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J Svensson Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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M Diez Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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J Engel Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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C Wass Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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Å Tivesten Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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J-O Jansson Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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O Isaksson Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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T Archer Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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T Hökfelt Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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C Ohlsson Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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Unrestricted Bristol-Myers Squibb Neuroscience Grant. The authors are grateful to Professor Sven Ove Ögren and Eugenia Kuteeva for valuable advice concerning experiments with the Morris swim maze. They are also grateful to Maud Petersson, Anna-Lena Jirestedt

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Chunxiao Qi Department of Neurobiology, Hebei Medical University, Shijiazhuang, People’s Republic of China
Department of Human Anatomy, Hebei Medical University, Shijiazhuang, People’s Republic of China

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Xiaoming Ji Department of Neurobiology, Hebei Medical University, Shijiazhuang, People’s Republic of China

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Guoliang Zhang Department of Human Anatomy, Hebei Medical University, Shijiazhuang, People’s Republic of China

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Yunxiao Kang Department of Neurobiology, Hebei Medical University, Shijiazhuang, People’s Republic of China

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Yuanxiang Huang Grade 2015 Eight-year Clinical Medicine Program, School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, People’s Republic of China

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Rui Cui Department of Human Anatomy, Hebei Medical University, Shijiazhuang, People’s Republic of China

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Shuangcheng Li Department of Human Anatomy, Hebei Medical University, Shijiazhuang, People’s Republic of China

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Huixian Cui Department of Human Anatomy, Hebei Medical University, Shijiazhuang, People’s Republic of China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, People’s Republic of China

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Geming Shi Department of Neurobiology, Hebei Medical University, Shijiazhuang, People’s Republic of China
Department of Human Anatomy, Hebei Medical University, Shijiazhuang, People’s Republic of China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, People’s Republic of China

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not used in the study. All of the experimental procedures followed the rules in the ‘Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research’ and approved by the Committee of Ethics on Animal Experiments at Hebei Medical

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Rui Gao Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

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Samuel Acreman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden

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Jinfang Ma Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

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Fernando Abdulkader Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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Anna Wendt Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden

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Quan Zhang Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

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Amperometric detection of single vesicle acetylcholine release events from an artificial cell . ACS Chemical Neuroscience 6 181 – 188 . ( https://doi.org/10.1021/cn5002667 ) Kimball CP & Murlin JR 1923 Aqueous extracts of pancreas: III . Journal of

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Beverly A S Reyes Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Hiroko Tsukamura Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Helen I’Anson Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Maria Amelita C Estacio Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Kanjun Hirunagi Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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Kei-Ichiro Maeda Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA

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paraventricular nucleus and nucleus of the solitary tract during fasting in ovariectomized rats. Neuroscience Letters 208 25 –28. Estacio MAC , Tsukamura H, Reyes BAS, Uenoyama Y, I’Anson H & Maeda K-I 2004 Involvement of

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Jie Miao UMR 9197, Molecular Neuroendocrinology of Food Intake, University Paris-Sud, University Paris-Saclay, Orsay, France
Department of Molecules and Circuits, CNRS UMR 9197, Molecular Neuroendocrinology of Food Intake, Paris-Saclay Institute of Neuroscience, Orsay, France
Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China

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Yacir Benomar UMR 9197, Molecular Neuroendocrinology of Food Intake, University Paris-Sud, University Paris-Saclay, Orsay, France
Department of Molecules and Circuits, CNRS UMR 9197, Molecular Neuroendocrinology of Food Intake, Paris-Saclay Institute of Neuroscience, Orsay, France

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Sarah Al Rifai UMR 9197, Molecular Neuroendocrinology of Food Intake, University Paris-Sud, University Paris-Saclay, Orsay, France

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Ghislaine Poizat UMR 9197, Molecular Neuroendocrinology of Food Intake, University Paris-Sud, University Paris-Saclay, Orsay, France
Department of Molecules and Circuits, CNRS UMR 9197, Molecular Neuroendocrinology of Food Intake, Paris-Saclay Institute of Neuroscience, Orsay, France

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Laure Riffault UMR 9197, Molecular Neuroendocrinology of Food Intake, University Paris-Sud, University Paris-Saclay, Orsay, France
Department of Molecules and Circuits, CNRS UMR 9197, Molecular Neuroendocrinology of Food Intake, Paris-Saclay Institute of Neuroscience, Orsay, France

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Delphine Crépin UMR 9197, Molecular Neuroendocrinology of Food Intake, University Paris-Sud, University Paris-Saclay, Orsay, France
Department of Molecules and Circuits, CNRS UMR 9197, Molecular Neuroendocrinology of Food Intake, Paris-Saclay Institute of Neuroscience, Orsay, France

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Mohammed Taouis UMR 9197, Molecular Neuroendocrinology of Food Intake, University Paris-Sud, University Paris-Saclay, Orsay, France
Department of Molecules and Circuits, CNRS UMR 9197, Molecular Neuroendocrinology of Food Intake, Paris-Saclay Institute of Neuroscience, Orsay, France

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paradigms in lysosomal storage diseases . Frontiers in Neuroscience 9 417 . ( https://doi.org/10.3389/fnins.2015.00417 ) 26578874 Brunetti L Orlando G Recinella L Michelotto B Ferrante C Vacca M 2004 Resistin, but not adiponectin

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Sang-Nam Lee Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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Bonnie Peng Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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Roxane Desjardins Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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John E Pintar Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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Robert Day Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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Iris Lindberg Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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. Chronwall BM , Sands SA, Dickerson DS, Sibley DR & Gary KA 1996 Melanotrope dopamine D2 receptor isoform expression in the developing rat pituitary. International Journal of Developmental Neuroscience 14 77 –86. Crabbe JC

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David M Golding School of Biosciences, Cardiff University, Cardiff, UK

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Daniel J Rees Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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Jennifer R Davies Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Dinko Relkovic Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Hannah V Furby Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Irina A Guschina School of Biosciences, Cardiff University, Cardiff, UK

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Anna L Hopkins School of Biosciences, Cardiff University, Cardiff, UK

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Jeffrey S Davies Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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James L Resnick Center for Mammalian Genetics, University of Florida, College of Medicine, Gainesville, Florida, USA

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Anthony R Isles Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Timothy Wells School of Biosciences, Cardiff University, Cardiff, UK

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Neuroscience 42 2105 – 2113 . ( doi:10.1111/ejn.12972 ) Davies JS Kotokorpi P Eccles SR Barnes SK Tokarczuk PF Allen SK Whitworth HS Guschina IA Evans BA Mode A 2009 Ghrelin induces abdominal obesity via GHS

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K L Davies Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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E J Camm Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia

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D J Smith Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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O R Vaughan Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Institute for Women’s Health, University College London, London, UK

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A J Forhead Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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A J Murray Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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A L Fowden Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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authors thank the staff of the University Biomedical Services for their care of the animals and the technical staff of the Department of Physiology, Development and Neuroscience who assisted with this study. References Arvier M Langoutte L

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Audrey F Seasholtz Molecular and Behavioral Neuroscience Institute, University of Michigan, 109 Zina Pitcher Place, BSRB Room 5035, Ann Arbor, Michigan 48109, USA
Department of Biological Chemistry, University of Michigan, 109 Zina Pitcher Place, BSRB Room 5035, Ann Arbor, Michigan 48109, USA

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Miina Öhman Department of Psychiatry, University of Michigan, 109 Zina Pitcher Place, BSRB Room 5035, Ann Arbor, Michigan 48109, USA

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Amale Wardani Molecular and Behavioral Neuroscience Institute, University of Michigan, 109 Zina Pitcher Place, BSRB Room 5035, Ann Arbor, Michigan 48109, USA

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Robert C Thompson Molecular and Behavioral Neuroscience Institute, University of Michigan, 109 Zina Pitcher Place, BSRB Room 5035, Ann Arbor, Michigan 48109, USA
Department of Psychiatry, University of Michigan, 109 Zina Pitcher Place, BSRB Room 5035, Ann Arbor, Michigan 48109, USA

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novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression . Journal of Neuroscience 15 6340 – 6350 . Chalmers DT Lovenberg TW Grigoriadis DE

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K L Davies Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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J Miles Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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E J Camm Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia

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D J Smith Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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P Barker MRC Metabolic Diseases Unit, Mouse Biochemistry Laboratory, Cambridge Biomedical Campus, Cambridge, UK

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K Taylor Endocrine Laboratory, Blood Sciences, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK

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A J Forhead Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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A L Fowden Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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hypothalamic-pituitary-adrenal axis: development, programming actions of hormones and maternal-fetal interactions . Frontiers in Behavioral Neuroscience 14 601939 . ( https://doi.org/10.3389/fnbeh.2020.601939 ) Sloboda DM Moss TJM Gurrin LC Challis

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