Search Results

You are looking at 31 - 40 of 2,253 items for :

  • "enhancers" x
  • User-accessible content x
Clear All
Free access

Won Bae Kim, Christopher J Lewis, Kelly D McCall, Ramiro Malgor, Aimee D Kohn, Randall T Moon, and Leonard D Kohn

2004 ). β-Catenin, a transcription cofactor that acts together with T cell factor/lymphoid enhancing factor (TCF/LEF) to induce target gene expression ( Cadigan & Nusse 1997 ), is a structural adaptor protein linking cadherins to the actin cytoskeleton

Free access

Guohong Liu, Mirta Grifman, James Macdonald, Peter Moller, Flossie Wong-Staal, and Qi-Xiang Li

and type II diabetes are associated with lower levels of plasma adiponectin. Weight loss and therapy with thiazolidinediones, the drugs that enhance insulin sensitivity through stimulation of peroxisome proliferators-activated receptor-γ (PPARγ

Free access

Akiko Katoh, Hiroaki Fujihara, Toyoaki Ohbuchi, Tatsushi Onaka, W Scott Young III, Govindan Dayanithi, Yuka Yamasaki, Mitsuhiro Kawata, Hitoshi Suzuki, Hiroki Otsubo, Hideaki Suzuki, David Murphy, and Yoichi Ueta

generation and characterisation of rats that faithfully express an AVP-enhanced green fluorescent protein (eGFP) fusion transgene ( Avp – eGfp ; Ueta et al . 2005 ). In these rats, eGFP fluorescence was observed in the supraoptic nucleus (SON), the

Free access

Alena Nareika, Yeong-Bin Im, Bryan A Game, Elizabeth H Slate, John J Sanders, Steven D London, Maria F Lopes-Virella, and Yan Huang

increased generation of reactive oxygen species by polymorphonuclear leucocytes ( Mohanty et al . 2000 , Aljada et al . 2004 , 2006 ). Furthermore, it was demonstrated that increased glucose level was associated with an enhanced transcriptional

Free access

Nasser Al-Shanti and Claire E Stewart

, Moon et al . 2007 ), we therefore hypothesise that administration of PD98059 to C2 skeletal myoblast cultures may enhance cell differentiation relative to controls. The purpose of the present study described herein was to examine a potential positive

Free access

Yen-Shen Lu, Pei-Yen Yeh, Shuang-En Chuang, Ming Gao, Min-Liang Kuo, and Ann-Lii Cheng

-Bax (sc-493), anti-Bcl-2 (sc-492), anti-Bcl-X L (sc-1041), anti-p21 Cip1 (sc-817), anti-MKP-1 (sc-1102), anti-phospho-ERK (sc-7383), and anti-GR (sc-1003). Signals were visualized with an enhanced chemiluminescence kit (Amersham) followed by exposure to

Free access

Sachie Asamizu, Masaharu Urakaze, Chikaaki Kobashi, Manabu Ishiki, Amal Khalifa Norel Din, Shiho Fujisaka, Yukiko Kanatani, Agussalim Bukahari, Satoko Senda, Hikari Suzuki, Yuh Yamazaki, Minoru Iwata, Isao Usui, Katsuya Yamazaki, Hiroshi Ogawa, Masashi Kobayashi, and Kazuyuki Tobe

production and examine the effect of Ang II co-stimulation with TNF-α on MCP-1 production in 3T3-L1 preadipocytes because preadipocytes are a major source of MCP-1 production in adipose tissue. We demonstrate herein, for the first time that Ang II enhances

Free access

Tsuneo Kobayashi, Takayuki Matsumoto, and Katsuo Kamata

affect smooth muscle cell migration and proliferation ( Bornfeldt et al. 1992 , Duan et al. 2000 , Delafontaine et al. 2004 ). Moreover, chronic overexpression of IGF-I in transgenic mice results in enhanced aortic and cardiac contractility ( Zhao

Free access

Bao-Wei Wang, Hang Chang, Peiliang Kuan, and Kou-Gi Shyu

provides a negative feedback mechanism to control the size of the tissue producing it ( Gaussin & Depre 2005 ). We hypothesized that myostatin may act as a cardiac endocrine inhibitor for AngII. Myocyte enhance factor 2 (MEF-2) transcription factors are

Free access

Tracy Xiao Cui, Roland Kwok, and Jessica Schwartz

model for understanding mechanisms of GH-regulated gene transcription ( Cesena et al . 2007 ). The c- fos promoter contains multiple GH-responsive enhancer elements ( Fig. 1 A), including the sis-inducible element (SIE), serum-response element (SRE