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Birgitte N Friedrichsen, Nicole Neubauer, Ying C Lee, Vivian K Gram, Niels Blume, Jacob S Petersen, Jens H Nielsen, and Annette Møldrup

Introduction The intestinal incretin hormones, glucagon-like peptide-1 (7–36) amide (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are released in response to fat and carbohydrate ingestion. Both peptides act to augment

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Jun-ichi Eiki, Kaori Saeki, Norihiro Nagano, Tomoharu Iino, Mari Yonemoto, Yoko Takayenoki-Iino, Satoru Ito, Teruyuki Nishimura, Yoshiyuki Sato, Makoto Bamba, Hitomi Watanabe, Kaori Sasaki, Sumika Ohyama, Akio Kanatani, Toshio Nagase, and Toshihiko Yada

Introduction Glucagon-like peptide-1 (GLP-1) is a hormone secreted from enteroendocrine L-cells, and is well recognized as an incretin that induces insulin secretion in a glucose-dependent manner ( Drucker 2006 ). The functions of GLP-1 have been

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Mi-Hyun Kim, Jae-Hwan Jee, Sunyoung Park, Myung-Shik Lee, Kwang-Won Kim, and Moon-Kyu Lee

Introduction Glucagon-like peptide (GLP)-1 is an intestinal hormone that exerts its effects in the regulation of glucose metabolism, the stimulation of pancreatic insulin secretion, proinsulin gene expression, and the proliferation and anti

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B D Green, N Irwin, V A Gault, C J Bailey, F P M O’Harte, and P R Flatt

Introduction The incretin hormone glucagon-like peptide-1 (GLP-1) has potent insulinotropic effects on pancreatic β-cells, and further promotes glucose lowering by enhancing glucose uptake and glyconeogenesis in peripheral tissues

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Can Liu, Mian Zhang, Meng-yue Hu, Hai-fang Guo, Jia Li, Yun-li Yu, Shi Jin, Xin-ting Wang, Li Liu, and Xiao-dong Liu

, it is noteworthy that local high concentration of ginsenosides in intestine may interact with intestinal epithelium, where numerous endocrine cells are located. Glucagon-like peptide-1 (GLP1), secreted by enteroendocrine L-cells, is one of the most

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Colin W Hay, Elaine M Sinclair, Giovanna Bermano, Elaine Durward, Mohammad Tadayyon, and Kevin Docherty

Introduction Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by the enteroendocrine L-cells of the small intestine in response to food intake ( Kieffer & Habener 1999 , Drucker 2001 ). GLP-1 plays an important role in

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Shin-ya Ueda, Takahiro Yoshikawa, Yoshihiro Katsura, Tatsuya Usui, and Shigeo Fujimoto

number of gastrointestinal hormones, such as peptide YY (PYY) and glucagon-like peptide-1 (GLP-1 or GCG as listed in the HUGO Database; Huda et al . 2006 , Näslund & Hellström 2007 , Wren & Bloom 2007 ). PYY is recognized as a satiety factor

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L Bai, G Meredith, and B E Tuch

Introduction Glucagon-like peptide-1 (GLP-1) is a peptide secreted from the gut in response to food. It acts directly on β cells, enhancing the effect of glucose in stimulating insulin secretion from these cells. When administered to

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Benjamin J Lamont and Sofianos Andrikopoulos

Introduction The incretins glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) act via specific G-protein-coupled receptors to potentiate insulin secretion from pancreatic β-cells in a glucose-dependent manner

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Bo Ahrén, Maria Sörhede Winzell, and Giovanni Pacini

glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP; Vilsboll & Holst 2004 , Drucker 2006 ). The effect is, however, also partially achieved by autonomic nerves activated by oral glucose. Thus, cholinergic nerves