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Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

Mohammed Bensellam

Mohammed Bensellam Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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Jean-Christophe Jonas

Jean-Christophe Jonas Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d’Endocrinologie, Diabète et Nutrition, Brussels, Belgium

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D Ross Laybutt

D Ross Laybutt Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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catalyses the oxidation of retinal to retinol using NAD + . It is also involved in other metabolic processes including amino acid metabolism and the metabolism of lipid peroxidation products ( Duan et al . 2016 ). Therefore, its upregulation in the islets