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Gisela Helfer School of Chemistry and Biosciences, University of Bradford, Bradford, UK

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Qing-Feng Wu State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

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is downstream of retinoic acid signalling. Retinol enters the tanycytes where it is synthesised to retinoic acid (RA). RA enters the nucleus and binding to its receptors RAR and RXR leads to transcription of Rarres2 , which is translated into c

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Samuel M Lee Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Muratalla Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Marta Sierra-Cruz Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Cordoba-Chacon Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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damage and fibrogenesis induced by carbon tetrachloride-mediated hepatoxicity ( Moran-Salvador et al. 2013 ) ( Table 2 ). A recent study used the lecithin:retinol acyltransferase (Lrat) promoter-driven Cre mouse model ( Greenhalgh et al. 2015 ) to knock

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Shona Wood Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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Andrew Loudon Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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ES Ross AW Wilson D Plé H Mercer JG Ebling FJ Schuhler S Dupré SM 2006 Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian

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Sharon H Chou Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA

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Christos Mantzoros Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA
Section of Adult and Pediatric Endocrinology, Division of Endocrinology, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA

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Yildizhan B Kolusari A Adali E Bugdayci G 2011 Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome . Fertility and Sterility 96 246 – 250

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Mathis Grossmann Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia
Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia

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retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis . Diabetes 61 1072 – 1081 . ( doi:10.2337/db11-1136 ) McLachlan RI 2010 Certainly more guidelines than rules . Journal of Clinical

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Ferran Jardí Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Michaël R Laurent Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
Gerontology and Geriatrics, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Vanessa Dubois Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Nari Kim Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Rougin Khalil Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Brigitte Decallonne Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Dirk Vanderschueren Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Frank Claessens Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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://doi.org/10.1016/j.physbeh.2007.07.010 ) 10.1016/j.physbeh.2007.07.010 McInnes KJ Smith LB Hunger NI Saunders PTK Andrew R Walker BR 2012 Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals

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Weiliang Xia Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Dolores D Mruk Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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Will M Lee Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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C Yan Cheng Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10021, USA
Department of Zoology, University of Hong Kong, Hong Kong, China

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.9 Hepcidin antimicrobial peptide NM_012733 Rbp1 1.2 4.1 Retinol-binding protein 1 Proteases/ protease inhibitors NM_031531 Spin2c 1.5 26.0 Serine protease inhibitor NM_053819 Timp1 1.7 15.0 Tissue inhibitor of metalloproteinase 1 BF411331 Serpinb1a

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Renata Risi Department of Experimental Medicine, Sapienza University of Rome, Sapienza University of Rome, Rome, Italy
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK

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Antonio Vidal-Puig University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
Cambridge University Nanjing Centre of Technology and Innovation, Nanjing, P. R. China
Centro de Investigacion Principe Felipe, Valencia, Spain

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Guillaume Bidault University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK

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and a lipid core composed of TAGs, cholesterol ester and retinol ester ( Welte & Gould 2017 ) that are detected in adult islet β cells ( Vernier et al. 2012 , Trevino et al. 2015 , Dai et al. 2016 ). LD formation starts as TAG accumulation

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Manuel D Gahete Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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David Rincón-Fernández Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Alicia Villa-Osaba Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Daniel Hormaechea-Agulla Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Alejandro Ibáñez-Costa Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Antonio J Martínez-Fuentes Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Francisco Gracia-Navarro Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Justo P Castaño Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Raúl M Luque Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Pedersen SB Moller N Jorgensen JO Jessen N 2013 Ghrelin- and GH-induced insulin resistance: no association with retinol-binding protein-4 . Endocrine Connections 2 96 – 103 . ( doi:10.1530/EC-13-0019 ) Volante M Allia E Gugliotta P Funaro A Broglio F

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F Labrie Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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V Luu-The Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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A Bélanger Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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S-X Lin Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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J Simard Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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G Pelletier Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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C Labrie Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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-hydroxysteroid dehydrogenase activity of human recombinant 11-cis-retinol dehydrogenase. Biochimica et Biophysica Acta 1547 351 –358. Huang XF & Luu-The V 2001b Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase

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