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Department of Chemistry, Center for Analysis and Synthesis, Lund University, Sweden
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Introduction Seminal work in the 1960s and 1970s established that insulin secretion is deficient in type 2 diabetes (T2D) ( Bagdade et al . 1967 , Simpson et al . 1968 ). In the last decade, a number of genome-wide association studies (GWAS
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by activating liver glycogenolysis and gluconeogenesis, which results in the release of glucose to the bloodstream. An abnormal function of these cells can generate failures in the control of glycaemia, which can lead to the development of diabetes
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Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine
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Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine
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Introduction Chronic low-grade inflammation is increasingly considered as a contributing factor to many metabolic diseases including type 2 diabetes (T2D). Obesity leads to excess fatty acids and lipids in the body, which have toxic and damaging
Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia
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Introduction: significance of the clinical problem Around 50% of ageing, obese men presenting to the diabetes clinic have lowered testosterone levels relative to reference ranges based on healthy young men ( Grossmann 2011 ). Many have symptoms
Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden
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Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden
Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden
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Type 2 diabetes: a growing epidemic Type 2 diabetes (T2D) is a syndrome characterized by disordered metabolism, resulting in hyperglycemia. The most common and dreaded long-term complication of diabetes is cardiovascular disease, which accounts for
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Introduction Gestational diabetes mellitus (GDM) prevalence is increasing in women due to the obesity epidemic; however, the ideal management of GDM remains controversial ( Mack & Tomich 2017 ). It is estimated that one out of six live births
Fourth Department of Internal Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Institute of Endocrinology, First Faculty of Medicine, Charles University, Na Bojišti 3, Prague 2 12000, Czech Republic
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Fourth Department of Internal Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Institute of Endocrinology, First Faculty of Medicine, Charles University, Na Bojišti 3, Prague 2 12000, Czech Republic
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-acting hormones ( Potthoff et al . 2012 ). Interestingly, when administered in pharmacological doses, both FGF19 and FGF21 have insulin-sensitizing and hypolipidemic effects in rodent models of obesity and type 2 diabetes (T2DM) ( Tomlinson et al . 2002
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diabetes? In this issue of Journal of Endocrinology , Dr Han and colleagues report on an exciting novel function of GDH in chronic pathological situations relevant for type 2 diabetes. They have used 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
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Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
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Introduction Diabetes mellitus (DM) is a major metabolic disorder and a global health problem currently affecting more than 250 million people worldwide ( Zimmet & Alberti 2006 ). Type 1 and type 2 DM (T1DM and T2DM) can lead to a number of long
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Introduction Type 1 diabetes (T1D) is an autoimmune disease characterized by immunocyte infiltration of the pancreatic islets (insulitis) and destruction of the insulin-secreting β cells. Diabetes in the biobreeding (BB) rat exhibits many