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Sergio Di Meo Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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Susanna Iossa Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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Paola Venditti Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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, consequence of the obesity is the increased risk for various illnesses, such as diabetes mellitus, gallbladder disease, osteoarthritis, coronary artery disease and some forms of cancer ( Vona-Davis et al . 2007 ). In the last century, the disease that is

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Philip Newsholme School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Vinicius Cruzat School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Frank Arfuso School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Kevin Keane School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Introduction Homoeostatic regulation of fuel metabolism in the body is a tightly controlled process and dysregulation can lead to pathological conditions such as diabetes mellitus (DM), cardiovascular disease, stroke, renal disease and other

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Vinicius Fernandes Cruzat School of Biomedical Sciences, Directorate of Nutrition, Dietetics and Food Technology, School of Public Health, Curtin Health Innovation Research Institute of Ageing and Chronic Disease - Curtin University, GPO Box U1987, Perth, Western Australia, Australia 6845

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Kevin Noel Keane School of Biomedical Sciences, Directorate of Nutrition, Dietetics and Food Technology, School of Public Health, Curtin Health Innovation Research Institute of Ageing and Chronic Disease - Curtin University, GPO Box U1987, Perth, Western Australia, Australia 6845

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Anita Lavarda Scheinpflug School of Biomedical Sciences, Directorate of Nutrition, Dietetics and Food Technology, School of Public Health, Curtin Health Innovation Research Institute of Ageing and Chronic Disease - Curtin University, GPO Box U1987, Perth, Western Australia, Australia 6845

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Robson Cordeiro School of Biomedical Sciences, Directorate of Nutrition, Dietetics and Food Technology, School of Public Health, Curtin Health Innovation Research Institute of Ageing and Chronic Disease - Curtin University, GPO Box U1987, Perth, Western Australia, Australia 6845

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Mario J Soares School of Biomedical Sciences, Directorate of Nutrition, Dietetics and Food Technology, School of Public Health, Curtin Health Innovation Research Institute of Ageing and Chronic Disease - Curtin University, GPO Box U1987, Perth, Western Australia, Australia 6845

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Philip Newsholme School of Biomedical Sciences, Directorate of Nutrition, Dietetics and Food Technology, School of Public Health, Curtin Health Innovation Research Institute of Ageing and Chronic Disease - Curtin University, GPO Box U1987, Perth, Western Australia, Australia 6845

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Introduction The prevalence of diabetes, especially type 2 diabetes mellitus (T2DM), is continuing to rise at rapid rates ( Whiting et al . 2011 ). In turn, obesity and metabolic syndrome are significant risk predictors for T2DM ( Pradhan 2007

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Charlotte Lawson Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Jose M Vicencio Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Derek M Yellon Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Sean M Davidson Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Introduction It is well established that patients with metabolic diseases, in particular insulin resistance and type 2 diabetes mellitus (T2DM), are more than twice as likely to develop accelerated cardiovascular disease (CVD) including

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Srividya Vasu SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Mary K McGahon Centre for Experimental Medicine, Queens University of Belfast, Belfast, UK

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R Charlotte Moffett SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Tim M Curtis Centre for Experimental Medicine, Queens University of Belfast, Belfast, UK

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J Michael Conlon SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Yasser H A Abdel-Wahab SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Peter R Flatt SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, UK

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Introduction Incidence of type 2 diabetes is constantly on the rise, owing to an increase in consumption of a Western diet, sedentary lifestyle, obesity and ageing population ( Stumvoll et al. 2008 , McCarthy 2011 ). Current therapies

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Anna Cinkajzlová Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic

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Miloš Mráz Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Martin Haluzík Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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2010 ). Excessive accumulation of VAT phenotypically presented as android obesity is associated with higher metabolic risk and the development of insulin resistance, arterial hypertension, type 2 diabetes mellitus (T2DM) and cardiovascular diseases

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Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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reversible with weight loss ( Grossmann 2018 ) and does not demonstrate androgen deficiency. Although weight loss will both increase serum testosterone and prevent type 2 diabetes (T2D), it is unclear whether this effect is mediated directly by the increase

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G Üçkaya
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P Delagrange
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A Chavanieu
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G Grassy
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M-F Berthault
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A Ktorza
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E Cerasi
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G Leibowitz
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N Kaiser
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Introduction Type 2 diabetes results from failure to increase insulin secretion in the face of insulin resistance ( Cerasi 1995 , Kahn 2003 ). Studies in humans and animal models of type 2 diabetes show marked β-cell dysfunction

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Sojin Lee Division of Endocrinology and Diabetes, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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H Henry Dong Division of Endocrinology and Diabetes, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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mutations in FoxO genes or altered expression of FoxO proteins are associated with diseases including diabetes and cancer or with reduced lifespan in mammals. This latter aspect is exemplified by the illustration of role of the FoxO ortholog Daf16 in

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Sergio Di Meo Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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Susanna Iossa Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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Paola Venditti Department of Biology, University of Naples ‘Federico II’, Naples, Italy

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Introduction In recent years, the observation that insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are growing dramatically all over the world has stimulated the research on such metabolic disorders and their possible therapy. At

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