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Eduardo Esteban-Zubero Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain

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Francisco Agustín García-Gil Department of Surgery, Gynaecology and Obstetrics, University of Zaragoza, Zaragoza, Spain

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Laura López-Pingarrón Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain

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Moisés Alejandro Alatorre-Jiménez Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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Pablo Iñigo-Gil Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain

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Dun-Xian Tan Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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José Joaquín García Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain

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Russel J Reiter Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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, Kilic et al. 2005 , Wang et al. 2005 ). This is important because eNOS-derived NO· is suggested to be an important protective factor against vascular endothelium pathophysiology because it is produced early and may abrogate the microcirculatory

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0117
Volume/Issue:
Volume 229: Issue 3
Free access
Pasquale Florio Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Giulia De Falco Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Eleonora Leucci Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Michela Torricelli Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Paulo B Torres Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Paolo Toti Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Arianna Dell’Anna Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Ennio Tiso Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Rosa Santopietro Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Lorenzo Leoncini Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Felice Petraglia Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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human endometrial cancer. Oncology Reports 15 375 –379. Huang Y , Chan FL, Lau CW, Tsang SY, He GW, Chen ZY & Yao X 2002 Urocortin-induced endothelium-dependent relaxation of rat coronary artery: role of nitric oxide

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06726
Volume/Issue:
Volume 190: Issue 1
Free access
Waljit S Dhillo Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Kevin G Murphy Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Steve Bloom Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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metabolically inert, such as adipose tissue, the vascular endothelium or the skin, are now considered active endocrine organs. For example, adipose tissue secretes a number of signalling proteins called adipokines. Over 50 adipokines have been described to date

Article Type:
Article Commentary
DOI:
https://doi.org/10.1677/joe.1.06861
Volume/Issue:
Volume 190: Issue 1
Free access
Prabhakara R Nagareddy Department of Nutrition Sciences, University of Alabama, Birmingham, UK

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Sunil K Noothi Department of Nutrition Sciences, University of Alabama, Birmingham, UK

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Michelle C Flynn Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia
Department of Immunology, Monash University, Melbourne, Australia

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Andrew J Murphy Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia
Department of Immunology, Monash University, Melbourne, Australia

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endothelium ( von Hundelshausen et al . 2001 ). It should be noted that antiplatelet therapy can reduce CVD risk in non-diabetic subjects ( Antiplatelet Trialists’ Collaboration 1994 ); however, such therapies are less effective in the context of diabetes

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0082
Volume/Issue:
Volume 238: Issue 1
Free access
Jennifer A Crookshank Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Daniel Serrano Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Gen-Sheng Wang Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Christopher Patrick Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

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Baylie S Morgan Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biomedical Sciences, University of Ottawa, Ottawa, Ontario, Canada

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Marie-France Paré Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Fraser W Scott Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada

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, red line) (49.3 vs 54.6% incidence). (B) Increased endothelium-associated-CD68 + cells were observed in prediabetic rats (red circles) compared to nondiabetic rats (open circles) ( n  = 6/group). Gene expression in prediabetic and nondiabetic pancreas

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0328
Volume/Issue:
Volume 239: Issue 2
Free access
Toshihiro Sakurai Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan

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Kenta Suzuki Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan

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Mikihiro Yoshie Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan

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Keisuke Hashimoto Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan

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Eiichi Tachikawa Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan

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Kazuhiro Tamura Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan

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-Vitiani et al . 2010 ). The EC preparation in this study might include a subset of granulosa stem-like cells that show characteristics of endothelial progenitors capable of maturation into ECs under endothelium condition. This study is, to the best of our

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0357
Volume/Issue:
Volume 209: Issue 1
Free access
Mauricio S Krause Biomedical Research Group, UCD School of Biomolecular and Biomedical Sciences, School of Biomedical Sciences, School of Physical Education, Department of Science, Institute of Technology Tallaght, Dublin, Ireland
Biomedical Research Group, UCD School of Biomolecular and Biomedical Sciences, School of Biomedical Sciences, School of Physical Education, Department of Science, Institute of Technology Tallaght, Dublin, Ireland

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Neville H McClenaghan Biomedical Research Group, UCD School of Biomolecular and Biomedical Sciences, School of Biomedical Sciences, School of Physical Education, Department of Science, Institute of Technology Tallaght, Dublin, Ireland

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Peter R Flatt Biomedical Research Group, UCD School of Biomolecular and Biomedical Sciences, School of Biomedical Sciences, School of Physical Education, Department of Science, Institute of Technology Tallaght, Dublin, Ireland

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Paulo I Homem de Bittencourt Biomedical Research Group, UCD School of Biomolecular and Biomedical Sciences, School of Biomedical Sciences, School of Physical Education, Department of Science, Institute of Technology Tallaght, Dublin, Ireland

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Colin Murphy Biomedical Research Group, UCD School of Biomolecular and Biomedical Sciences, School of Biomedical Sciences, School of Physical Education, Department of Science, Institute of Technology Tallaght, Dublin, Ireland

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Philip Newsholme Biomedical Research Group, UCD School of Biomolecular and Biomedical Sciences, School of Biomedical Sciences, School of Physical Education, Department of Science, Institute of Technology Tallaght, Dublin, Ireland

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have been reported in patients with type 2 diabetes ( Pieper & Dondlinger 1997 ). l -Arginine also increased β-cell neogenesis and antioxidant defenses in rats treated with alloxan and aided recovery of endothelium-dependent relaxation in patients with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0236
Volume/Issue:
Volume 211: Issue 1
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Christian Hölscher Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK

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apoptosis-related signalling. Furthermore, exendin-4 can reduce monocyte adhesion to aortic endothelium in an inflammatory response in atherosclerosis and also prevents LPS-induced cytokine and chemokine release in both human and mouse monocytes ( Arakawa

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0221
Volume/Issue:
Volume 221: Issue 1
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M B Mazzucco Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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R Higa Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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E Capobianco Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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M Kurtz Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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A Jawerbaum Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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V White Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina

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human endothelium of umbilical veins and arteries ( Akerman et al . 2002 ). Other studies have shown that administration of leptin induces a threefold increase in leptinemia in both fetuses and adult animals ( de Oliveira et al . 2007 , Su et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0021
Volume/Issue:
Volume 217: Issue 3
Free access
Jung-Hoon Kang Internal Medicine, Department of Internal Medicine, Departments of

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Seo-Yoon Chang Internal Medicine, Department of Internal Medicine, Departments of

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Hyun-Jong Jang Internal Medicine, Department of Internal Medicine, Departments of

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Dong-Bin Kim Internal Medicine, Department of Internal Medicine, Departments of

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Gyeong Ryul Ryu Internal Medicine, Department of Internal Medicine, Departments of

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Seung Hyun Ko Internal Medicine, Department of Internal Medicine, Departments of

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In-Kyung Jeong Internal Medicine, Department of Internal Medicine, Departments of

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Yang-Hyeok Jo Internal Medicine, Department of Internal Medicine, Departments of

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Myung-Jun Kim Internal Medicine, Department of Internal Medicine, Departments of

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aortic smooth muscle ( Koide et al . 1993 ), brown adipose tissue ( Nisoli et al . 1997 ), and brain endothelium ( Durieu-Trautmann et al . 1993 ) while cAMP decreased iNOS expression in pancreatic cells ( Andersen et al . 1996 ) and rat hepatocytes

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0507
Volume/Issue:
Volume 202: Issue 1
Free access