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Chiung-Zuan Chiu, Bao-Wei Wang and Kou-Gi Shyu

under normoxia also increased UII expression ( Fig. 4 B and C). Hypoxia increases the binding between the UII promoter and AP1 transcription factor and enhances genetic transcription activity of AP1 to UII promoter in cardiomyocytes Under 2.5% O 2

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P Nguyen, S Khurana, H Peltsch, J Grandbois, J Eibl, J Crispo, D Ansell and T C Tai

, and we have previously demonstrated that the induction of PNMT gene expression in vitro upon GC administration is mediated by GC response elements (GRE) within the PNMT promoter ( Tai et al . 2002 ). Further, altered activity of the transcription

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T Taguchi, T Takao, Y Iwasaki, M Nishiyama, K Asaba and K Hashimoto

, inhibits POMC gene transcription in AtT20 cells DHEA inhibited the 5′-promoter activity of the POMC gene in dose- and time-dependent manners. Significant inhibition was observed at 50 μM or above, with the maximal suppressive effects at 24 h (Fig

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Fang Cai, Armen V Gyulkhandanyan, Michael B Wheeler and Denise D Belsham

of metabolic processes, including glucose and lipid metabolism ( Kahn et al. 2005 ). The activity of AMPK is acutely regulated in the hypothalamus by peripheral nutrient signals, and may therefore act as a central regulator of energy balance ( Kim

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Liat Abovich Gilad, Oren Tirosh and Betty Schwartz

phytoestrogens have higher binding affinity for ERβ compared with ERα ( Mueller et al. 2004 ). Genistein was found to be > 1000-fold more potent at triggering transcriptional activity with ERβ ( An et al. 2001 ), indicating that genistein has a preference for

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Ralf Baumeister, Elke Schaffitzel and Maren Hertweck

negatively regulate the FOXO transcription factor DAF-16. Inhibition of the daf-2 receptor gene expression/activity or other genes in the insulin/IGF pathway can have three effects. (A) Early developmental downregulation, which affects many biological

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Koji Nagayama, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Hiroyuki Iwaki, Hideyuki Matsunaga, Shingo Suzuki, Hiroko Misawa, Keiko Ishizuka, Yutaka Oki, Jaeduk Yoshimura Noh and Hirotoshi Nakamura

effect of E 2 -ERα on the TSHβ (−615/+37)- CAT reporter gene, which has longer TSHβ promoter encompassing nt. −615/+37, and found again that the transcriptional activity in CV1 cells was stimulated by PIT1 and GATA2, and significantly decreased by 1

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Yunshan Hu, Hong Bin Liu, Richard W Simpson and Anthony E Dear

inhibitor SR202 had no effect on suppression of TNFα-stimulated NUR77 promoter activity by rosiglitazone ( Fig. 3 b), suggesting that this transcriptional effect was PPARγ independent. Co-transfection of a PPARγ dominant-negative construct into the cells

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Gabriela Hernández-Puga, Arturo Mendoza, Alfonso León-del-Río and Aurea Orozco

, repressor of tamoxifen transcriptional activity protein, RTA, acts as a corepressor of estrogen receptor-a when bound to selective hormone response modulators like tamoxifen, but not when bound to pure agonists ( Norris et al . 2002 ). As far as we know, a

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Bo Chen, Yanrong Lu, Younan Chen and Jingqiu Cheng

activity is disrupted, it is no longer possible to maintain appropriate redox balance. Nuclear factor-E2-related factor 2 (Nrf2), a transcription factor with a high sensitivity to oxidative stress, binds to antioxidant response elements (AREs) in the