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Marian Joëls Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands
University of Groningen, University Medical Center, Groningen, The Netherlands

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E Ronald de Kloet Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

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maintain homeostasis and to promote behavioural adaptation: ‘ The MR:GR balance hypothesis predicts that upon imbalance of these receptor functions threats to homeostasis are less well communicated and coordinated among the various glucocorticoid targets

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Sophie M T Wehrens Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

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Shelagh M Hampton Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

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Rebecca E Finn Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

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Debra J Skene Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

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( Knutsson et al . 1986 , Schernhammer et al . 2001 ). Long-term shift work may lead to either adaptation or sensitisation to the effects of sleep deprivation. This suggests that non-shift workers and experienced shift workers may respond differently when

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Shannon M Gifford Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin – Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Fu-Xian Yi Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin – Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Ian M Bird Perinatal Research Laboratories, Department of Obstetrics and Gynecology, University of Wisconsin – Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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adaptation at the level of Ca 2+ signaling in UAEC. In addition, we study the ability of the cells to allow influx via capacitative entry (CCE) independent of the agonist. We find that it is not a change in receptor subtype or coupling but rather the greater

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Marian Joëls Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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adaptation. This hormonal response involves several well-described steps. Directly after stress, circuits involving the brainstem lead to activation of the sympathetic nervous system, causing enhanced release of adrenaline from the adrenal medulla ( Wong et

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M G Gnanalingham Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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A Mostyn Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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J Wang Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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R Webb Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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D H Keisler Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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N Raver Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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M C Alves-Guerra Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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C Pecqueur Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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B Miroux Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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T Stephenson Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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M E Symonds Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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after birth and then rapidly decreases over the first month of life ( Gnanalingham et al. 2005 ). This developmental pattern of expression is similar to that described for UCP1 in ovine BAT, suggesting UCP2 has a critical role in metabolic adaptation

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Shona Wood Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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Andrew Loudon Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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mechanisms allowing organisms to predict key environmental changes. Mammals exhibit a remarkably wide spectrum of seasonal physiological adaptations, which includes annual cycles of growth, metabolism, thermogenesis, fattening and weight loss, hibernation

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Joachim M Weitzel Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Albrecht Institute of Microbiology, Ernst-Moritz-Arndt-University, Greifswald, Germany

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Rupert Bruckmaier Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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Marion Schmicke Clinic for Cattle, Endocrinology Laboratory, University of Veterinary Medicine Hannover, Hannover, Germany

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Armin Tuchscherer Institute of Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Franziska Koch Institute of Nutritional Physiology ‘Oskar Kellner’, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Björn Kuhla Institute of Nutritional Physiology ‘Oskar Kellner’, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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3 concentration in HSpp animals is associated by reduction of the stress defense enzymes TST, PRDX3, PRDX6, ETHE1 and also CAT, strongly suggesting the involvement of T 3 - and THRA-mediated signaling in this adaptation process. Downregulation of

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Nathanael J Yates School of Human Sciences, The University of Western Australia, Perth, Australia

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Dijana Tesic School of Human Sciences, The University of Western Australia, Perth, Australia

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Kirk W Feindel Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, Australia

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Jeremy T Smith School of Human Sciences, The University of Western Australia, Perth, Australia

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Michael W Clarke Metabolomics Australia, Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, Australia

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Celeste Wale School of Human Sciences, The University of Western Australia, Perth, Australia

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Rachael C Crew School of Human Sciences, The University of Western Australia, Perth, Australia

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Michaela D Wharfe School of Human Sciences, The University of Western Australia, Perth, Australia

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Andrew J O Whitehouse Telethon Kids Institute, The University of Western Australia, Perth, Australia

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Caitlin S Wyrwoll School of Human Sciences, The University of Western Australia, Perth, Australia

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Wyrwoll CS Smith JT Yap C Clarke MW Waddell BJ 2016 Pregnancy-induced adaptations of the central circadian clock and maternal glucocorticoids . Journal of Endocrinology 228 135 – 147 . ( https://doi.org/10

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Marina Komrakova
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Stephan Sehmisch
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Mohammad Tezval
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Ulrich Schmelz Department of Trauma Surgery and Reconstructive Surgery, Subdivision of General Hygiene and Environmental Health, Department of Organic and Biomolecular Chemistry, University of Goettingen, Robert-Koch Street 40, 37075 Goettingen, Germany

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Holm Frauendorf Department of Trauma Surgery and Reconstructive Surgery, Subdivision of General Hygiene and Environmental Health, Department of Organic and Biomolecular Chemistry, University of Goettingen, Robert-Koch Street 40, 37075 Goettingen, Germany

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Thomas Grueger
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Thomas Wessling
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Carolin Klein
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Miriam Birth
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Klaus M Stuermer
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Ewa K Stuermer
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cortical and cancellous bone parameters observed in the course of treatments (5 vs 10 weeks) not only in treated groups but also in untreated SF group may be explained by the adaptation mechanisms to the potentially negative effect of osteoporosis

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S E Chadio Laboratory of Anatomy and Physiology of Domestic Animals,
Laboratory of Animal Nutrition,
Laboratory of Animal Breeding, Department of Animal Science, Agricultural University of Athens, 75, Iera odos, 11855 Athens, Greece

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B Kotsampasi Laboratory of Anatomy and Physiology of Domestic Animals,
Laboratory of Animal Nutrition,
Laboratory of Animal Breeding, Department of Animal Science, Agricultural University of Athens, 75, Iera odos, 11855 Athens, Greece

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G Papadomichelakis Laboratory of Anatomy and Physiology of Domestic Animals,
Laboratory of Animal Nutrition,
Laboratory of Animal Breeding, Department of Animal Science, Agricultural University of Athens, 75, Iera odos, 11855 Athens, Greece

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S Deligeorgis Laboratory of Anatomy and Physiology of Domestic Animals,
Laboratory of Animal Nutrition,
Laboratory of Animal Breeding, Department of Animal Science, Agricultural University of Athens, 75, Iera odos, 11855 Athens, Greece

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D Kalogiannis Laboratory of Anatomy and Physiology of Domestic Animals,
Laboratory of Animal Nutrition,
Laboratory of Animal Breeding, Department of Animal Science, Agricultural University of Athens, 75, Iera odos, 11855 Athens, Greece

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I Menegatos Laboratory of Anatomy and Physiology of Domestic Animals,
Laboratory of Animal Nutrition,
Laboratory of Animal Breeding, Department of Animal Science, Agricultural University of Athens, 75, Iera odos, 11855 Athens, Greece

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G Zervas Laboratory of Anatomy and Physiology of Domestic Animals,
Laboratory of Animal Nutrition,
Laboratory of Animal Breeding, Department of Animal Science, Agricultural University of Athens, 75, Iera odos, 11855 Athens, Greece

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disease in adult life. Lancet 341 938 –941. Bispham J , Gopalakrishnan GS, Dandrea J, Wilson V, Budge H, Keisler DH, Broughton Pipkin F, Stephenson T & Symonds ME 2003 Maternal endocrine adaptation throughout pregnancy to

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