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Banrida Wahlang Department of Medicine, School of Medicine, Division of Gastroenterology, Hepatology & Nutrition, University of Louisville, Louisville, Kentucky, USA
UofL Superfund Research Center, University of Louisville, Louisville, Kentucky, USA
The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, Kentucky, USA

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), and the role of estrogens has been credited for the enhanced arsenic metabolism and clearance in females ( Tseng 2009 ). Age is another factor that could define sex-specific toxicity with metal exposures as it impacts bone redistribution, particularly

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Lauren Brady Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington, USA

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Peter S Nelson Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington, USA
Division of Medical Oncology, University of Washington, Seattle, Washington, USA

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cell exhaustion and improving response to PD-1-directed immunotherapy ( Guan et al. 2022 ). PC frequently metastasizes to the bone, an immune-suppressive environment that is driven in part by myeloid-derived suppressor cells that overexpress chemokine

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Rachel K Meyer School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA

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Frank A Duca School of Animal and Comparative Biomedical Sciences, College of Agricultural and Life Sciences, University of Arizona, Tucson, Arizona, USA
BIO5 Institute, University of Arizona, Tucson, Arizona, USA

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) Sjögren K Engdahl C Henning P Lerner UH Tremaroli V Lagerquist MK Bäckhed F & Ohlsson C 2012 The gut microbiota regulates bone mass in mice . Journal of Bone and Mineral Research 27 1357 – 1367 . ( https://doi.org/10.1002/jbmr.1588

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