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Ricardo J Samms, Michelle Murphy, Maxine J Fowler, Scott Cooper, Paul Emmerson, Tamer Coskun, Andrew C Adams, Alexei Kharitonenkov, Francis J P Ebling, and Kostas Tsintzas

additional weight. Even in long-term high-fat diet studies where some increase in food intake can be observed in Siberian hamsters, this does not result in weight gain, rather the animals increase thermogenesis via increased sympathetic nervous system (SNS

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Antonius Plagge, Gavin Kelsey, and Emily L Germain-Lee

obesity, increased body weight, hyperlipidaemia, hyperglycaemia, glucose intolerance, hyperinsulinaemia, insulin resistance, reduced energy expenditure (hypometabolic) •Variable mental retardation and neurological symptoms •Reduced SNS

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Carsten T Herz and Florian W Kiefer

A; PKG: protein kinase G; POMC, pro-opiomelanocortin; PTH, parathyroid hormone; PTHR, parathyroid hormone receptor; PTHRP, parathyroid hormone-related peptide; SAM, sympathetic neuron-associated macrophage; SkM, skeletal muscle; SNS, sympathetic