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Biological Sciences, Chronic Disease Program, Departments of Obstetrics and Gynaecology and Cellular and Molecular Medicine, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6
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restriction (IUGR; Jackson et al . 1995 , Salafia et al . 1995 ), and preeclampsia ( Redman & Sargent 2005 ). During the formation of the placenta in primates and rodents, the epithelium of the uterus is eroded by embryonic trophoblasts, which eventually
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-6736(89)90710-1 ) Chatmethakul T Roghair RD 2019 Risk of hypertension following perinatal adversity: IUGR and prematurity . Journal of Endocrinology 242 T21 – T32 . ( https://doi.org/10.1530/JOE-18-0687 ) 10.1530/JOE-18-0687) Chattergoon NN 2019 Thyroid
The Farncombe Family Digestive Diseases Research Institute, McMaster University, Hamilton, Canada
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The Farncombe Family Digestive Diseases Research Institute, McMaster University, Hamilton, Canada
Department of Pediatrics and Obstetrics and Gynecology, McMaster University, Hamilton, Canada
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females Numerous studies have shown that FGR or intrauterine growth restriction (IUGR) is associated with altered development and reproductive dysfunction in offspring ( Cooper et al. 1996 , Sloboda et al. 2007 , Ibanez et al. 2011 ). Indeed low
Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
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. 1992 , Fisher 1997 ). A variety of thyroid hormone transporters are expressed in the human placenta and show changes during normal development and in cases of intrauterine growth restriction (IUGR; Chan et al . 2009 , Loubiere et al . 2010 ). In
Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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of vascular remodeling by EVT, also known as physiologic change, in maternal spiral arterioles, leading to such complications as miscarriage, early-onset severe preeclampsia (eo-sPE) and intrauterine growth restriction (IUGR) ( Fisher 2015 ). While
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Adelaide Medical School, University of Adelaide, Adelaide, Australia
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia
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Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Table 1). Adverse effects of GH administration have also been reported in a subset of studies. Suppressed maternal appetite has been reported in sheep and pigs, particularly when high doses of GH are started in late pregnancy. In a model of IUGR
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restriction (IUGR), pre-eclampsia and spontaneous abortion ( Kumar & Chaudhuri 1989 , Abalovich et al . 2002 , Mestman 2004 , Casey et al . 2005 , LaFranchi et al . 2005 , Kilby et al . 2005 , Pillar et al . 2010 , Luewan et al . 2011 ). Studies
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Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
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School of Agriculture, Food and Wine, University of Adelaide, Adelaide, South Australia, Australia
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Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
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The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia
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The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia
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Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
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( DeFronzo & Tripathy 2009 ). The M. vastus lateralis is a mixed-fibre type muscle, and we have previously reported that intra-uterine growth restriction (IUGR) impairs gene expression of determinants of insulin signalling in this muscle in sheep ( De Blasio
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Introduction Epidemiological studies initially demonstrated that adverse environmental factors leading to intrauterine growth retardation (IUGR) and low birth weight may predispose individuals to the later onset of development of pathologies related
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& Meaney 2004 ). Secondly, endogenous fetal plasma cortisol concentrations are increased in pregnancies where there has been intrauterine growth restriction (IUGR; Goland et al. 1993 ). In normal pregnancies maternal plasma cortisol at term is ~200 ng