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Christoph Melcher Institute for Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany

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Ruediger Bader Institute for Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany

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Michael J Pankratz Institute for Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany

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-like phenotype. The gene encodes a zinc finger transcription factor and is expressed throughout the nervous system. Microarray analysis focusing on neuropeptide gene regulation indicated that hugin was upregulated in klu mutants; hugin is expressed

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Trinna L Cuellar UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, California 94122-0534, USA

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Michael T McManus UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, California 94122-0534, USA

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Dicer is required for morphogenesis but not patterning of the vertebrate limb. PNAS 102 10898 –10903. He L & Hannon GJ 2004 MicroRNAs: small RNAs with a big role in gene regulation. Nature Reviews Genetics 5 522

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Takaharu Maruyama Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Kenichi Tanaka Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Jun Suzuki Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Hiroyuki Miyoshi Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Naomoto Harada Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Takao Nakamura Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Yasuhisa Miyamoto Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Akio Kanatani Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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Yoshitaka Tamai Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

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expression. Physiological Reviews 81 1269 –1304. Beato M 1989 Gene regulation by steroid hormones. Cell 56 335 –344. Bjorkhem I & Eggertsen G 2001 Genes involved in initial steps of bile

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José E Sánchez-Criado Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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Carmina Bellido Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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Rafaela Aguilar Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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José C Garrido-Gracia Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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1998 Cellular distribution and gene regulation of estrogen receptors α and β in the rat pituitary gland. Endocrinology 139 3976 –3983. Mobbs CV , Fink G & Pfaff DW 1990 HIP-70: a protein induced by estrogen in the

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Jennifer H Steel Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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Roger White Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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Malcolm G Parker Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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. Subramaniam N , Treuter E & Okret S 1999 Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids. Journal of Biological Chemistry 274 18121 –18127. Torchia J , Rose DW

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Koen D Flach Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wilbert Zwart Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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sequencing coverage. Apart from forming the foundations of cis -regulatory gene regulation, chromatin looping and eRNA action, genome-wide profiling analyses of ERα sites can also lead to the identification of additional transcription factor motifs often

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Anne-Marie O'Carroll Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Stephen J Lolait Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Louise E Harris Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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George R Pope Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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in both the N-terminal (e.g. Asp 23 and Glu 20 ) and C-terminal portions of the receptor are required for internalisation ( Zhou et al . 2003 a , c , Masri et al . 2006 ). Gene regulation The regulation of APJ gene expression has not been

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Liza Margareth Medeiros de Carvalho Sousa Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Renata dos Santos Silva Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Vanessa Uemura da Fonseca Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Rafael Magdanelo Leandro Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Thiago Senna Di Vincenzo Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Ana Bárbara Alves-Wagner Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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Ubiratan Fabres Machado Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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Paula de Carvalho Papa Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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in the adipose and muscle tissues. Regarding the INSR gene regulation and gonadal hormones, E2 has already been proposed as enhancer of INSR mRNA expression in hypothalamus ( Clegg et al . 2006 ), however, nothing is known about either its

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Ying Wang Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Xiao-Hui Wang Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Deng-Xuan Fan Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Yuan Zhang Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Ming-Qing Li Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Hai-Xia Wu Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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Li-Ping Jin Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China

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A Cohen T Shinder V Land-Bracha A Amsterdam A 2004 Gonadotrophin-induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic genes, cytoskeletal genes and genes coding for apoptotic signalling

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Crystal Ying Wang Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, China

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Yajun Wang Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, China

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Amy Ho Yan Kwok Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, China

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Frederick C Leung Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, China

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Identification of the chicken growth hormone-releasing hormone receptor (GHRH-R) mRNA and gene: regulation of anterior pituitary GHRH-R mRNA levels by homologous and heterologous hormones . Endocrinology 147 2535 – 2543 . Scanes CG Harvey S 1984 Stimulation

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