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Ann E Drummond Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia

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Peter J Fuller Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia

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Endocrinology 11 353 – 365 . Vendrell JA Magnino F Danis E Duchesne MJ Pinloche S Pons M Birnbaum D Nguyen C Theillet C Cohen PA 2004 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0379
Volume/Issue:
Volume 205: Issue 1
Free access
Emma Castrique Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Marta Fernandez-Fuente Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Paul Le Tissier Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Andy Herman Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Andy Levy Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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: rapid reversion of acidophilic cell types to pregestational proportions after weaning . Endocrinology 129 1215 – 1220 . Schmidt-Suppiran M Rajewsky K 2007 Vagaries of conditional gene targeting . Nature Immunology 8 665 – 668 . Srinivas

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0414
Volume/Issue:
Volume 205: Issue 1
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Sophie Fouchécourt INSERM U 418; INRA UMR 1245; Université Claude-Bernard Lyon 1, 29 rue Sœur Bouvier, 69322 Lyon Cedex 05, France
Faculté de Médécine, Centre Commun de Cytométrie en Flux, Université Jean Monnet, 42023 St Etienne, France

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Murielle Godet INSERM U 418; INRA UMR 1245; Université Claude-Bernard Lyon 1, 29 rue Sœur Bouvier, 69322 Lyon Cedex 05, France
Faculté de Médécine, Centre Commun de Cytométrie en Flux, Université Jean Monnet, 42023 St Etienne, France

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Odile Sabido INSERM U 418; INRA UMR 1245; Université Claude-Bernard Lyon 1, 29 rue Sœur Bouvier, 69322 Lyon Cedex 05, France
Faculté de Médécine, Centre Commun de Cytométrie en Flux, Université Jean Monnet, 42023 St Etienne, France

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Philippe Durand INSERM U 418; INRA UMR 1245; Université Claude-Bernard Lyon 1, 29 rue Sœur Bouvier, 69322 Lyon Cedex 05, France
Faculté de Médécine, Centre Commun de Cytométrie en Flux, Université Jean Monnet, 42023 St Etienne, France

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-central nervous system and peripheral organs including the kidneys, lungs, blood, and testes ( Suter-Crazzolara & Unsicker 1994 , Trupp et al. 1995 , Suvanto et al. 1996 ). Although fertile, gene-targeted mice with one GDNF-null allele show depletion

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06699
Volume/Issue:
Volume 190: Issue 1
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Kyuyong Han Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
Laboratory of Reproductive Biology and Infertility, Cheil General Hospital, Women’s Healthcare Center, Seoul 100-380, Korea
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101-1709, USA

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Haengseok Song Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
Laboratory of Reproductive Biology and Infertility, Cheil General Hospital, Women’s Healthcare Center, Seoul 100-380, Korea
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101-1709, USA

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Irene Moon Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
Laboratory of Reproductive Biology and Infertility, Cheil General Hospital, Women’s Healthcare Center, Seoul 100-380, Korea
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101-1709, USA

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Robert Augustin Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
Laboratory of Reproductive Biology and Infertility, Cheil General Hospital, Women’s Healthcare Center, Seoul 100-380, Korea
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101-1709, USA

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Kelle Moley Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
Laboratory of Reproductive Biology and Infertility, Cheil General Hospital, Women’s Healthcare Center, Seoul 100-380, Korea
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101-1709, USA

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Melissa Rogers Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
Laboratory of Reproductive Biology and Infertility, Cheil General Hospital, Women’s Healthcare Center, Seoul 100-380, Korea
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101-1709, USA

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Hyunjung Lim Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
Laboratory of Reproductive Biology and Infertility, Cheil General Hospital, Women’s Healthcare Center, Seoul 100-380, Korea
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101-1709, USA

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spermatogenesis including spermatogonia differentiation and spermiation ( Kastner et al. 1996 , Cupp et al. 1999 ). Among RA receptors, roles for RARα and RXRβ in testis functions have been demonstrated in gene-targeted mouse models. RXRβ mutant mice have

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0115
Volume/Issue:
Volume 192: Issue 3
Free access
Yun-Ju Chen Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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Pei-Wen Hsiao Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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Ming-Ting Lee Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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J Ian Mason Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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Ferng-Chun Ke Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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Jiuan-Jiuan Hwang Institute of Physiology, School of Medicine, National Yang-Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
Agricultural Biotechnology Research Center,
Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China
Division of Reproductive and Developmental Science, Queen’s Medical Research Institute, Edinburgh University, Edinburgh EH16 4TJ, UK
Institute of Molecular and Cellular Biology, School of Life Science, National Taiwan University, Taipei 106, Taiwan, ROC

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/Akt activation. Journal of Biological Chemistry 278 22374 –22378. Vanhaesebroeck B , Ali K, Bilancio A, Geering B & Foukas LC 2005 Signalling by PI3K isoforms: insights from gene-target mice. Trends in Biochemical Sciences 30

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0076
Volume/Issue:
Volume 192: Issue 2
Free access
Oliver Treeck Department of Obstetrics and Gynecology, Klinik für Frauenheilkunde und Geburtshilfe, University of Regensburg, Landshuter Strasse 65, 93053 Regensburg, Germany

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Georg Pfeiler Department of Obstetrics and Gynecology, Klinik für Frauenheilkunde und Geburtshilfe, University of Regensburg, Landshuter Strasse 65, 93053 Regensburg, Germany

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Diana Mitter Department of Obstetrics and Gynecology, Klinik für Frauenheilkunde und Geburtshilfe, University of Regensburg, Landshuter Strasse 65, 93053 Regensburg, Germany

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Claus Lattrich Department of Obstetrics and Gynecology, Klinik für Frauenheilkunde und Geburtshilfe, University of Regensburg, Landshuter Strasse 65, 93053 Regensburg, Germany

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Gerhard Piendl Department of Obstetrics and Gynecology, Klinik für Frauenheilkunde und Geburtshilfe, University of Regensburg, Landshuter Strasse 65, 93053 Regensburg, Germany

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Olaf Ortmann Department of Obstetrics and Gynecology, Klinik für Frauenheilkunde und Geburtshilfe, University of Regensburg, Landshuter Strasse 65, 93053 Regensburg, Germany

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. Vendrell JA , Magnino F, Danis E, Duchesne MJ, Pinloche S, Pons M, Birnbaum D, Nguyen C, Theillet C & Cohen PA 2004 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0087
Volume/Issue:
Volume 193: Issue 3
Free access
Natali Anne Henderson Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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Gerard M Cooke Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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Bernard Robaire Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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stock that was used in all PCR experiments. For each analysis, six serial dilutions of the standard cDNA were run as a calibration curve parallel to the samples. The levels of mRNA for each gene (target and reference genes) were determined by comparing

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06862
Volume/Issue:
Volume 190: Issue 3
Free access
J L Crawford Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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B P Thomson Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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M F Beaumont Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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D C Eckery Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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4812 –4820. Thomas K & Capecchi M 1987 Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51 503 –512. Thorner MO , Vance ML, Horvath E & Kovacs K 1992

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06882
Volume/Issue:
Volume 190: Issue 2
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Judith L Turgeon Division of Endocrinology, Department of Internal Medicine, School of Medicine, University of California Davis, Davis, California 95616, USA

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Dennis W Waring Division of Endocrinology, Department of Internal Medicine, School of Medicine, University of California Davis, Davis, California 95616, USA

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B expression was examined in an inducible model of PR-A predominance in breast cancer lines. While most PR-target genes were not sensitive to the ratio change, progestin responsiveness was acquired in a subpopulation of gene targets involved in a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06923
Volume/Issue:
Volume 190: Issue 3
Free access
S Shaikh Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand

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F H Bloomfield Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand

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M K Bauer Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand

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H H Phua Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand

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R S Gilmour Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand

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J E Harding Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand

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-responsive gut growth factor. Journal of Nutrition 131 709 –712. Butler AA & LeRoith D 2001 Minireview: tissue-specific versus generalized gene targeting of the IGF1 and IGF1r genes and their roles in insulin-like growth factor

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06113
Volume/Issue:
Volume 186: Issue 1
Free access