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F S Raza, M Okamoto, H Takemori, and G P Vinson

series of studies ( Sayers et al. 1948 , Kitabchi 1967 , Chayen et al. 1976 , Hornsby et al. 1985 , Yanagibashi et al. 1990 ). In demonstrating the corticotrophin-dependence of the transcription, expression and activity of MnSOD specifically

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L Gómez-García, F M Sánchez, M T Vallejo-Cremades, I A Gómez de Segura, and E De Miguel del Campo

activation. Telomerase activity is closely regulated by changes in gene transcription ( Kyo et al. 2000 , Mauro & Foster 2002 ), protein–protein interactions ( Haendeler et al. 2003 ) and phosphorylation by protein kinase C, ERK1/2 and

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Qinghua Wang, Jing Tang, Shujun Jiang, Zan Huang, Anying Song, Siyuan Hou, Xiang Gao, and Hai-Bin Ruan

induction of luciferase activity by PPARγ1 in 3T3-L1 cells ( Fig. 2D ) and NIH/3T3 cells (Supplementary Fig. 1B). PPARγ binds to its own promoter and activates its own transcription ( Lefterova et al. 2008 , Nielsen et al. 2008 ). We also observed

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Ichiro Kaneko, Rimpi K Saini, Kristin P Griffin, G Kerr Whitfield, Mark R Haussler, and Peter W Jurutka

Introduction The vitamin D receptor (VDR) regulates transcription in response to its 1,25-dihydroxyvitamin D 3 (1,25D) ligand by forming a heterodimer with one of the retinoid X receptors (RXRs) and binding to vitamin D responsive elements (VDREs

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Seiji Tsutsumi, Xi Zhang, Keiko Takata, Kazuhiro Takahashi, Richard H Karas, Hirohisa Kurachi, and Michael E Mendelsohn

. * P <0.05, significantly different from the vehicle. NOS2A reporter activity in aortic VSMC and Rad arterial VSMC To confirm whether the difference of distribution of ERs affects transcriptional regulation of NOS2A, NOS2A reporter activities were

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Noriko Tagawa, Sayaka Kubota, Ikuo Kato, and Yoshiharu Kobayashi

endoplasmic reticulum is facilitated by G6P transporter (G6PT), which is found on the surface of the endoplasmic reticulum. These enzymes and carrier proteins are compartmentalized in the endoplasmic reticulum; thus, 11β-HSD1 activity substantially depends on

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Asmaà Fritah, Gérard Redeuilh, and Michèle Sabbah

upregulation of the WISP-2/CCN5 Δ-1919 promoter activity (Fig. 4E ). HE19, which contains the DBD, the ligand-binding domain and the hormone-inducible transactivating function AF-2, was inefficient at stimulating transcription from the hWISP-2/CCN5 gene

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Ruslan Rafikov, Fabio V Fonseca, Sanjiv Kumar, Daniel Pardo, Charles Darragh, Shawn Elms, David Fulton, and Stephen M Black

physiological conditions, the dominant NOS isoform in the vasculature is eNOS, which rather than being a constitutive enzyme as was first suggested, is dynamically regulated at the transcriptional, posttranscriptional, and posttranslational levels. This review

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Dieuwertje C E Spaanderman, Mark Nixon, Jacobus C Buurstede, Hetty H C M Sips, Maaike Schilperoort, Eline N Kuipers, Emma A Backer, Sander Kooijman, Patrick C N Rensen, Natalie Z M Homer, Brian R Walker, Onno C Meijer, and Jan Kroon

). Glucocorticoid action in metabolism is predominantly mediated by glucocorticoid receptors (GRs) which are expressed in virtually all tissues in both humans and rodents. It is known that glucocorticoid transcriptional activity is subject to multiple levels of

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O Gubbay, M T Rae, A S McNeilly, F X Donadeu, A J Zeleznik, and S G Hillier

experimentally induced to over-express CREB has been reported before ( Saeki et al. 1999 ). The simplest explanation is that occupancy of CRE elements on promoters by non-phosphorylated CREB would block transcription. Additionally, since PKA activity may limit