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Simon J Dunmore
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James E P Brown Diabetes and Metabolic Disease Research Group, Aston Research Centre for Healthy Ageing, Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton WV1 1LY, UK

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Introduction Pancreatic β-cell failure, alongside insulin resistance, can be considered as one of the two key events that leads to the development of type 2 diabetes ( Leahy et al . 2010 ). In the early stages of the disease, insulin resistance is

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-12-0278
Volume/Issue:
Volume 216: Issue 1
Free access
Liselotte Fransson Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden

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Stephanie Franzén Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden
Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden

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Victoria Rosengren Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden

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Petra Wolbert Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden

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Åke Sjöholm Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden
Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden

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Henrik Ortsäter Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden

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-treated mice. Ectopic fat accumulation is a condition often referred to as having a substantial negative effect on insulin sensitivity, which also is a key factor of type 2 diabetes and the metabolic syndrome ( Hagberg et al . 2012 , Tchernof & Despres 2013

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0189
Volume/Issue:
Volume 219: Issue 3
Free access
Christina Antza Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Georgios Kostopoulos Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece

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Samiul Mostafa Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Krishnarajah Nirantharakumar Institute of Applied Health Research, University of Birmingham, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Abd Tahrani Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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) ( https://apps.who.int/gho/data/view.main.REGION2480A?lang=en Accessed (September) (2021)). Considering the health and economic consequences associated with obesity (type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), cancer, mortality), there

Article Type:
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Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JOE-21-0155
Volume/Issue:
Volume 252: Issue 2
Open access
Nele Friedrich Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand-Sauerbruch-Strasse, D-17475 Greifswald, Germany

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Introduction Diabetes mellitus, particularly type 2 diabetes (T2DM), represents one of the most significant global health problems because it is associated with a large economic burden on the health systems of many countries. The World Health

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0120
Volume/Issue:
Volume 215: Issue 1
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Martin Haluzík Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

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Helena Kratochvílová Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

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Denisa Haluzíková Department of Sports Medicine, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

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Miloš Mráz Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

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Introduction Increasing prevalence of type 2 diabetes mellitus (T2DM) worldwide and its close interconnection with other pathologies such as obesity, arterial hypertension, dyslipidemia and many others commonly referred to as metabolic or

Article Type:
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DOI:
https://doi.org/10.1530/JOE-17-0438
Volume/Issue:
Volume 237: Issue 1
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Chidum Ezenwaka Unit of Pathology and Microbiology, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany

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Risha Kalloo Unit of Pathology and Microbiology, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany

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Mathias Uhlig Unit of Pathology and Microbiology, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany

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Robert Schwenk Unit of Pathology and Microbiology, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany

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Juergen Eckel Unit of Pathology and Microbiology, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany

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Introduction Several research studies in different populations have confirmed that offspring and first-degree relatives of patients with type 2 diabetes mellitus are at increased risk of developing the disorder in later life

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06117
Volume/Issue:
Volume 185: Issue 3
Free access
Tatiana Dorfman Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel

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Yulia Pollak Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel

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Rima Sohotnik Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel

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Arnold G Coran Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel

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Jacob Bejar Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel

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Igor Sukhotnik Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel

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lowering blood glucose levels. In recent clinical trials, enhanced proliferation, accompanied by increased aerobic glycolysis, was detected in colorectal epithelium of patients with diabetes and was correlated with β-catenin accumulation ( Li et al . 2014

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0725
Volume/Issue:
Volume 226: Issue 3
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Joshua A Kulas Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, USA

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Kendra L Puig Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, USA

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Colin K Combs Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, USA

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& Ferreira 2014 , de la Monte 2014 , Bedse et al. 2015 ). Type 2 diabetes, or insulin resistance, is reported to be a risk factor for developing dementia and evidence suggests insulin signaling dysfunction occurs in the brains of AD patients ( Talbot et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0122
Volume/Issue:
Volume 235: Issue 1
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Sergio Di Meo Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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Susanna Iossa Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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Paola Venditti Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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, consequence of the obesity is the increased risk for various illnesses, such as diabetes mellitus, gallbladder disease, osteoarthritis, coronary artery disease and some forms of cancer ( Vona-Davis et al . 2007 ). In the last century, the disease that is

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0186
Volume/Issue:
Volume 234: Issue 3
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Philip Newsholme School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Vinicius Cruzat School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Frank Arfuso School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Kevin Keane School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Introduction Homoeostatic regulation of fuel metabolism in the body is a tightly controlled process and dysregulation can lead to pathological conditions such as diabetes mellitus (DM), cardiovascular disease, stroke, renal disease and other

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0616
Volume/Issue:
Volume 221: Issue 3
Free access