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development of nephropathy in an experimentally induced mouse model of type 2 diabetes. The latter was of particular interest based on a study by Swindell et al . (2010) looking at differential gene expression in WT vs Papp-A KO mice that highlighted the
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Introduction Type 1 diabetes (T1D) is a chronic disease characterized by severe loss of insulin secretion, requiring insulin replacement therapy for the individual’s lifetime. The disease is often diagnosed in children and adolescents, but
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contribute to insulin resistance ( Pedersen et al. 2016 ). The aromatic AAs tyrosine, phenylalanine, and tryptophan are correlated with diabetes risk ( Wang et al. 2011 , Chen et al. 2016 ). Bacteria harbor genes encoding mediators of aromatic AA
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Introduction Diabetes-related foot disease (DFD) is defined as ulceration, infection or destruction of tissues of the foot in a person with current or previously diagnosed diabetes mellitus, usually associated with the risk factors of
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European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium
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European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium
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Introduction Obesity is linked with many cardiometabolic risk factors, such as insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Although lowering body weight is effective for alleviating several of these
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current knowledge of the metabolic and vascular actions of testosterone in these disorders – specifically, how testosterone deficiency contributes to insulin resistance, metabolic syndrome, type 2 diabetes ( Kelly & Jones 2013 a ), and cardiovascular
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK
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types of fat depots: namely brown, white and beige adipose tissue ( Cypess et al . 2014 ). The latter has the largest potential as a therapeutic target in the prevention of obesity and/or diabetes. This is because, from an adult perspective, beige (or
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Introduction Type 2 diabetes (T2D) is a chronic, lifelong condition characterized by hyperglycaemia resulting from persistent insulin resistance (IR) and/or insufficient insulin production due to β-cell dysfunction or death ( Prentki & Nolan
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Washington, where she conducted type 1 diabetes research as an undergraduate McNair Scholar at Dr Ake Lernmark’s lab. She furthered her scientific passion by participating in a postbaccalaureate program at the National Cancer Institute at NIH under Dr Elise
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Preterm birth and the later risk of diabetes Preterm birth (birth before 37 completed weeks’ gestation) occurs in 11.1% of births globally, with most countries showing increasing rates over the past two decades ( Blencowe et al . 2012 ). The
