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Jonathan J Nicholls Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Mary Jane Brassill Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Graham R Williams Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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J H Duncan Bassett Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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action in bone, such approaches cannot identify the in vivo cell targets of T 3 action and the application of cell-specific gene-targeting strategies is now required. Skeletal development During endochondral ossification, mesenchyme

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0059
Volume/Issue:
Volume 213: Issue 3
Free access
Sarah J Meachem Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Saleela M Ruwanpura Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Jessica Ziolkowski Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Jacquelyn M Ague Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Michael K Skinner Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Kate L Loveland Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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uncovered, some of which may be indirectly regulated by altered levels of available FSH or represent bona fide novel FSH-regulated genes. Targets not previously identified in the testis include aminolevulinic acid synthase 2 and melanoma inhibitory activity

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06121
Volume/Issue:
Volume 186: Issue 3
Free access
Juan Sun Department of Medicine, The University of Chicago, Chicago, Illinois, USA

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Liqun Mao Department of Medicine, The University of Chicago, Chicago, Illinois, USA

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Hongyan Yang Department of Gynecology, Key Research Laboratory of Gynecology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China

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Decheng Ren Department of Medicine, The University of Chicago, Chicago, Illinois, USA
Department of Gynecology, Key Research Laboratory of Gynecology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China

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Shostak A , et al . 2010 Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain . Diabetes 59 3090 – 3098 . ( https://doi.org/10.2337/db10-0624 ) 10.2337/db10-0624 20802254 Wittenberg

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0015
Volume/Issue:
Volume 238: Issue 2
Free access
Marian Joëls Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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the way from the gene target to the functional consequences. The most extensively studied pathway (calcium signaling) suggests that the gene encoding for beta4 auxiliary subunits may form a preferential genetic target for GR homodimers ( Chameau et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0226
Volume/Issue:
Volume 238: Issue 3
Free access
Ljupka Gligorovska Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Biljana Bursać Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Sanja Kovačević Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Nataša Veličković Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Gordana Matić Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Ana Djordjevic Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Mitchell R Huss R Moll U Muller W Bucala R 2003 The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting . PNAS 100 9354 – 9359 . ( https://doi.org/10.1073/pnas.1533295100 ) 10.1073/pnas.1533295100 12878730

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0333
Volume/Issue:
Volume 240: Issue 2
Free access
Maria Namwanje Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Longhua Liu Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Michelle Chan Department of Biological Sciences, Columbia University, New York, New York, USA

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Nikki Aaron Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA
Department of Pharmacology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Michael J Kraakman Naomi Berrie Diabetes Center, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Li Qiang Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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S Boucher J Vernochet C Mori MA Smyth G Rourk M Cederquist C Rosen ED , 2013 Lessons on conditional gene targeting in mouse adipose tissue . Diabetes 62 864 – 874 . ( https://doi.org/10.2337/db12-1089 ) 10.2337/db12-1089 23321074 Mayoral

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0361
Volume/Issue:
Volume 240: Issue 2
Free access
Shu-Fang Xia Wuxi School of Medicine, Jiangnan University, Wuxi, China
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Xiao-Mei Duan State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China
Shandong Sport Training Center, Jinan, China

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Xiang-Rong Cheng State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Li-Mei Chen Wuxi School of Medicine, Jiangnan University, Wuxi, China

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Yan-Jun Kang Wuxi School of Medicine, Jiangnan University, Wuxi, China

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Peng Wang COFCO Corporation Oilseeds Processing Division, Beijing, China

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Xue Tang State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Yong-Hui Shi State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Guo-Wei Le State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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mice vs OP mice and putative gene targets To investigate the potential role of miRs in different propensities to HFD-induced obesity, next-generation sequencing was used in livers of OP and OR mice in the 7th week, respectively. As displayed in Table

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0044
Volume/Issue:
Volume 234: Issue 2
Free access
T V Novoselova Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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R Larder University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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D Rimmington University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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C Lelliott Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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E H Wynn Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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R J Gorrigan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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P H Tate Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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L Guasti Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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The Sanger Mouse Genetics Project Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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S O’Rahilly University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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A J L Clark Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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D W Logan Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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A P Coll University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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L F Chan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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gene targeting was confirmed by long-range PCR and quantitative PCR. Targeted ES cells were microinjected into blastocysts and used to generate chimeras. Germ-line transmission was confirmed by genotyping PCR analyses ( http

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0057
Volume/Issue:
Volume 230: Issue 1
Open access
Cuili Wang State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China

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Dongteng Liu State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China

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Weiting Chen Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China

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Wei Ge Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China

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Wanshu Hong State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China

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Yong Zhu State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Department of Biology, East Carolina University, Greenville, North Carolina, USA

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Shi X Chen State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University, Xiamen, China

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2011 Heritable gene targeting in zebrafish using customized TALENs . Nature Biotechnology 29 699 – 700 . ( doi:10.1038/nbt.1939 ) Huggard-Nelson DL Nathwani PS Kermouni A Habibi HR 2002 Molecular characterization of LH-β and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0073
Volume/Issue:
Volume 230: Issue 1
Free access
Esther Paulo Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Dongmei Wu Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Peter Hecker Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Yun Zhang Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Biao Wang Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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conditional gene targeting in mouse adipose tissue . Diabetes 62 864 – 874 . ( https://doi.org/10.2337/db12-1089 ) 10.2337/db12-1089 23321074 Lee P Werner CD Kebebew E Celi FS 2014 Functional thermogenic beige adipogenesis is inducible in human neck

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0173
Volume/Issue:
Volume 239: Issue 2
Free access