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A Fratticci Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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F A Grieco Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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C Spilioti Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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F Giangaspero Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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L Ventura Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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V Esposito Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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M Piccirilli Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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A Santoro Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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A Gulino Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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G Cantore Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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E Alesse Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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M L Jaffrain-Rea Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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specific progenitor pool, or later as final differentiating factors. Though bHLH factors have been observed in the anterior adult pituitary ( Jackson et al. 1993 ), studies on the transcriptional control of pituitary development have mainly focused on

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0020
Volume/Issue:
Volume 194: Issue 3
Free access
Mio Tanaka
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Morio Azuma
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Yumika Nejigaki
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Yumiko Saito Laboratory of Regulatory Biology, Graduate School of Integrated Arts and Sciences, School of Marine Biosciences, Department of Anatomy, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama 930-8555, Japan

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Kanta Mizusawa Laboratory of Regulatory Biology, Graduate School of Integrated Arts and Sciences, School of Marine Biosciences, Department of Anatomy, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama 930-8555, Japan

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Minoru Uchiyama
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Akiyoshi Takahashi Laboratory of Regulatory Biology, Graduate School of Integrated Arts and Sciences, School of Marine Biosciences, Department of Anatomy, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama 930-8555, Japan

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Seiji Shioda Laboratory of Regulatory Biology, Graduate School of Integrated Arts and Sciences, School of Marine Biosciences, Department of Anatomy, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama 930-8555, Japan

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Kouhei Matsuda
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Introduction Melanin-concentrating hormone (MCH) was first isolated from the chum salmon pituitary during an attempt to identify a novel pituitary hormone that could modulate body colour in fish ( Kawauchi et al . 1983 , Kawazoe et al . 1987

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0330
Volume/Issue:
Volume 203: Issue 3
Free access
C Suárez Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

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J Vela Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

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I García-Tornadú Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

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D Becu-Villalobos Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

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( Poortman et al. 1975 ). In particular the relation of DHEA to pituitary function has not been clearly defined. Serum DHEA levels present a characteristic ontogenic pattern, with increasing values toward puberty and a progressive decline during

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05889
Volume/Issue:
Volume 185: Issue 1
Free access
Masafumi Amano School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Shunsuke Moriyama School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Masayuki Iigo School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Shoji Kitamura School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Noriko Amiya School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Kunio Yamamori School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Kazuyoshi Ukena School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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Kazuyoshi Tsutsui School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022-0101, Japan
Department of Applied Biochemistry, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi 321-8505, Japan
Freshwater Fisheries Research Division, National Research Institute of Fisheries Science, Nikko, Tochigi 321-1661, Japan
Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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). GnIH-immunoreactive (ir) cell bodies and terminals were localized in the paraventricular nucleus and median eminence, respectively, indicating that GnIH acts directly on the pituitary ( Tsutsui et al. 2000 , Ubuka et al. 2003 , Ukena et al. 2003

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06494
Volume/Issue:
Volume 188: Issue 3
Free access
Karen Francis
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B Mary Lewis
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Peter N Monk Centre for Endocrine and Diabetes Sciences, Academic Neurology Unit, Cardiff University, Cardiff, CF14 4XN, UK

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Jack Ham
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Introduction The hypothalamic–pituitary–adrenal (HPA) axis is a major regulator of immunity and inflammation via its secretion of glucocorticoids that suppress the immune activation of leukocytes and inhibit proinflammatory mediators. ACTH is the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0110
Volume/Issue:
Volume 199: Issue 3
Free access
Kotaro Horiguchi Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Tom Kouki Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Ken Fujiwara Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Motoshi Kikuchi Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Takashi Yashiro Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

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Introduction The anterior pituitary gland comprises five types of hormone-producing cells plus folliculo-stellate (FS) cells, which do not produce classical anterior pituitary hormones. FS cells have a star-like appearance ( Farquhar 1957 , Vila

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0297
Volume/Issue:
Volume 208: Issue 3
Free access
M Victoria Recouvreux Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

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M Andrea Camilletti Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

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Daniel B Rifkin Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

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Graciela Díaz-Torga Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

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Pituitary tumors Pituitary tumors are commonly benign, slow growing adenomas, and account for 10–15% of all intracranial neoplasms ( Farrell 2006 , Melmed 2015 ). The prevalence of these tumors is relatively high in the general population, with ∼77

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0451
Volume/Issue:
Volume 228: Issue 3
Free access
M Theodoropoulou
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T Arzberger
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Y Gruebler
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M L Jaffrain-Rea
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J Schlegel
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L Schaaf
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E Petrangeli
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M Losa
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G K Stalla
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U Pagotto
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Introduction Pituitary adenomas are benign tumors which account for 15% of all intracranial neoplasms. Despite the extensive studies performed to elucidate the molecular defects present in pituitary adenomas, their pathogenesis is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05616
Volume/Issue:
Volume 183: Issue 2
Free access
José E Sánchez-Criado Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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Carmina Bellido Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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Rafaela Aguilar Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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José C Garrido-Gracia Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain

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first exposure of the pituitary to GnRH ( de Koning et al. 1976 ). Progesterone receptor (PR) plays a key role in augmenting gonadotroph responsiveness to GnRH ( Waring & Turgeon 1992 , Turgeon & Waring 1994 ) and requires previous exposure of the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06162
Volume/Issue:
Volume 186: Issue 1
Free access
M Candolfi Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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G Jaita Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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D Pisera Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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L Ferrari Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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C Barcia Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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C Liu Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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J Yu Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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G Liu Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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M G Castro Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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A Seilicovich Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires (C1121ABG), Argentina
Gene Therapeutics Research Institute, Cedars-Sinai Medical Center and Department of Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Davis Building, Suite 5090, Los Angeles, California 90048, USA
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA

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Introduction Although most pituitary tumors are benign, aggressive local growth can occur. Altered pituitary hormone release often leads to serious clinical disorders, such as acromegaly, Cushing’s disease and sexual dysfunction

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06594
Volume/Issue:
Volume 189: Issue 3
Free access