( Bjorbaek & Kahn 2004 ). Leptin also inhibits AMP-activated protein kinase (AMPK) activity in the arcuate nucleus and in the paraventricular nucleus of the hypothalamus ( Minokoshi et al . 2004 ). Glucagon-like peptide-1 (GLP1), a gastrointestinal hormone
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Sayaka Akieda-Asai, Paul-Emile Poleni, Kazuya Hasegawa and Yukari Date
Shin-ya Ueda, Takahiro Yoshikawa, Yoshihiro Katsura, Tatsuya Usui, Hayato Nakao and Shigeo Fujimoto
endocrine organs, including ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), and oxyntomodulin ( Huda et al . 2006 , Näslund & Hellstrom 2007 , Wren & Bloom 2007 ). While of these, ghrelin is
Paige V Bauer and Frank A Duca
. 2015 , Buse et al . 2016 ). Interestingly, this is not the only evidence for a therapeutic role of the gut in diabetes treatment. Over the past decade, incretin-based therapies including glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl
Lars P Klieverik, Ewout Foppen, Mariëtte T Ackermans, Mireille J Serlie, Hans P Sauerwein, Thomas S Scanlan, David K Grandy, Eric Fliers and Andries Kalsbeek
.c.v. bolus infusion, isotope dilution and blood sampling were conducted to permit measurement of endogenous glucose production (EGP), and the concentration of plasma glucose, insulin, glucagon, corticosterone, thyroid stimulating hormone (TSH), T 3 and T 4
Joshua A Kulas, Kendra L Puig and Colin K Combs
chemiluminescent visualization. Antibodies Antibodies against full-length APP (ab32136), BACE2 (ab8025), glucagon (ab10988), IDE (ab32216) and the insulin receptor (ab69508) were purchased from Abcam. Antibodies against insulin (L6B10), p-GSK3β (D3A4), GSK3
Sandra Fontanière, Bertrand Duvillié, Raphaël Scharfmann, Christine Carreira, Zhao-Qi Wang and Chang-Xian Zhang
experiments were guinea pig anti-insulin (1:500, Dako, Capintaria, CA, USA), rabbit anti-glucagon (1:600, NovoCastra, Milton Keynes, UK), anti-mucin-1 (1:200, Neomarkers, Fremont, CA, USA) and goat anti-menin (C19, 1:500). For cultured pancreatic rudiments, 4
Li Ding, Yue Yin, Lingling Han, Yin Li, Jing Zhao and Weizhen Zhang
Introduction Pancreatic islet contains four major types of endocrine cells, including α, β, δ and PP cells, which secret glucagon, insulin, somatostatin and pancreatic polypeptide, respectively. All types of pancreatic endocrine cells arise
Birgitte N Friedrichsen, Nicole Neubauer, Ying C Lee, Vivian K Gram, Niels Blume, Jacob S Petersen, Jens H Nielsen and Annette Møldrup
Introduction The intestinal incretin hormones, glucagon-like peptide-1 (7–36) amide (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are released in response to fat and carbohydrate ingestion. Both peptides act to augment
Neil Tanday, Peter R Flatt, Nigel Irwin and R Charlotte Moffett
incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), in T2DM have been linked to direct positive effects at the level of the endocrine pancreas. This includes, but not limited to, potentiation of glucose
Mohamed Lotfy, Jaipaul Singh, Hameed Rashed, Saeed Tariq, Erika Zilahi and Ernest Adeghate
endocrine and an exocrine system with much interaction between the two parts ( Shetzline & Liddle 2002 ). The GI tract secretes a number of hormones including glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP1; Drucker 2003 b
