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Inducible gene targeting in mice . Science 269 1427 – 1429 . Lam J Leppert J Vemulapalli S Shvarts O Belldegrun A 2006 Secondary hormonal therapy for advanced prostate cancer . Journal of Urology 175 27 – 34 . Liu J Grinberg A
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binding protein by gene targeting technology . Molecular and Cellular Biology 23 2489 – 2500 . Mussi P Liao L Park S-E Ciana P Maggi A Katzenellenbogen BS Xu J O'Malley BW 2006 Haploinsufficiency of the corepressor of estrogen
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
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; Yu et al. 2002 ). When we standardized these values by their pancreatic insulin content at this age ( Tsunekawa et al. 2005 ), ≈4.9 times overexpression of calmodulin was achieved by the gene targeting. The overexpression rate is relatively not
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Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
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, Schwenk F, Aguet M & Rajewsky K 1995 Inducible gene targeting in mice. Science 269 1427 –1429. Landin-Wilhelmsen K , Wilhelmsen L, Lappas G, Rosén T, Lindstedt G, Lundberg P-A & Bengtsson B-Å 1994 Serum insulin
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). Furthermore, a requirement of the progesterone receptor for ovulation in mice has been demonstrated using gene targeting technology ( Lydon et al. 1995 , 1996 ). Although data in the mouse support a potential role for progesterone-mediated regulation of a
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). Animals Male mice deficient in the V1b vasopressin receptor were generated by gene targeting as described previously ( Tanoue et al. 2004 ). Briefly, by homologous recombination, we disrupted exon 1, which contains the translation initiation
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-gene cluster and the Dlx3 promoter by C/EBPβ in cells of trophoblast origin requires further study. An important gene target of Dlx3 is the human glycoprotein hormone α subunit gene promoter expressed in trophoblast cells ( Roberson et al. 2001 ). The α
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, Deng C, Sahu A, Lambris JD & Song WC 1999 Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. PNAS 96 628 –633. Ushigoe K , Irahara M
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increase hybrid vigor as well as the increasing use of the Cre/LoxP system (which requires a tissue-specific Cre expressing and a LoxP-containing gene targeted mouse), the result0ant genetically modified mouse is frequently a conglomeration of two or more
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protein-coding genes in C57BL/6 mouse ES cells by 2021 ( Collins et al . 2007 ). The IKMC-targeted mutagenesis techniques involve use of bacterial artificial chromosome (BAC)-based ‘Knockout-First’ conditional ready gene targeting vectors that use