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Young Hoon Son Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Seok-Jin Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Ki-Baek Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Jin-Haeng Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Eui Man Jeong Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea
Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Sun Gun Chung Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Sang-Chul Park Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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In-Gyu Kim Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea
Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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://www.cbil.upenn.edu/cgibin , http://alggen.lsi.upc.es/cgibin/promo_v3 , and http://www.gene-regulation.com/cgi-bin . Transfection and luciferase assays C2C12 cells (2×10 4 ) were seeded into a 12-well plate and cultured for 24 h. The cells were then transfected with reporter

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Masahiro Ogawa Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 5998531, Japan

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Tomoya Kitakaze Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 5998531, Japan

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Naoki Harada Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 5998531, Japan

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Ryoichi Yamaji Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 5998531, Japan

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ERβ competitively bind to the same EREs or specifically bind to different EREs, they do not function redundantly in gene regulation. The two ER isoforms are expressed in the skeletal muscle ( Wiik et al . 2009 ) and seem to play different biological

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Misaki Kojima
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Masashi Sekimoto Animal Genome Research Unit, Department of Molecular Toxicology and Global COE Program, Division of Animal Sciences, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan

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Masakuni Degawa Animal Genome Research Unit, Department of Molecular Toxicology and Global COE Program, Division of Animal Sciences, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan

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lecture . Cancer Research 42 4875 – 4917 . Corchero J Pimprale S Kimura S Gonzalez FJ 2001 Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation . Pharmacogenetics 11 1 – 6 doi:10

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Bohan Wang Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

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I Stuart Wood Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

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Paul Trayhurn Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

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characterised by adipose tissue hypoxia and cytotoxic T-cell infiltration . International Journal of Obesity 32 451 – 463 . Rocha S 2007 Gene regulation under low oxygen: holding your breath for transcription . Trends in Biochemical Sciences 32 389 – 397

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J E Sánchez-Criado
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J Martín de las Mulas
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C Bellido
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R Aguilar
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J C Garrido-Gracia
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selective estrogen receptor modulators. Nature Medicine 6 960 –962. Mitchner NZ , Garlick C & Ben-Jonathan N 1998 Cellular distribution and gene regulation of estrogen receptors α and β in the rat pituitary gland

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Motoi Sohmiya Department of Endocrinology, Metabolism and Hematological Oncology, Shimane University School of Medicine, Izumo 693-8501, Japan

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Yuzuru Kato Department of Endocrinology, Metabolism and Hematological Oncology, Shimane University School of Medicine, Izumo 693-8501, Japan

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Journal of Physiology Cell Physiology 270 C1485 –C1492. Goldberg MA , Imagawa S, Dunning PS & Bunn HF 1989 Oxygen sensing and erythropoietin gene regulation. Contribution to Nephrology 70 39 –56

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Marnix Gorissen Department of Organismal Animal Physiology, The Clayton Foundation Laboratories for Peptide Biology, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ Nijmegen, The Netherlands

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Erik de Vrieze Department of Organismal Animal Physiology, The Clayton Foundation Laboratories for Peptide Biology, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ Nijmegen, The Netherlands

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Gert Flik Department of Organismal Animal Physiology, The Clayton Foundation Laboratories for Peptide Biology, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ Nijmegen, The Netherlands

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Mark O Huising Department of Organismal Animal Physiology, The Clayton Foundation Laboratories for Peptide Biology, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ Nijmegen, The Netherlands
Department of Organismal Animal Physiology, The Clayton Foundation Laboratories for Peptide Biology, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ Nijmegen, The Netherlands

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A Quelle FW Ihle JN 1995 Distribution of the mammalian Stat gene family in mouse chromosomes . Genomics 29 225 – 228 doi:10.1006/geno.1995.1235 . Darnell JE Jr 1997 STATs and gene regulation . Science 277 1630 – 1635 doi:10

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George Schlossmacher Endocrinology and Diabetes, Faculty of Medical and Human Sciences, Faculty of Life Sciences

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Adam Stevens Endocrinology and Diabetes, Faculty of Medical and Human Sciences, Faculty of Life Sciences

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Anne White Endocrinology and Diabetes, Faculty of Medical and Human Sciences, Faculty of Life Sciences
Endocrinology and Diabetes, Faculty of Medical and Human Sciences, Faculty of Life Sciences

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.1074/jbc.M602290200 . Thompson EB Nazareth LV Thulasi R Ashraf J Harbour D Johnson BH 1992 Glucocorticoids in malignant lymphoid cells: gene regulation and the minimum receptor fragment for lysis . Journal of Steroid Biochemistry and

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L A Santiago
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D A Santiago
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L C Faustino
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A Cordeiro
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P C Lisboa Instituto de Biofísica Carlos Chagas Filho, Departamento de Ciências Fisiológicas, Department of Pediatrics and Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil

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F E Wondisford Instituto de Biofísica Carlos Chagas Filho, Departamento de Ciências Fisiológicas, Department of Pediatrics and Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil

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C C Pazos-Moura
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T M Ortiga-Carvalho
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binding is required for both positive and negative gene regulation . Journal of Biological Chemistry 278 732 – 738 . doi:10.1074/jbc.M207264200 . Souza LL Nunes MO Paula GSM Cordeiro A Penha-Pinto V Neto JFN Oliveira KJ Tavares do Carmo

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Jin Yu Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Yuhuan Liu Department of Gynecology and Obstetrics, Changhai Hospital, Naval Medical University, Shanghai, China

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Danying Zhang Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Dongxia Zhai Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Linyi Song Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Zailong Cai Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai, China

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Chaoqin Yu Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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sequence from −507 to −325 bp was analyzed using the AliBaba2.1 software ( http://www.gene-regulation.com/pub/programs/alibaba2/index.html ), and the potential transcriptional regulatory elements, including C/EBPalp, Oct1, HNF1, NF1, GATA1, NF-EM5 and GCN4

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