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Malin Fex Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Lisa M Nicholas Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Neelanjan Vishnu Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Anya Medina Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Vladimir V Sharoyko Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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David G Nicholls Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Peter Spégel Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden
Department of Chemistry, Center for Analysis and Synthesis, Lund University, Sweden

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Hindrik Mulder Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Introduction Seminal work in the 1960s and 1970s established that insulin secretion is deficient in type 2 diabetes (T2D) ( Bagdade et al . 1967 , Simpson et al . 1968 ). In the last decade, a number of genome-wide association studies (GWAS

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0367
Volume/Issue:
Volume 236: Issue 3
Free access
Ivan Quesada CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and Instituto de Bioingeniería, Universidad Miguel Hernández, Avenida de la Universidad s/n, 03202 Elche, Spain

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Eva Tudurí CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and Instituto de Bioingeniería, Universidad Miguel Hernández, Avenida de la Universidad s/n, 03202 Elche, Spain

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Cristina Ripoll CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and Instituto de Bioingeniería, Universidad Miguel Hernández, Avenida de la Universidad s/n, 03202 Elche, Spain

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Ángel Nadal CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and Instituto de Bioingeniería, Universidad Miguel Hernández, Avenida de la Universidad s/n, 03202 Elche, Spain

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by activating liver glycogenolysis and gluconeogenesis, which results in the release of glucose to the bloodstream. An abnormal function of these cells can generate failures in the control of glycaemia, which can lead to the development of diabetes

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0290
Volume/Issue:
Volume 199: Issue 1
Free access
Craig S Nunemaker Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine

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H Grace Chung Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine
Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine

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Gretchen M Verrilli Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine
Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine

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Kathryn L Corbin Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine

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Aditi Upadhye Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine

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Poonam R Sharma Division of Endocrinology and Metabolism, Department of Biomedical Engineering, Department of Biology, Department of Medicine

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Introduction Chronic low-grade inflammation is increasingly considered as a contributing factor to many metabolic diseases including type 2 diabetes (T2D). Obesity leads to excess fatty acids and lipids in the body, which have toxic and damaging

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0126
Volume/Issue:
Volume 222: Issue 2
Free access
Mathis Grossmann Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia
Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia

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Introduction: significance of the clinical problem Around 50% of ageing, obese men presenting to the diabetes clinic have lowered testosterone levels relative to reference ranges based on healthy young men ( Grossmann 2011 ). Many have symptoms

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0393
Volume/Issue:
Volume 220: Issue 3
Free access
Henrik Ortsäter Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden
Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden

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Nina Grankvist Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden

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Richard E Honkanen Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden

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Åke Sjöholm Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden
Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden
Biovation Park Telge, Research Unit, Degenerative Disease Program, Department of Biochemistry and Molecular Biology, Department of Internal Medicine, Södertälje, Sweden

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Type 2 diabetes: a growing epidemic Type 2 diabetes (T2D) is a syndrome characterized by disordered metabolism, resulting in hyperglycemia. The most common and dreaded long-term complication of diabetes is cardiovascular disease, which accounts for

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0002
Volume/Issue:
Volume 221: Issue 3
Free access
Antonio Gázquez Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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Francisca Rodríguez Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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María Sánchez-Campillo Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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Lidia E Martínez-Gascón Department of Clinical Analysis, Biomedical Research Institute of Murcia, Santa Lucia General University Hospital, Murcia, Spain

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Marino B Arnao Department of Plant Biology (Plant Physiology), University of Murcia, Murcia, Spain

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Pedro Saura-Garre Department of Clinical Psychology, University Clinical Hospital Virgen de la Arrixaca, Murcia, Spain

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María D Albaladejo-Otón Department of Clinical Analysis, Biomedical Research Institute of Murcia, Santa Lucia General University Hospital, Murcia, Spain

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Elvira Larqué Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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Introduction Gestational diabetes mellitus (GDM) prevalence is increasing in women due to the obesity epidemic; however, the ideal management of GDM remains controversial ( Mack & Tomich 2017 ). It is estimated that one out of six live births

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0617
Volume/Issue:
Volume 251: Issue 1
Open access
Libor Vítek Fourth Department of Internal Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Institute of Endocrinology, First Faculty of Medicine, Charles University, Na Bojišti 3, Prague 2 12000, Czech Republic
Fourth Department of Internal Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Institute of Endocrinology, First Faculty of Medicine, Charles University, Na Bojišti 3, Prague 2 12000, Czech Republic

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Martin Haluzík Fourth Department of Internal Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Institute of Endocrinology, First Faculty of Medicine, Charles University, Na Bojišti 3, Prague 2 12000, Czech Republic
Fourth Department of Internal Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Institute of Endocrinology, First Faculty of Medicine, Charles University, Na Bojišti 3, Prague 2 12000, Czech Republic

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-acting hormones ( Potthoff et al . 2012 ). Interestingly, when administered in pharmacological doses, both FGF19 and FGF21 have insulin-sensitizing and hypolipidemic effects in rodent models of obesity and type 2 diabetes (T2DM) ( Tomlinson et al . 2002

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0469
Volume/Issue:
Volume 228: Issue 3
Free access
Isabel Göhring Unit of Molecular Metabolism, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Clinical Research Center 91:11, SE-205 02, Malmö, Sweden

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Hindrik Mulder Unit of Molecular Metabolism, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Clinical Research Center 91:11, SE-205 02, Malmö, Sweden

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diabetes? In this issue of Journal of Endocrinology , Dr Han and colleagues report on an exciting novel function of GDH in chronic pathological situations relevant for type 2 diabetes. They have used 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0481
Volume/Issue:
Volume 212: Issue 3
Free access
Mohamed Lotfy Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Jaipaul Singh Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Hameed Rashed Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Saeed Tariq Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Erika Zilahi Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Ernest Adeghate Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Introduction Diabetes mellitus (DM) is a major metabolic disorder and a global health problem currently affecting more than 250 million people worldwide ( Zimmet & Alberti 2006 ). Type 1 and type 2 DM (T1DM and T2DM) can lead to a number of long

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0426
Volume/Issue:
Volume 220: Issue 3
Free access
Marika Bogdani
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Angela M Henschel Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Sanjay Kansra Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Jessica M Fuller Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Rhonda Geoffrey Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Shuang Jia Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Mary L Kaldunski Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Scott Pavletich Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Simon Prosser Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Yi-Guang Chen Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Åke Lernmark Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Martin J Hessner Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Introduction Type 1 diabetes (T1D) is an autoimmune disease characterized by immunocyte infiltration of the pancreatic islets (insulitis) and destruction of the insulin-secreting β cells. Diabetes in the biobreeding (BB) rat exhibits many

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0385
Volume/Issue:
Volume 216: Issue 2
Free access