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Department of Medicine, Monash University, Clayton, Victoria, Australia
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et al. 2005 ). The MR is unique in having two physiological agonist ligands, aldosterone and cortisol (corticosterone in rodents). However, they are not equivalent in that each induces subtly different conformations in the LBD with functional
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Interactions Consequence Thyroid GH enhances T4 conversion to T3 T4 falls during GH therapy Adrenal GH stimulates the conversion of active cortisol to inactive cortisone Risk of hypoadrenalism Gonadal Oestrogens impair GH
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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to APTs and PC ( Onguru et al. 2004 ). EGFR is overexpressed in invasive PAs ( Leriche et al. 1996 ) and correlates with tumour recurrence and cortisol/ACTH levels in Cushing’s disease ( Liu et al. 2019 ). The PI3K/Akt/mTOR and Raf