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Gabriel Forn-Cuní Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Monica Varela Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Conrado M Fernández-Rodríguez Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Antonio Figueras Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Beatriz Novoa Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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, enrichment analysis predicted that the circadian rhythm was the only statistically enriched KEGG pathway in the pathological liver from obese individuals compared with controls (corrected P value=0.00076). Belonging to this pathway, Period family genes

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Juliane K Czeczor Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Amanda J Genders Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Kathryn Aston-Mourney Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Timothy Connor Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Liam G Hall Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Kyoko Hasebe Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Megan Ellis Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Kirstie A De Jong Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Darren C Henstridge Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Peter J Meikle Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Mark A Febbraio Division of Diabetes and Metabolism, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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Ken Walder Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

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Sean L McGee Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia
Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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diurnal effects may influence APP processing in the context of the aforementioned models is unknown. Symptoms in humans suffering from AD include the disruption of their sleep cycle and day time activity. While studies on the circadian rhythm on mice in

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Keiko Nakahara
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Tetsuro Katayama Department of Veterinary Physiology, Genetic Resource Division, Interdisciplinary Research Organization, Department of Biochemistry, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan

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Keisuke Maruyama
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Takanori Ida Department of Veterinary Physiology, Genetic Resource Division, Interdisciplinary Research Organization, Department of Biochemistry, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan

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Kenji Mori Department of Veterinary Physiology, Genetic Resource Division, Interdisciplinary Research Organization, Department of Biochemistry, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan

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Mikiya Miyazato Department of Veterinary Physiology, Genetic Resource Division, Interdisciplinary Research Organization, Department of Biochemistry, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan

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Kenji Kangawa Department of Veterinary Physiology, Genetic Resource Division, Interdisciplinary Research Organization, Department of Biochemistry, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan

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Noboru Murakami
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was evaluated by real-time PCR, basal levels were significantly higher at 12 h (0700 h) than at 2 h (2100 h) after saline treatment, suggesting a circadian rhythm of NMS mRNA levels ( Mori et al . 2005 ). On the other hand, there was no significant

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Jie Xu INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Amaury Jean-Marie Bekaert INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Joëlle Dupont INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Sarah Rouve INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Isabella Annesi-Maesano INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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C Daniel De Magalhaes Filho INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Laurent Kappeler INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Martin Holzenberger INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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effects of stress and circadian rhythm on circulating GH. We also used rank plot analysis to investigate the GH pattern in bIGF1RKO +/− mice ( Kappeler et al . 2008 ) and found this long-lived mutant had extended trough periods and rarefied peaks

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Gabriele E Mattos
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Jan-Michael Heinzmann
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Stefanie Norkowski
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Jean-Christophe Helbling Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Amandine M Minni Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Marie-Pierre Moisan Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Chadi Touma
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different litters per line. Animals were between 3 and 5 months of age during the experiments. All experiments were performed during the trough of the circadian rhythm of GC secretion (between 0900 and 1200 h, Touma et al . (2009) ) and the order of

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Daniel Simões Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Patrícia Riva Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Rodrigo Antonio Peliciari-Garcia Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil
Department of Biological Sciences, Laboratory of Biosystems, Federal University of São Paulo, Diadema, São Paulo, Brazil

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Vinicius Fernandes Cruzat Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Maria Fernanda Graciano Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Ana Claudia Munhoz Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Marco Taneda Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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José Cipolla-Neto Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Angelo Rafael Carpinelli Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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pancreatic islets . American Journal of Physiology 276 C507 – C510 . Peschke E Peschke D 1998 Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets . Diabetologia 41 1085 – 1092 . ( doi:10.1007/s

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D A Zieba
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M Szczesna
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B Klocek-Gorka
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E Molik
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T Misztal Department of Sheep and Goat Breeding, Department of Endocrinology, Animal Reproduction Laboratory, Independent Laboratory of Molecular Biology and Research, Department of Animal Science, University of Agriculture, 30-059 Krakow, Poland

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G L Williams Department of Sheep and Goat Breeding, Department of Endocrinology, Animal Reproduction Laboratory, Independent Laboratory of Molecular Biology and Research, Department of Animal Science, University of Agriculture, 30-059 Krakow, Poland

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K Romanowicz Department of Sheep and Goat Breeding, Department of Endocrinology, Animal Reproduction Laboratory, Independent Laboratory of Molecular Biology and Research, Department of Animal Science, University of Agriculture, 30-059 Krakow, Poland

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E Stepien Department of Sheep and Goat Breeding, Department of Endocrinology, Animal Reproduction Laboratory, Independent Laboratory of Molecular Biology and Research, Department of Animal Science, University of Agriculture, 30-059 Krakow, Poland

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D H Keisler Department of Sheep and Goat Breeding, Department of Endocrinology, Animal Reproduction Laboratory, Independent Laboratory of Molecular Biology and Research, Department of Animal Science, University of Agriculture, 30-059 Krakow, Poland

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M Murawski
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clearly warranted in order to determine the modulatory effects of both the estrogens and progesterone. A circadian relationship between melatonin and leptin concentrations was reported earlier by Gündüz (2002) who suggested that photoperiod

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Michelle Keramidas Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Caroline Faudot Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Agnès Cibiel Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Jean-Jacques Feige Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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Michaël Thomas Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France
Institut National de la Santé et de la Recherche Médicale, Commissariat à l'Energie Atomique, Université Joseph Fourier, Unité 878, Grenoble, France

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where it affects circadian rhythm, and in the seminiferous tubules of the testis ( Wechselberger et al . 1999 , Melchiorri et al . 2001 , Cheng et al . 2002 , LeCouter et al . 2003 a , b ). Moreover, the distinct patterns of expression of both

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Hanna E Auvinen Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Johannes A Romijn Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Nienke R Biermasz Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Hanno Pijl Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Louis M Havekes Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Johannes W A Smit Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Patrick C N Rensen Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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Alberto M Pereira Department of Endocrinology and Metabolic Diseases, TNO-Metabolic Health Research, Leiden University Medical Center, Room C5-R61, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands

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corticosterone levels both acutely and in the long term A diurnal corticosterone rhythm was observed in all animals, with a nadir in the morning (0700 h) and with peak values during the last light hour before the dark phase (1800 h). The HFD decreased plasma

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Nathalie Marissal-Arvy INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Rachel Hamiani INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Emmanuel Richard INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Marie-Pierre Moisan INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Véronique Pallet INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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/C rats. We first measured plasma corticosterone in basal inactive and active phases of the circadian rhythm. In both cases, the vitamin A deficiency induced an increase in HPA axis activity, which was restored to control level by the supplementation

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