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Laboratory of Pharmacological Neuroendocrinology, Department of Pharmacology and Toxicology, Biotechnology Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia
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Introduction Atosiban is a known antagonist of oxytocin and vasopressin receptors and is clinically used to decrease preterm uterine activity and preterm labor ( Goodwin et al . 1994 , Usta et al . 2011 ). Generally, atosiban is considered to be
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, androstenedione, estradiol, oxytocin, inhibin A, inhibin B, insulin-like growth factor-I (IGF-I), transforming growth factor-2β (TGF-2β) and an IGF-binding protein (IGFBP-3) by these cells. The involvement of a PKA-dependent pathway in mediating TPO action was
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stimulus, which elicits robust secretion of oxytocin and prolactin responsible for milk ejection and production respectively, is also known to modify gonadotropin secretion. It is generally accepted that the effects of the suckling stimulus on gonadotropin
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Introduction Hydroelectrolytic homeostasis is maintained by several endocrine and behavioral responses that control sodium appetite, water ingestion, and the secretion of oxytocin (OT) and vasopressin (AVP) from the neurohypophysis ( Fitzsimons 1998
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Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, Jilin, China
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Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, Jilin, China
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Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, Jilin, China
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( Sympson et al. 1994 , Fata et al. 2001 , Ning et al. 2007 ). Oxytocin receptor (OXTR) is a G-protein-coupled receptor for neurotransmitter oxytocin ( Kimura et al. 1992 ). In response to ligand binding, activated OXTR couples to G αq/11 and G
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blood collected into heparinized tubes. Samples were maintained on ice and then centrifuged (3000 g , 4 °C, 30 min) to allow collection of plasma for subsequent determination of vasopressin (AVP) and oxytocin (OT) levels by RIA ( Samson 1985 , Samson
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Introduction The arginine-vasopressin (AVP)/oxytocin (OT) neuro-endocrine system is widely distributed in the animal kingdom. In vertebrates, more than 10 related peptides and over 30 related receptors belonging to the G