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621 – 626 . Hriscu M 2004 Circadian phagocytic activity of neutrophils and its modulation by light . Journal of Applied Biomedicine 2 199 – 211 . Hriscu M Saulea G Vidrascu N Baciu I 1998 Circadian rhythm of phagocytosis in mice
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surge generator requires information regarding the light–darkness environment ( Freeman 1994 ); a circadian rhythm generated in the hypothalamic suprachiasmatic nucleus in response to light–darkness cycles entrains the GnRH surge generator to produce the
Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
Tufts Medical Center, Boston, Massachusetts, USA
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Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
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peripheral tissue to anticipate environmental stimuli ( Takahashi & Zatz 1982 ). The GR and MR are not expressed in the SCN but the GR serves as a zeitgeber of the circadian clock in peripheral tissues ( Kino & Chrousos 2011 a ). Circadian rhythm is driven
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patterns observed in most depressed patients and the recent licensing of agomelatine, which re-synchronizes disrupted circadian rhythms ( Yous et al . (1992) , for review, see de Bodinat et al . (2010) ). In line with this, it was recently shown in
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same daily rhythmicity in its synthesis as observed for pineal melatonin. However, these daily patterns are particular to each species. For example, in goldfish, gut melatonin synthesis shows a clear circadian rhythm that is in phase with that of the
Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA
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Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA
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Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA
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Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
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Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
Mental Retardation Research Center, University of California, Neurosciences Research Building, 655 Charles Young Drive South, Los Angeles, California 90095-7088, USA
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Institut National de la Santé et de la Recherche Médicale U676, Hôpital Robert-Debré, 48 Boulevard Sérurier, F-75019 Paris, France
Department of Physiology and Pharmacology L334, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97201-3098, USA
Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
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demonstrated that the dark–light circadian rhythm is damaged in VIP null mice ( Colwell et al. 2003 ), suggesting that rhythmic secretion of gonadotropins might be perturbed in VIP KO mice. Altogether, these data strongly favor the idea that the lack of VIP
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cones ( Lucas & Foster 1999 ), indicating a role for the non-image-forming photoreceptor OPN4 in melatonin inhibition by light and circadian rhythms. The OPN4 photoreceptor is involved in both circadian re-setting mechanisms and pupillary light
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et al . 2015 ), at least partly via influencing adrenocortical ACTH sensitivity ( Oster et al . 2006 , Leliavski et al . 2014 ). How circadian rhythms affect the adaptive response to repeated and, importantly, predictable stressor exposure, though
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mimic their respective humoral circadian rhythms for an additional 4 weeks. Slow-release melatonin (Chronocaps; Productos Medix S.A. de C.V., México City, México) pill fragments equivalent to a concentration of 2.5 mg/kg and corticosterone (HBC complex
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HPG axis is dormant and ovulation does not occur, suggesting the shutdown of kisspeptin signaling, reduced GnRH neuron or gonadotrope sensitivity, or a combination of each. We therefore speculate that disruption of normal hypothalamic circadian rhythms