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Timothy J Cole Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia

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Morag J Young Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
Department of Molecular and Translational Research, Monash University, Melbourne, Victoria, Australia

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No DOC/salt cardiac fibrosis, no macrophage recruitment Rickard et al . (2014) VE-Cad-Cre Obesity-induced dysfunction blunted inflammation Schafer et al . (2013) , Jia et al . (2015) Cardiomyocyte MLC2a-Cre Improved cardiac

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Ana Patrícia Mateus Comparative Molecular and Integrative Biology, Centro de Ciências do Mar, Universidade do Algarve, Faro, Portugal
Escola Superior de Saúde, Universidade do Algarve, Faro, Portugal

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Rita A Costa Comparative Molecular and Integrative Biology, Centro de Ciências do Mar, Universidade do Algarve, Faro, Portugal

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João C R Cardoso Comparative Molecular and Integrative Biology, Centro de Ciências do Mar, Universidade do Algarve, Faro, Portugal

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Karl B Andree IRTA-SCR, Unitat de Cultius Aqüicoles, Sant Carles de la Ràpita, Spain

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Alicia Estévez IRTA-SCR, Unitat de Cultius Aqüicoles, Sant Carles de la Ràpita, Spain

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Enric Gisbert IRTA-SCR, Unitat de Cultius Aqüicoles, Sant Carles de la Ràpita, Spain

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Deborah M Power Comparative Molecular and Integrative Biology, Centro de Ciências do Mar, Universidade do Algarve, Faro, Portugal

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modifications in the number, size and pigment content of aggregates of macrophages, the melanomacrophage centers (MMCs) of the piscine innate immune system ( Fournie et al. 2001 , Agius & Roberts 2003 , De Vico et al. 2008 ), and this is the predominant

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Wang Xiao Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China

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Fei Beibei Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China

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Shen Guangsi Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China

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Jiang Yu Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China

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Zhang Wen Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China

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Huang Xi Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China

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Xu Youjia Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China

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work, we established a male mouse model to observe the influence of iron on oxidative stress and bone resorption in vivo ( Jia et al . 2012 ). In addition, we treated a murine macrophage cell line, RAW264.7 with ferric ions to test their activity

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Azusa Sameshima Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Tsutomu Wada Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Tetsuo Ito Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Ayaka Kashimura Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Kanae Sawakawa Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Rika Yonezawa Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Hiroshi Tsuneki Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Yoko Ishii Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Masakiyo Sasahara Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Shigeru Saito Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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Toshiyasu Sasaoka Departments of Obstetrics and Gynecology, Clinical Pharmacology, Pathology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

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shown to attenuate obesity-induced chronic inflammation in adipose tissue by repressing the inflammatory responses of macrophages ( Ribas et al . 2011 ). Previous studies reported that estrogen acted on the CNS, especially on the hypothalamus

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Guillermo García-Eguren Group of Endocrine Disorders, IDIBAPS, Barcelona, Spain

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Oriol Giró Group of Endocrine Disorders, IDIBAPS, Barcelona, Spain

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María del Mar Romero Department of Biochemistry and Molecular Biomedicine, Section of Nutrition, Faculty of Biology, University of Barcelona, Barcelona, Spain
Institute of Biomedicine, University of Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Obesidad y Nutrición (CIBEROBN), Carlos III Health Institute, Madrid, Spain

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Mar Grasa Department of Biochemistry and Molecular Biomedicine, Section of Nutrition, Faculty of Biology, University of Barcelona, Barcelona, Spain
Institute of Biomedicine, University of Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Obesidad y Nutrición (CIBEROBN), Carlos III Health Institute, Madrid, Spain

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Felicia A Hanzu Group of Endocrine Disorders, IDIBAPS, Barcelona, Spain
Department of Endocrinology and Nutrition, Hospital Clinic of Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Carlos III Health Institute, Madrid, Spain
Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain

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macrophages in white adipose tissue Sections of 5 µm from the paraffin-embedded epididymal adipose tissue were deparaffinized and rehydrated in water. A pre-treatment using proteinase K was performed, and slides were blocked in 5% donkey serum for 1 h at

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Karen Francis
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B Mary Lewis
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Peter N Monk Centre for Endocrine and Diabetes Sciences, Academic Neurology Unit, Cardiff University, Cardiff, CF14 4XN, UK

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Jack Ham
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stimulated the activation of signalling molecules ERK/MAPK and AKT. On the other hand, C5a and C5adR both inhibited the secretion of the inflammatory molecule, macrophage migration inhibitory factor (MIF) yet stimulated the secretion of ACTH. These data

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Ronald J van der Sluis
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Tim van den Aardweg
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Anne Q Reuwer Division of Biopharmaceutics, Laboratory for Microbiology and Infection Control, Department Endocrinology, Inserm, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333CC Leiden, The Netherlands

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Marcel T Twickler Division of Biopharmaceutics, Laboratory for Microbiology and Infection Control, Department Endocrinology, Inserm, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333CC Leiden, The Netherlands

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Florence Boutillon Division of Biopharmaceutics, Laboratory for Microbiology and Infection Control, Department Endocrinology, Inserm, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333CC Leiden, The Netherlands

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Miranda Van Eck
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Vincent Goffin Division of Biopharmaceutics, Laboratory for Microbiology and Infection Control, Department Endocrinology, Inserm, Gorlaeus Laboratories, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333CC Leiden, The Netherlands

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Menno Hoekstra
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aortic root, starting at the appearance of the tricuspid valves. Collagen content of the lesions was determined after Masson's Trichrome staining (Sigma Diagnostics). Sections were stained immunohistochemically for the presence of macrophages using a MOMA

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Antonios Chatzigeorgiou Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece
Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece

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Eleni Kandaraki Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece
Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece

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Christina Piperi Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece

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Sarantis Livadas Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece

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Athanasios G Papavassiliou Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece

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Michael Koutsilieris Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece

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Apostolos Papalois Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece

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Evanthia Diamanti-Kandarakis Department of Experimental Physiology, Department of Internal Medicine III and Institute of Physiology, Department of Biological Chemistry, Endocrine Unit, Experimental Research Centre, University of Athens Medical School, Athens, Greece

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and SR-BI ( Miyazaki et al . 2002 ). Macrophage SR-A, the product of the MSR1 gene, is a multifunctional, multiligand pattern recognition receptor with roles in innate immunity, apoptotic cell clearance and age-related degenerative pathologies, such

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Aran Son Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea

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Namju Kang Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea
BK21 PLUS Project, Yonsei University College of Dentistry, Seoul, Korea

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Sue Young Oh Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea

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Ki Woo Kim Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea

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Shmuel Muallem Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA

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Yu-Mi Yang Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea

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Dong Min Shin Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea
BK21 PLUS Project, Yonsei University College of Dentistry, Seoul, Korea

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. Examples are autoimmune arthritis, osteoporosis, periodontitis, osteopetrosis and bone tumors ( Takayanagi 2007 , Zaidi 2007 ). Multinucleated mature osteoclasts originate from bone marrow-derived monocytes/macrophages (BMMs) through two essential factors

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Alena Nareika Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine

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Yeong-Bin Im Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine

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Bryan A Game Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine

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Elizabeth H Slate Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine

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John J Sanders Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine

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Steven D London Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine

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Maria F Lopes-Virella Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine
Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine

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Yan Huang Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine
Ralph H Johnson Veterans Affairs Medical Center, Division of Endocrinology, Department of Biostatistics, College of Dental Medicine

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, studies have shown that macrophages isolated from CD14 knockout mice are unable to produce TNFα, IL-1β, and interferon-inducible protein-10 in response to LPS and these mice have an early death in pneumococcal infection ( Vogel et al . 1998 ). Clearly

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