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Rakefet Pando Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

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Majdi Masarwi Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

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Biana Shtaif Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

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Anna Idelevich Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

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Efrat Monsonego-Ornan Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

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Ron Shahar Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

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Moshe Phillip Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

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Galia Gat-Yablonski Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Robert H. Smith Faculty of Agriculture, Faculty of Agricultural, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva, Israel

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to directly stimulate GH secretion ( Carro et al . 1997 , Jin et al . 1999 , Goldstone et al . 2002 , Accorsi et al . 2007 ) and significantly improve structural properties and elongation rate of bones in an IUGR model ( Bar-El Dadon et al

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Jacqueline M Wallace Rowett Institute, University of Aberdeen, Aberdeen, UK

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Wallace JM 2011 Influence of maternal dietary intake, intrauterine growth restriction (IUGR), and estrogen replacement on placental development and vascularity . Biology of Reproduction 85 ( Supplement 1 ) 801 . ( https://doi.org/10

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J A Tamblyn College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health

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M Hewison College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health

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C L Wagner College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health

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J N Bulmer College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health

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M D Kilby College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health

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intrauterine growth restriction (IUGR). Another subtype of NK cells that accumulate with decidua are the CD1d-reactive natural killer T (NKT) cells, which have an invariant T cell receptor rearrangement ( Boyson et al . 2008 ). Murine data suggest that NKT

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S F Ahmed
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C Farquharson Developmental Endocrinology Research Group, Bone Biology Group, Division of Developmental Medicine, Department of Child Health, Royal Hospital For Sick Children, University of Glasgow, Yorkhill, Glasgow G3 8SJ, UK

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. Journal of Bone and Mineral Research 9 1365 – 1370 doi:10.1002/jbmr.5650090907 . Klammt J Pfäffle R Werner H Kiess W 2008 IGF signaling defects as causes of growth failure and IUGR . Trends in Endocrinology and Metabolism 19 197 – 205

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Seokwon Jo Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Emilyn U Alejandro Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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insulin processing . Nature Communications 8 16014 . ( https://doi.org/10.1038/ncomms16014 ) Boehmer BH Limesand SW & Rozance PJ 2017 The impact of IUGR on pancreatic islet development and beta-cell function . Journal of Endocrinology 235 R63

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Nicole Draper Endocrinology, Division of Medical Sciences, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Paul M Stewart Endocrinology, Division of Medical Sciences, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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diabetes insipidus. Other renal abnormalities including renal cysts and nephrocalcinosis have been observed ( Milford 1995 , Moudgil 2000 ). Other clinical features include intra-uterine growth restriction (IUGR), short stature, thirst, polyuria and post

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