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F E Utama Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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M J LeBaron Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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L M Neilson Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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A S Sultan Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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A F Parlow Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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K-U Wagner Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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H Rui Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E504, 3970 Reservoir Road NW, Washington, District of Columbia 20057, USA
National Hormone and Peptide Program, Harbor-UCLA Medical Center, Torrence, California 90509, USA
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198, USA

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achieved by genetic engineering such as transgenic overexpression or gene targeting. Three transgenic mouse strains have been reported to express rat prolactin under the metallothionine promoter ( Wennbo et al. 1997 a ), or the prostate-specific probasin

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06560
Volume/Issue:
Volume 188: Issue 3
Free access
J Svensson Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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M Diez Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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J Engel Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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C Wass Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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Å Tivesten Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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J-O Jansson Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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O Isaksson Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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T Archer Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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T Hökfelt Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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C Ohlsson Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Pharmacology, Göteborg University, Göteborg, Sweden
Department of Psychology, Göteborg University, Göteborg, Sweden

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Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation. PNAS 94 14054 –14059. Kuhn R , Schwenk F, Aguet M & Rajewsky K 1995 Inducible gene

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06631
Volume/Issue:
Volume 189: Issue 3
Free access
A Feraco Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy
INSERM, UMR_S 1138, Teams 1, Centre de Recherche des Cordeliers, UPMC Univ Paris 06, Université Paris Descartes, Paris, France

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A Armani Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy

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R Urbanet INSERM, UMR_S 1138, Teams 1, Centre de Recherche des Cordeliers, UPMC Univ Paris 06, Université Paris Descartes, Paris, France

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A Nguyen Dinh Cat INSERM, UMR_S 1138, Teams 1, Centre de Recherche des Cordeliers, UPMC Univ Paris 06, Université Paris Descartes, Paris, France

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V Marzolla Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy

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F Jaisser INSERM, UMR_S 1138, Teams 1, Centre de Recherche des Cordeliers, UPMC Univ Paris 06, Université Paris Descartes, Paris, France

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M Caprio Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy

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-1541 ) 20068130 10.2337/db09-1541 Lee KY Russell SJ Ussar S Boucher J Vernochet C Mori MA Smyth G Rourk M Cederquist C Rosen ED , 2013 Lessons on conditional gene targeting in mouse adipose tissue . Diabetes 62 864 – 874 . ( https://doi.org/10.2337/db

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0314
Volume/Issue:
Volume 239: Issue 2
Free access
Antonius Plagge
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Gavin Kelsey Physiological Laboratory, Laboratory of Developmental Genetics and Imprinting, Division of Pediatric Endocrinology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK

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Emily L Germain-Lee Physiological Laboratory, Laboratory of Developmental Genetics and Imprinting, Division of Pediatric Endocrinology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK

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al . 2007 ). In general, ossification symptoms are a classical AHO feature, as they can occur upon mutations of the maternal or paternal allele. Loss of paternally expressed XLα s (through gene targeting of the Gnasxl -specific exon) causes

Article Type:
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DOI:
https://doi.org/10.1677/JOE-07-0544
Volume/Issue:
Volume 196: Issue 2
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Paolo Comeglio Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Ilaria Cellai Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Tommaso Mello Gastroenterology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Sandra Filippi Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of NEUROFARBA, University of Florence, Florence, Italy

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Elena Maneschi Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Francesca Corcetto Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Chiara Corno Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Erica Sarchielli Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Annamaria Morelli Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Elena Rapizzi Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Daniele Bani Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Daniele Guasti Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Gabriella Barbara Vannelli Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Andrea Galli Gastroenterology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Luciano Adorini Intercept Pharmaceuticals, New York, New York, USA

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Mario Maggi Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy
I.N.B.B. – Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy

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Linda Vignozzi Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy
I.N.B.B. – Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy
Gynecologic Endocrinology Research Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Gene targeting in rabbits: single-step generation of knock-out rabbits by microinjection of CRISPR/Cas9 plasmids . Methods in Molecular Biology 1630 109 - 120 . 10.1007/978-1-4939-7128-2_10 Kelley DE He J Menshikova EV Ritov VB 2002

Article Type:
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DOI:
https://doi.org/10.1530/JOE-17-0557
Volume/Issue:
Volume 238: Issue 2
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Ghania Ramdani Department of Medicine, University of California, San Diego, La Jolla, California, USA

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Nadine Schall Department of Medicine, University of California, San Diego, La Jolla, California, USA
The Institute for Pharmacology and Toxicology, University of Bonn, Bonn, Germany

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Hema Kalyanaraman Department of Medicine, University of California, San Diego, La Jolla, California, USA

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Nisreen Wahwah Department of Medicine, University of California, San Diego, La Jolla, California, USA

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Sahar Moheize Department of Medicine, University of California, San Diego, La Jolla, California, USA

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Jenna J Lee Department of Bioengineering, University of California, San Diego, La Jolla, California, USA

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Robert L Sah Department of Bioengineering, University of California, San Diego, La Jolla, California, USA

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Alexander Pfeifer The Institute for Pharmacology and Toxicology, University of Bonn, Bonn, Germany

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Darren E Casteel Department of Medicine, University of California, San Diego, La Jolla, California, USA

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Renate B Pilz Department of Medicine, University of California, San Diego, La Jolla, California, USA

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-CA023100 (UCSD Gene Targeting Mouse Core), P30-NS047101 (UCSD Neuroscience Microscopy Shared Facility) and P30-AR04603 (University of Alabama, Birmingham, Center for Metabolic Bone Disease). N S was supported by the Deutsche Forschungsgemeinschaft

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DOI:
https://doi.org/10.1530/JOE-18-0286
Volume/Issue:
Volume 238: Issue 3
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Colin P Sibley Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
St Mary’s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

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Swanson A Kloczko E Boyd M Barker H Avdic-Belltheus A Martin J Zachary I Peebles D 2016 Gene targeting to the uteroplacental circulation of pregnant guinea pigs . Reproductive Sciences 23 1087 – 1095 . ( doi:10

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0185
Volume/Issue:
Volume 234: Issue 2
Open access
Pengli Bu Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Shintaro Yagi Laboratory of Cellular Biochemistry, Veterinary Medical Sciences/Animal Resource Sciences, The University of Tokyo, Tokyo, Japan

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Kunio Shiota Laboratory of Cellular Biochemistry, Veterinary Medical Sciences/Animal Resource Sciences, The University of Tokyo, Tokyo, Japan
Waseda Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

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S M Khorshed Alam Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Jay L Vivian Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Michael W Wolfe Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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M A Karim Rumi Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Damayanti Chakraborty Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Kaiyu Kubota Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Pramod Dhakal Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

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Michael J Soares Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA

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.komp.org ; VG10539). The University of Kansas Medical Center Transgenic and Gene-targeting Facility (Kansas City, KS, USA) injected the mutant ES cells into C57BL/6 blastocysts. Germline-competent chimeras were generated on C57BL/6 background, and the mutation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0250
Volume/Issue:
Volume 234: Issue 2
Free access
Marian Joëls Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands
University of Groningen, University Medical Center, Groningen, The Netherlands

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E Ronald de Kloet Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

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14 675 – 689 . ( doi:10.1046/j.0953-816x.2001.01685.x ) Datson NA Morsink MC Meijer OC de Kloet ER 2008 Central corticosteroid actions: Search for gene targets . European Journal of Pharmacology 583 272 – 289 . ( doi:10

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0660
Volume/Issue:
Volume 234: Issue 1
Free access
Vikki L Poole School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK

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Christopher J McCabe School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK

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vitro , but concerns over the systemic effects associated with retinoid use need to be carefully considered. While exogenous expression of NIS in cells has proved successful in vivo , delivery methods for gene targeting are not fully optimised and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0234
Volume/Issue:
Volume 227: Issue 1
Free access