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Gabriele E Mattos
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Jan-Michael Heinzmann
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Stefanie Norkowski
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Jean-Christophe Helbling Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Amandine M Minni Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Marie-Pierre Moisan Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Chadi Touma
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, sex hormone-, and corticosteroid-binding globulin (CBG, also called transcortin). CBG is a monomeric glycoprotein synthesized and stored mainly by the liver ( Rothschild et al . 1972 , Weiser et al . 1979 , Kuhn et al . 1986 , Hammond et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0255
Volume/Issue:
Volume 219: Issue 3
Free access
Marian Joëls Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Variation in brain exposure to corticosteroid hormones Humans or rodents that are exposed to potentially threatening situations (i.e. stressors, subjectively experienced as ‘stress’) are able to trigger a hormonal response that promotes

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0226
Volume/Issue:
Volume 238: Issue 3
Free access
A Feraco Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy
INSERM, UMR_S 1138, Teams 1, Centre de Recherche des Cordeliers, UPMC Univ Paris 06, Université Paris Descartes, Paris, France

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A Armani Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy

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R Urbanet INSERM, UMR_S 1138, Teams 1, Centre de Recherche des Cordeliers, UPMC Univ Paris 06, Université Paris Descartes, Paris, France

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A Nguyen Dinh Cat INSERM, UMR_S 1138, Teams 1, Centre de Recherche des Cordeliers, UPMC Univ Paris 06, Université Paris Descartes, Paris, France

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V Marzolla Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy

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F Jaisser INSERM, UMR_S 1138, Teams 1, Centre de Recherche des Cordeliers, UPMC Univ Paris 06, Université Paris Descartes, Paris, France

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M Caprio Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy

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. ( https://doi.org/10.1073/pnas.0503878102 ) 10.1073/pnas.0503878102 Caprio M Feve B Claes A Viengchareun S Lombes M Zennaro MC 2007 Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis . FASEB Journal 21 2185

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0314
Volume/Issue:
Volume 239: Issue 2
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E J Agnew Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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A Garcia-Burgos Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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R V Richardson Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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H Manos Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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A J W Thomson Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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K Sooy Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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G Just Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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N Z M Homer Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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C M Moran Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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P J Brunton Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK

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G A Gray Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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K E Chapman Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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fetuses is likely due to alterations in loading, possibly through the well-known increase in fetal blood pressure following antenatal corticosteroid administration ( Derks et al. 1997 , Bennet et al. 1999 ). In the surviving dexamethasone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0666
Volume/Issue:
Volume 241: Issue 3
Open access
Muneki Ikeda Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan

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Yasushi Hojo Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan
Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan

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Yoshimasa Komatsuzaki Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan

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Masahiro Okamoto Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan
Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan

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Asami Kato Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan

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Taishi Takeda Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan

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Suguru Kawato Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan
Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan
Department of Biophysics and Life Sciences, Bioinformatics Project of Japan Science and Technology Agency, Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Urology, Graduate School of Arts and Sciences, University of Tokyo, 3‐8‐1 Komaba, Meguro‐ku, Tokyo 152-8902, Japan

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Thanasoulis LC McEwen BS 1997 The effects of type I and type II corticosteroid receptor agonists on exploratory behavior and spatial memory in the Y-maze . Brain Research 759 76 – 83 . ( doi:10.1016/S0006-8993(97)00236-9 ) Daly RJ 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0078
Volume/Issue:
Volume 226: Issue 2
Free access
Kevin H Tsai ANZAC Research Institute, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia

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Mark S Cooper ANZAC Research Institute, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia

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I Hussain B Naylor AJ Jones SW Hansen MS Gorvin CM , 2022 11beta-hydroxysteroid dehydrogenase type 1 within osteoclasts mediates the bone protective properties of therapeutic corticosteroids in chronic inflammation . International Journal

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0289
Volume/Issue:
Volume 258: Issue 3
Free access
Stefanie Ruhs Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

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Alexander Nolze Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

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Ralf Hübschmann Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

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Claudia Grossmann Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Germany

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time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes . Pharmacological Reviews 64 901 . ( doi:10.1124/pr.112.005892 ) Karmazyn M Sostaric JV Gan XT 2001 The myocardial Na + /H

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0659
Volume/Issue:
Volume 234: Issue 1
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Sonnet S Jonker Center for Developmental Health, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA

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Daniel Kamna Center for Developmental Health, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA

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Dan LoTurco Department of Pediatrics, Perinatal Research Center, Anschutz Medical Campus, University of Colorado, Aurora, Colorado, USA

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Jenai Kailey Department of Pediatrics, Perinatal Research Center, Anschutz Medical Campus, University of Colorado, Aurora, Colorado, USA

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Laura D Brown Department of Pediatrics, Perinatal Research Center, Anschutz Medical Campus, University of Colorado, Aurora, Colorado, USA

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Reini SA Dutta G Wood CE Keller-Wood M 2008 Cardiac corticosteroid receptors mediate the enlargement of the ovine fetal heart induced by chronic increases in maternal cortisol . Journal of Endocrinology 198 419 – 427 . ( https://doi.org/10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0382
Volume/Issue:
Volume 239: Issue 2
Free access
Marianna Minnetti Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Valeria Hasenmajer Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Riccardo Pofi Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Mary Anna Venneri Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Krystallenia I Alexandraki Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Andrea M Isidori Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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adrenal clock machinery, which normally buffers response to ACTH and stress, appears dysregulated in adrenal tumors, favoring a higher, arrhythmic corticosteroid output. How and when such alterations can be reversible is the outcome of an ongoing

Article Type:
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DOI:
https://doi.org/10.1530/JOE-20-0066
Volume/Issue:
Volume 246: Issue 2
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IM Adcock
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SJ Lane
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Corticosteroids are the most potent anti-inflammatory agents used to treat chronic inflammatory diseases such as bronchial asthma. However, there are a small number (<5%) of asthmatic patients who do not respond well, or at all, to corticosteroid therapy - the corticosteroid-resistant and corticosteroid-dependent patients. Although this phenomenon is relatively uncommon, it poses a difficult therapeutic problem because few alternative therapies are available and these patients account for >50% of the health care costs of asthma. If the mechanisms for corticosteroid insensitivity are understood they may, in turn, provide insight into the key mechanism of corticosteroid action and allow a rational way to treat these individuals whose disease tends to be severe. Corticosteroid insensitivity is not limited to asthma and is a feature of other inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. Thus, elucidation of the cause for the relative lack of corticosteroid response in this subgroup of asthmatic individuals may have important implications for other diseases.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1780347
Volume/Issue:
Volume 178: Issue 3
Free access