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Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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3rd Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
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Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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2nd Internal Department, 3rd Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
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Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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Introduction Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. It is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation
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Introduction Pancreatic β-cell failure, alongside insulin resistance, can be considered as one of the two key events that leads to the development of type 2 diabetes ( Leahy et al . 2010 ). In the early stages of the disease, insulin resistance is
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Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden
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Department of Clinical Science and Education, Division of Drug Research, Center of Medical Image Science and Visualization, Department of Biochemistry and Molecular Biology, Södersjukhuset, Karolinska Institutet, SE-118 83 Stockholm, Sweden
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-treated mice. Ectopic fat accumulation is a condition often referred to as having a substantial negative effect on insulin sensitivity, which also is a key factor of type 2 diabetes and the metabolic syndrome ( Hagberg et al . 2012 , Tchernof & Despres 2013
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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) ( https://apps.who.int/gho/data/view.main.REGION2480A?lang=en Accessed (September) (2021)). Considering the health and economic consequences associated with obesity (type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), cancer, mortality), there
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Introduction Diabetes mellitus, particularly type 2 diabetes (T2DM), represents one of the most significant global health problems because it is associated with a large economic burden on the health systems of many countries. The World Health
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic
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Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic
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Department of Medical Biochemistry and Laboratory Diagnostics, General University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic
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Introduction Increasing prevalence of type 2 diabetes mellitus (T2DM) worldwide and its close interconnection with other pathologies such as obesity, arterial hypertension, dyslipidemia and many others commonly referred to as metabolic or
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany
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Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany
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Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany
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Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany
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Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Düsseldorf, Germany
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Introduction Several research studies in different populations have confirmed that offspring and first-degree relatives of patients with type 2 diabetes mellitus are at increased risk of developing the disorder in later life
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Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
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lowering blood glucose levels. In recent clinical trials, enhanced proliferation, accompanied by increased aerobic glycolysis, was detected in colorectal epithelium of patients with diabetes and was correlated with β-catenin accumulation ( Li et al . 2014
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& Ferreira 2014 , de la Monte 2014 , Bedse et al. 2015 ). Type 2 diabetes, or insulin resistance, is reported to be a risk factor for developing dementia and evidence suggests insulin signaling dysfunction occurs in the brains of AD patients ( Talbot et
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, consequence of the obesity is the increased risk for various illnesses, such as diabetes mellitus, gallbladder disease, osteoarthritis, coronary artery disease and some forms of cancer ( Vona-Davis et al . 2007 ). In the last century, the disease that is