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preoptic area (POA; de la Iglesia et al . 1995 ). Transmission of the time-of-day signal from the SCN to CRH- and GnRH-synthesizing neurons is thought to be involved in the entrainment of the circadian rhythm governing the activities of the HPA and HPO
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine, Clinical Biochemistry, University of Bristol, Bristol BS1 3NY, UK
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'Carroll et al . 2003 ); understanding of the exact role in HPA functioning is only now emerging ( Newson et al . 2009 ) and the 24-h variability in plasma apelin levels in this study did not match the typical cortisol circadian rhythm. We found a reduction
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, Indredavik et al . 2004 , Raikkonen et al . 2008 , Schendel & Bhasin 2008 ). These disorders are associated with abnormalities of the hypothalamic–pituitary–adrenal (HPA) axis such as disturbed circadian rhythm, impaired cortisol suppression by
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
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Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
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Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
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Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
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Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
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where it affects circadian rhythm, and in the seminiferous tubules of the testis ( Wechselberger et al . 1999 , Melchiorri et al . 2001 , Cheng et al . 2002 , LeCouter et al . 2003 a , b ). Moreover, the distinct patterns of expression of both
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. Ahima RS & Flier JS 2000 Leptin. Annual Review of Physiology 62 413 –437. Ahima RS , Prabakaran D & Flier JS 1998 Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Journal of Clinical
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circadian rhythms. The absence of light stimulates melatonin production, leading to sleep facilitation. During the daytime, the light stimulus is processed by the retina and sent to the suprachiasmatic nucleus, inhibiting melatonin synthesis and promoting
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reproductive functions, and is a classical stress hormone ( Gimpl & Fahrenholz 2001 , Landgraf & Neumann 2004 ). Plasma OXT displays a distinct circadian rhythm and changes during stress response, parturition and lactation, as well as upon pharmacological use
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( Table 1 ). In humans, the plasma concentrations of CBG (~500 nM) and cortisol (~50–500 nM over the circadian rhythm) are similar between sexes at all ages ( Robinson et al. 1985 , Russell & Lightman 2019 ). During physical trauma in humans, plasma
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caspase-3. In addition, a significant reduction in the histological damage of renal tubules was apparent. Another problem observed after kidney transplantation is the disturbance in circadian rhythms and sleep–wake cycles including poor sleep quality
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Gerontology and Geriatrics, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium
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males is primarily mediated by ERα, though this does not exclude the possibility that ERβ plays a role in modulating the circadian-rhythm patterns of activity, as shown for females ( Royston et al. 2014 ). ‘Non-classical’ ER knock-in (NERKI) mice