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Toyama Prefectural Institute for Pharmaceutical Research, Toyama, Japan
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JST, PRESTO, Saitama, Japan
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Toyama Prefectural Institute for Pharmaceutical Research, Toyama, Japan
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maintenance of host homeostasis. Accumulating evidence has been untangling the complex link between insulin resistance in obesity and innate immunity, particularly via macrophages ( Lackey & Olefsky 2016 ). The macrophage is known to express at least two types
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-induced excessive cellular stress conditions, NADPH oxidase (NOX)-derived reactive oxygen species (ROS) are increased and accelerate macrophage polarization to proinflammatory macrophage M1 and activation. In particular, activated macrophages are recognized as
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metabolism present in innate immune cells and the role and effects of intracellular TH metabolism in these cells. It focuses specifically on the phagocytic innate immune cells: neutrophils, macrophages and dendritic cells. Thyroid hormone production and
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Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
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) activation promote steatosis–NASH progression ( Tilg & Moschen 2010 ). Lipid overload in the liver enhances lipid peroxidation, leading to reactive oxygen species (ROS) production. Enhanced lipid peroxidation and ROS production activates T cells, macrophages
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, Kim et al . 2014 ). Chronic inflammation is characterised by enhanced cytokine levels (e.g. interleukin 1β (IL1β), IL6, IL10 and tumour necrosis factor alpha (TNFα)), and oxygen free radicals generated by immune cells, such as activated macrophages
Institute of Gerontology, The University of Tokyo, Tokyo, Japan
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, in the present study, we sought to unravel the effects of testosterone on AAA formation and found that castration promoted AAA formation through exacerbated infiltration of inflammatory macrophages and Il-6 and Il-1b upregulation. Conversely
Department of Clinical Sciences, University of Barcelona, Barcelona, Spain
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Department of Clinical Sciences, University of Barcelona, Barcelona, Spain
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Department of Clinical Sciences, University of Barcelona, Barcelona, Spain
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Department of Clinical Sciences, University of Barcelona, Barcelona, Spain
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Department of Clinical Sciences, University of Barcelona, Barcelona, Spain
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pancreata were double stained and counted as described for grafts. CD68, IL-1β, and iNOS immunohistochemistry To identify the presence of macrophages, we stained CD68-expressing cells (monocyte/macrophage lineage
Department of Medicine, Faculty of Medical and Human Sciences, Department of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Thorn Bldg, 1405, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
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( Wu et al . 2011 ), and macrophages ( Weisberg et al . 2003 , Lumeng et al . 2007 , Wentworth et al . 2010 ). Resident adipose leukocyte populations represent distinct subsets, with particular functions compared with their equivalent populations
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin, Germany
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progresses, Kupffer cells are replaced by monocyte-derived macrophages. Also, other immune cells as neutrophils and Type 1 T helper cells contribute to the inflammatory environment in NASH. However, also anti-inflammatory effects of immune cells in NASH are
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-induced adipose tissue inflammation in the development of T1D in the LEW1.WR1 rat. Our data demonstrate for the first time that infection with a diabetogenic virus leads to CD68 + macrophage infiltration into visceral but not subcutaneous adipose tissue observed