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Paul W Caton Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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Nanda K Nayuni Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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Noorafza Q Khan Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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Elizabeth G Wood Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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Roger Corder Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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coactivation fatty acid genes ( Lin et al . 2005 , Nagai et al . 2009 ). Furthermore, previous studies have reported that SIRT1 can deacetylate PGC1β in skeletal muscle, inducing the expression of PGC1β gene targets. We provide evidence that a similar

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0190
Volume/Issue:
Volume 208: Issue 3
Free access
Chad Osterlund Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Robert L Spencer Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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gene targeting . Journal of Steroid Biochemistry and Molecular Biology 65 111 – 115 doi:10.1016/S0960-0760(97)00181-7 . Rudy J 2008 Is there a baby in the bathwater? Maybe: some methodological issues for the de novo protein synthesis

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0413
Volume/Issue:
Volume 208: Issue 3
Free access
J Patel School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Brisbane, Queensland 4029, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Brisbane, Queensland 4029, Australia

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K A Landers School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Brisbane, Queensland 4029, Australia

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R H Mortimer School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Brisbane, Queensland 4029, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Brisbane, Queensland 4029, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Brisbane, Queensland 4029, Australia

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K Richard School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Brisbane, Queensland 4029, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, Brisbane, Queensland 4029, Australia

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2006 ). It is also interesting to note that both C/EBP and AP-1 are up-regulated under hypoxic conditions and closely interact with HIF-1α, leading to the transcription of specific gene targets ( Cummins & Taylor 2005 , Janardhan 2008 ). In this study

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0348
Volume/Issue:
Volume 212: Issue 2
Free access
Mohan Singh Research Group in Molecular Oncology and Endocrinology, Department of Chemistry-Biology, University of Quebec, Trois-Rivieres, 3351, Boulevard Des Forges, CP 500, Trois-Rivieres, Quebec G8Y 5H7, Canada

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Parvesh Chaudhry Research Group in Molecular Oncology and Endocrinology, Department of Chemistry-Biology, University of Quebec, Trois-Rivieres, 3351, Boulevard Des Forges, CP 500, Trois-Rivieres, Quebec G8Y 5H7, Canada

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Eric Asselin Research Group in Molecular Oncology and Endocrinology, Department of Chemistry-Biology, University of Quebec, Trois-Rivieres, 3351, Boulevard Des Forges, CP 500, Trois-Rivieres, Quebec G8Y 5H7, Canada

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usually start in mouse models and other species. The prerequisite in this direction is to describe an expression pattern of a molecule followed by more mechanistic approaches such as gene targeting to correct the abnormality. Previous studies have

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0461
Volume/Issue:
Volume 210: Issue 1
Free access
Irving Salinas Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Physiology, Michigan State University, East Lansing, Michigan, USA

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Niharika Sinha Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Animal Sciences, Michigan State University, East Lansing, Michigan, USA

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Aritro Sen Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Animal Sciences, Michigan State University, East Lansing, Michigan, USA

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miR-429, miR-141-3p , and miR-126-3p promoters result in lower expression of these miRNAs that is correlated with upregulation of the genes targeted by these miRNAs, namely, XIAP (X-linked inhibitor of apoptosis protein), BRD3 (Bromodomain

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0578
Volume/Issue:
Volume 249: Issue 3
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Elizabeth K Fletcher Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
Tufts Medical Center, Boston, Massachusetts, USA

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Monica Kanki Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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James Morgan Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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David W Ray NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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Lea M Delbridge Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia

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Peter J Fuller Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Colin D Clyne Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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Morag J Young Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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data have important implications for physiological vs pathological regulation of circadian gene targets where fluctuations between ligand availability, receptor levels and thus MR and GR homodimers or MR/GR heterodimers contribute to the net regulatory

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0584
Volume/Issue:
Volume 241: Issue 1
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Ulla Simanainen
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Yan Ru (Ellen) Gao
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Reena Desai
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Mark Jimenez
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Jennifer Spaliviero
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Janet R Keast ANZAC Research Institute, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales 2139, Australia

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David J Handelsman
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Acta 409 78 – 84 . ( doi:10.1016/j.cca.2009.09.003 ) Heuckeroth RO Enomoto H Grider JR Golden JP Hanke JA Jackman A Molliver DC Bardgett ME Snider WD Johnson EM Jr 1999 Gene targeting reveals a critical role for

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0056
Volume/Issue:
Volume 218: Issue 2
Free access
Masaki Nagaya Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA

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Hitoshi Katsuta Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA

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Hideaki Kaneto Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA

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Susan Bonner-Weir Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA

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Gordon C Weir Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
Research Division, Department of Medicine, Department of Internal Medicine and Therapeutics, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA

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transcription and for the terminal differentiation of islet cells ( Chae et al . 2004 ). In NeuroD gene targeting experiments, the combination of NeuroD and betacellulin selectively induced islet related genes in the liver ( Kojima et al . 2003 ). PDX-1/VP16

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0482
Volume/Issue:
Volume 201: Issue 1
Free access
Jacob C Garza Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Chung Sub Kim Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Jing Liu Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Wei Zhang Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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Xin-Yun Lu Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA

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important question that remains to be further addressed is what neuroanatomical and neurochemical substrates convey MC4R signaling in the control of energy homeostasis. Previous studies using the gene targeting strategy in MC4R-null mice have narrowed down

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0009
Volume/Issue:
Volume 197: Issue 3
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Cristina Aresté
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M Jesús Melià
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Joan Isern
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José Luis Tovar
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Anna Meseguer
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Biophysica Acta 1346 231 –236. Walsh V , Somody L, Farrell A, Zhang B, Brown J, Pritchard C, Vincent M & Samani NJ 2003 Analysis of the Role of the SA gene in blood pressure regulation by gene targeting. Hypertension 41

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05649
Volume/Issue:
Volume 183: Issue 1
Free access