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Kyriaki S Alatzoglou Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Daniel Kelberman Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Mehul T Dattani Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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primordium and the correct morphogenesis of the gland require the sequential temporal and spatial expression of a cascade of signalling molecules and transcription factors that will eventually dictate organ commitment, cell proliferation, patterning and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0447
Volume/Issue:
Volume 200: Issue 3
Free access
Jin Yu Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Yuhuan Liu Department of Gynecology and Obstetrics, Changhai Hospital, Naval Medical University, Shanghai, China

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Danying Zhang Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Dongxia Zhai Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Linyi Song Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Zailong Cai Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai, China

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Chaoqin Yu Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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deletion analysis and transcription factor-binding site analysis, GATA-binding factor 1 (GATA1) was identified as a transcription factor most relevant to the HSD3B2 gene expression after cells were incubated with baicalin. To further confirm these results

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0678
Volume/Issue:
Volume 240: Issue 3
Open access
R Wang
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N Yashpal
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F Bacchus
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J Li
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-Kit and the transcription factors PDX-1 and Ngn3 at the mRNA level. With the addition of the growth factor HGF, the monolayers had increased expression of insulin and glucagon mRNA, a 6.5- and 2-fold increase respectively in comparison with control

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05788
Volume/Issue:
Volume 183: Issue 1
Free access
Elizabeth K Fletcher Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
Tufts Medical Center, Boston, Massachusetts, USA

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Monica Kanki Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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James Morgan Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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David W Ray NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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Lea M Delbridge Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia

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Peter J Fuller Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Colin D Clyne Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Morag J Young Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Introduction The mineralocorticoid receptor (MR) is a ligand-activated transcription factor best known for regulating sodium/potassium and water in the kidney in response to aldosterone ( Fuller & Young 2005 ). The MR has equivalent high

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0584
Volume/Issue:
Volume 241: Issue 1
Free access
Eliane Correa-de-Santana
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Bianca Fröhlich
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Marta Labeur
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Marcelo Páez-Pereda Department of Endocrinology, Affectis Pharmaceuticals, Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Marily Theodoropoulou
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Jose Luis Monteserin
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Ulrich Renner
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Günter K Stalla
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transcription factor important for mediating the inflammatory response, tumorigenesis and anti-apoptotic effects on cells. In addition to its ability to form complexes to itself and other STATs there are several reports showing that STAT3 and NFKB interact with

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0113
Volume/Issue:
Volume 203: Issue 1
Free access
Ying-Ying Tsai Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA

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William E Rainey Departments of Molecular & Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Wendy B Bollag Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA
Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA

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absent steroid hormone production and enlarged adrenal glands. Transcription factors, such as cAMP response element-binding protein (CREB), steroidogenic factor 1 (SF-1) and adrenal hypoplasia critical region on chromosome X gene 1 (DAX-1 or NR0B1), may

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0237
Volume/Issue:
Volume 232: Issue 2
Free access
Mei-Fway Iu Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Hiroshi Kaji Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Hideaki Sowa Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Junko Naito Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Toshitsugu Sugimoto Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Kazuo Chihara Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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expression and transcription factor CBFa1 on bone cells by glucocorticoid. Journal of Biological Chemistry 273 4892 –4896. Chipuk JE , Cornelius SC, Pultz NJ, Jorgensen JS, Bonham MJ, Kim SJ & Danielpour D 2002 The androgen

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05962
Volume/Issue:
Volume 185: Issue 1
Free access
Georg Homuth
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Alexander Teumer
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Uwe Völker
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Matthias Nauck Department of Functional Genomics, Institute for Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Straße 15A, D-17487 Greifswald, Germany

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beginning, disease-relevant phenotypes were of particular interest in GWAS. However, the individual susceptibility for a given disease is only partially determined by genetic factors, and environmental influences are also of great importance, as are the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0144
Volume/Issue:
Volume 215: Issue 1
Free access
Almas R Juma Department of Physiology, Department of Clinical Sciences, Department of Human Genetics, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria 3086, Australia

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Pauliina E Damdimopoulou Department of Physiology, Department of Clinical Sciences, Department of Human Genetics, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria 3086, Australia

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Sylvia V H Grommen Department of Physiology, Department of Clinical Sciences, Department of Human Genetics, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria 3086, Australia

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Wim J M Van de Ven Department of Physiology, Department of Clinical Sciences, Department of Human Genetics, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria 3086, Australia

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Bert De Groef Department of Physiology, Department of Clinical Sciences, Department of Human Genetics, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria 3086, Australia

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Introduction The transcription factor pleomorphic adenoma gene 1 (PLAG1) was first discovered via positional cloning when researchers were studying pleomorphic adenomas of the salivary glands ( Kas et al . 1997 ). Its role in various types of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0449
Volume/Issue:
Volume 228: Issue 2
Free access
Sinead N Kelly Department of Surgery, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Department of Endocrinology and Diabetes Mellitus, St Vincent’s University Hospital, Elm Park, Dublin, Ireland

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T Joseph McKenna Department of Surgery, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Department of Endocrinology and Diabetes Mellitus, St Vincent’s University Hospital, Elm Park, Dublin, Ireland

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Leonie S Young Department of Surgery, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Department of Endocrinology and Diabetes Mellitus, St Vincent’s University Hospital, Elm Park, Dublin, Ireland

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enzymes is controlled, at least in part, by ACTH and angiotensin II (AII), signalling through specific transcription factors such as steroidogenic factor-1 (SF-1) and nur77. We have previously demonstrated that nur77 may preferentially regulate steroid

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06005
Volume/Issue:
Volume 186: Issue 1
Free access