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Chad D Osterlund Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Vanessa Thompson Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Laura Hinds Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Robert L Spencer Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, Colorado 80309, USA

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Introduction Corticotropin-releasing hormone (CRH) neurons of the hypothalamic–pituitary–adrenal (HPA) axis integrate stress-dependent changes in neural input and direct negative feedback effects of glucocorticoids ( Dallman et al . 1987

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L A Nolan Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A Levy Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Introduction Variations in physiological demands on the hypothalamo-pituitary–gonadal axis during development and throughout adulthood produce some of the most profound central neuroendocrine changes seen. At the pituitary level

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Judith L Turgeon Division of Endocrinology, Department of Internal Medicine, School of Medicine, University of California Davis, Davis, California 95616, USA

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Dennis W Waring Division of Endocrinology, Department of Internal Medicine, School of Medicine, University of California Davis, Davis, California 95616, USA

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pituitary cells, progesterone augmentation of GnRH-stimulated LH secretion can be demonstrated, but it is about half of that found for the rat and is only partially prevented by PR antagonists ( Turgeon & Waring 2001 ). Additionally in mouse gonadotropes

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Branka Šošić-Jurjević
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Branko Filipović
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Kostja Renko Department of Cytology, Institut für Experimentelle Endokrinologie, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Despot Stefan Boulevard 142, 11000 Belgrade, Serbia

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Vladimir Ajdžanović
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Milica Manojlović-Stojanoski
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Verica Milošević
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Josef Köhrle Department of Cytology, Institut für Experimentelle Endokrinologie, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Despot Stefan Boulevard 142, 11000 Belgrade, Serbia

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(DIO) enzymes. Endogenous sex steroids, both estrogen and testosterone, play an important yet poorly defined role in regulation of the hypothalamus–pituitary–thyroid (HPT) axis and TH homeostasis. Clinical evidence demonstrated that female patients have

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Evelyn Davies Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

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Selma Omer Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

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John F Morris Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

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Helen C Christian Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

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Introduction Sex differences in hypothalamo–pituitary–adrenal axis (HPA) activity are well documented and a number of studies have demonstrated that gonadal steroids act as regulators of HPA activity ( Viau & Meaney 1991 , Freeman

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Gheorghe F Y Cheng Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

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Chi-Wai Yuen Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

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Wei Ge Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

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neuroendocrine and endocrine regulation, pituitary gonadotropins are also subject to local paracrine regulation by activin ( Yam et al . 1999 a , Yuen & Ge 2004 ), similar to the situation in mammals ( Roberts et al . 1989 , Corrigan et al . 1991

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A Boelen Department of Endocrinology, Metabolism, F5-165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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J Kwakkel Department of Endocrinology, Metabolism, F5-165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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X G Vos Department of Endocrinology, Metabolism, F5-165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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W M Wiersinga Department of Endocrinology, Metabolism, F5-165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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E Fliers Department of Endocrinology, Metabolism, F5-165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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Introduction During fasting, profound changes occur in the hypothalamic part of the hypothalamic–pituitary–thyroid axis (HPT axis), i.e. increased type 2 deiodinase (D2) activity in the arcuate nucleus (ARC) ( Diano et al. 1998

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Stamatis Varsamos Adaptation Ecophysiologique et Ontogenèse, UMR 5171, GPIA, Université Montpellier II, Place Eugène Bataillon, CC092, 34095 Montpellier Cedex 05, France
IGH/UPR, CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 05, France
Department of Animal Physiology, Faculty of Science, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Benoît Xuereb Adaptation Ecophysiologique et Ontogenèse, UMR 5171, GPIA, Université Montpellier II, Place Eugène Bataillon, CC092, 34095 Montpellier Cedex 05, France
IGH/UPR, CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 05, France
Department of Animal Physiology, Faculty of Science, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Thérèse Commes Adaptation Ecophysiologique et Ontogenèse, UMR 5171, GPIA, Université Montpellier II, Place Eugène Bataillon, CC092, 34095 Montpellier Cedex 05, France
IGH/UPR, CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 05, France
Department of Animal Physiology, Faculty of Science, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Gert Flik Adaptation Ecophysiologique et Ontogenèse, UMR 5171, GPIA, Université Montpellier II, Place Eugène Bataillon, CC092, 34095 Montpellier Cedex 05, France
IGH/UPR, CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 05, France
Department of Animal Physiology, Faculty of Science, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Céline Spanings-Pierrot Adaptation Ecophysiologique et Ontogenèse, UMR 5171, GPIA, Université Montpellier II, Place Eugène Bataillon, CC092, 34095 Montpellier Cedex 05, France
IGH/UPR, CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 05, France
Department of Animal Physiology, Faculty of Science, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

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Introduction Endocrine control of osmoregulation has been studied only in a limited number of teleostean species, with an emphasis on salmonids. These studies underline the importance of pituitary hormones, such as prolactin ( Hirano

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Tamiki Hikake
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Shinji Hayashi
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Taisen Iguchi International Graduate School of Arts and Sciences, The Graduate University for Advanced Studies and Okazaki Institute for Integrative Bioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan

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Tomomi Sato
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Introduction Differentiation of anterior pituitary cells is thought to be controlled by various factors from the hypothalamus, peripheral hormones and/or growth factors ( Schwardz 2000 , Denef 2003 ). In fetal mice, hormone-producing cells except

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Christian K Tipsmark Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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Christina N Strom Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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Sean T Bailey Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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Russell J Borski Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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Introduction Among the pituitary hormones, prolactin (PRL) is the most versatile in the spectrum and number of functions it regulates. PRL modulates virtually every aspect of vertebrate physiology, including osmoregulation, growth, metabolism

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