcription factor PAN-1(E47) resulted in a five-fold increase in INGAP-promoter regulated β-galactosidase activity. Additionally, the consequence of combining transcription factors was explored. Expression plasmids for multiple transcription

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Alena Nareika, Yeong-Bin Im, Bryan A Game, Elizabeth H Slate, John J Sanders, Steven D London, Maria F Lopes-Virella, and Yan Huang

activities of AP-1, nuclear factor κB (NFκB), and early growth response 1, which play an important role in the transcriptional activation of genes involved in inflammation. In addition to the effect of high glucose on gene expression as described above, our

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Robert L Moore and Douglas V Faller

activation via resveratrol, in conjunction with exposure to estrogen or SIRT1 inhibitors, did not significantly reduce ERα transcriptional activity when compared with estrogen- or SIRT1 inhibitor-treated controls (data not shown). To confirm that this effect

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Jinwon Eo, Kyuyong Han, Kenneth M Murphy, Haengseok Song, and Hyunjung Jade Lim

availability in controlling target genes, while their activity may also be regulated by post-translational modification. Some of the known target genes of Etv4 transcription factors are Fshr , Ptgs2 , stromelysin, osteopontin, matrilysin, and urokinase

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C Giuliani, M Saji, I Bucci, G Fiore, M Liberatore, D S Singer, F Monaco, L D Kohn, and G Napolitano

associated with these elements, and the silencer element acts as a dominant region, whereby the insulin/IGF-I regulates the promoter tissue-specific activity. In this study, we further show that in FRTL-5 thyroid cells the transcription factors

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Kazunori Kageyama, Komaki Hanada, Yasumasa Iwasaki, Satoru Sakihara, Takeshi Nigawara, John Kasckow, and Toshihiro Suda

increased CRF or AVP transcriptional activity in parallel with increases in intracellular cAMP ( Nikodemova et al . 2003 ). In the present study, we asked whether PACAP is involved in the responses of CRF and AVP promoter activities in the hypothalamic 4B

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John Le Lay and Roland Stein

, mutation of the high-affinity A3 element resulted in slightly enhanced activity compared with the WT construct (Fig. 3 ). These results indicate that PDX-1 binding to GG2 is critical to human insulin gene transcription in islet β cells

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Lisa L Koorneef, Jan Kroon, Eva M G Viho, Lucas F Wahl, Kim M L Heckmans, Marloes M A R van Dorst, Menno Hoekstra, René Houtman, Hazel Hunt, and Onno C Meijer

the complex can bind to the DNA to induce or repress gene expression, generally involving parallel regulation of hundreds of genes. Eventual GR transcriptional activity is influenced by ligand concentration, receptor levels and the presence of

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Gary B Silberstein, Katharine Van Horn, Eva Hrabeta-Robinson, and Jennifer Compton

transcription was delayed several hours after the estrogen pulse and followed a nadir in cognate protein in the cytoplasm. Proteasome chymotrypsin activity during the estrous cycle Collectively, our findings are consistent

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Itsuo Murakami, Sakae Takeuchi, Toshiyuki Kudo, Shizuyo Sutou, and Sumio Takahashi

also induces the activation of POMC mRNA transcription ( von Dreden et al. 1988 ) and POMC promoter activity ( Kovalovsky et al. 2002 ). Activation of the PKA pathway also induces ERK1/2 (MAPK) cascade activation on POMC -gene expression