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Lars P Klieverik, Ewout Foppen, Mariëtte T Ackermans, Mireille J Serlie, Hans P Sauerwein, Thomas S Scanlan, David K Grandy, Eric Fliers and Andries Kalsbeek

hypothalamus, regulates most of the processes affected by thyronamines (body temperature, cardiac function, and energy metabolism). Moreover, a principal role in regulating hepatic glucose metabolism has recently emerged for the hypothalamus ( Obici et al

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Mathis Grossmann

70 years of clinical experience. On the other hand, in functional androgen deficiency due to axis suppression because of age-related comorbidities, treatment may aim for a specific health outcome, such as improvement of glucose metabolism, and

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Olivier Dumortier, Gaia Fabris, Didier F Pisani, Virginie Casamento, Nadine Gautier, Charlotte Hinault, Patricia Lebrun, Christophe Duranton, Michel Tauc, Stéphane Dalle, Julie Kerr-Conte, François Pattou, Marc Prentki and Emmanuel Van Obberghen

(disallowed genes) ( Quintens et al . 2008 , Pullen & Rutter 2013 ). Indeed, beta cells have a dedicated metabolism comprising a tightly regulated chain of elements from glucose sensors to a specialized exocytosis machinery. Glucose metabolism in beta cells

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Li Li, Xiaohua Li, Wenjun Zhou and Joseph L Messina

phosphorylation of IR substrates (IRSs) and the activation of cytosolic proteins, including phosphatidylinositol 3-kinase (PI3K). Activated PI3K phosphorylates/activates its substrates involved in glucose metabolism, such as glycogen synthase kinase-3 and p70 S6

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Kanta Kon, Hiroshi Tsuneki, Hisakatsu Ito, Yoshinori Takemura, Kiyofumi Sato, Mitsuaki Yamazaki, Yoko Ishii, Masakiyo Sasahara, Assaf Rudich, Takahiro Maeda, Tsutomu Wada and Toshiyasu Sasaoka

and behavioral circadian misalignments in modern lifestyle, such as shift work and late eating, lead to dysregulation of glucose metabolism and increased risk of type 2 diabetes ( Cedernaes et al. 2015 , Qian et al. 2016 ). Intriguingly, one night

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K L Franko, A J Forhead and A L Fowden

, little is known about the effects of commonly used control procedures, such as maternal saline or vehicle injection, on glucose metabolism of their offspring. The current study, therefore, compared the effects of maternal injection with dex or saline with

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S Patterson, P R Flatt, L Brennan, P Newsholme and N H McClenaghan

.p.m.) and the supernatant was treated with Chelex-100 resin and then lyophilised. Assessment of glucose metabolism by NMR spectroscopy The lyophilised cell extracts were dissolved in 3 ml H 2 O and then centrifuged at 1500

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B Maiztegui, M I Borelli, M A Raschia, H Del Zotto and J J Gagliardino

. 2003 ). Evidence in the literature has shown that glucokinase (GK) activity plays a pivotal role upon islet glucose metabolism and insulin secretion. As opposed to other hexokinases (HK), GK kinetics shows a cooperative glucose dependence (Hill

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Yu Wu, Tingting Wu, Jun Wu, Lei Zhao, Qing Li, Zac Varghese, John F Moorhead, Stephen H Powis, Yaxi Chen and Xiong Z Ruan

aggravated insulin resistance and glucose metabolism disorders in HFD-fed C57BL/6J mice The fasting glucose levels were unchanged in HFD-fed mice compared with NCD-fed mice ( Fig. 2 A and C). After glucose challenge, blood glucose concentration of HFD group

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Mariana Rosolen Tavares, Simone Ferreira Lemes, Thais de Fante, Cristina Saenz de Miera, Isadora Carolina Betim Pavan, Rosangela Maria Neves Bezerra, Patricia Oliveira Prada, Marcio Alberto Torsoni, Carol Fuzeti Elias and Fernando Moreira Simabuco

modulate hepatic glucose metabolism As hypothalamic S6K1 may control glucose homeostasis ( Ono et al. 2008 , Smith et al. 2015 ), we sought peripheral changes resulting from the S6Ks modulation in the hypothalamus. Mice with overexpression of